Rapid transformation of protein-caged nanomaterials into microbubbles as bimodal imaging agents

Cheng An J Lin; Wen Kai Chuang; Zih Yun Huang; Shih Tsung Kang; Ching Yi Chang; Ching Ta Chen; Jhih Liang Li; Jimmy K. Li; Hsueh Hsiao Wang; Fu Chen Kung; Ji Lin Shen; Wen Hsiung Chan; Chih Kuang Yeh; Hung I. Yeh; Wen Fu T Lai; Walter H. Chang

doi:10.1021/nn300768d

Rapid transformation of protein-caged nanomaterials into microbubbles as bimodal imaging agents

Cheng An J Lin, Wen Kai Chuang, Zih Yun Huang, Shih Tsung Kang, Ching Yi Chang, Ching Ta Chen, Jhih Liang Li, Jimmy K. Li, Hsueh Hsiao Wang, Fu Chen Kung, Ji Lin Shen, Wen Hsiung Chan, Chih Kuang Yeh, Hung I. Yeh, Wen Fu T Lai, Walter H. Chang

Graduate Institute of Clinical Medicine

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Figure Persented: We present a general method for converting colloidal nanomaterials into microbubbles as ultrasound contrast agents. Protein-caged nanomaterials, made either by self-assembled nanoparticles' protein corona or by fluorescent gold nanoclusters, can be rapidly transformed into microbubbles via a sonochemical route, which promote disulfide cross-linking of cysteine residues between protein-caged nanomaterials and free albumin during acoustic cavitation. The proposed methods yielded microbubbles with multiple functions by adjusting the original nanoparticle/protein mixture. We also showed a new dual-modal imaging agent of fluorescent gold microbubbles in vitro and in vivo, which can hold many potential applications in medical diagnostics and therapy.

Original language	English
Pages (from-to)	5111-5121
Number of pages	11
Journal	ACS Nano
Volume	6
Issue number	6
DOIs	https://doi.org/10.1021/nn300768d
Publication status	Published - Jun 26 2012

Keywords

bimodal imaging
fluorescent gold nanoclusters
microbubbles
protein corona
quantum dots
ultrasound

ASJC Scopus subject areas

Engineering(all)
Materials Science(all)
Physics and Astronomy(all)

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Lin, C. A. J., Chuang, W. K., Huang, Z. Y., Kang, S. T., Chang, C. Y., Chen, C. T., Li, J. L., Li, J. K., Wang, H. H., Kung, F. C., Shen, J. L., Chan, W. H., Yeh, C. K., Yeh, H. I., Lai, W. F. T., & Chang, W. H. (2012). Rapid transformation of protein-caged nanomaterials into microbubbles as bimodal imaging agents. ACS Nano, 6(6), 5111-5121. https://doi.org/10.1021/nn300768d

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abstract = "Figure Persented: We present a general method for converting colloidal nanomaterials into microbubbles as ultrasound contrast agents. Protein-caged nanomaterials, made either by self-assembled nanoparticles' protein corona or by fluorescent gold nanoclusters, can be rapidly transformed into microbubbles via a sonochemical route, which promote disulfide cross-linking of cysteine residues between protein-caged nanomaterials and free albumin during acoustic cavitation. The proposed methods yielded microbubbles with multiple functions by adjusting the original nanoparticle/protein mixture. We also showed a new dual-modal imaging agent of fluorescent gold microbubbles in vitro and in vivo, which can hold many potential applications in medical diagnostics and therapy.",

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author = "Lin, {Cheng An J} and Chuang, {Wen Kai} and Huang, {Zih Yun} and Kang, {Shih Tsung} and Chang, {Ching Yi} and Chen, {Ching Ta} and Li, {Jhih Liang} and Li, {Jimmy K.} and Wang, {Hsueh Hsiao} and Kung, {Fu Chen} and Shen, {Ji Lin} and Chan, {Wen Hsiung} and Yeh, {Chih Kuang} and Yeh, {Hung I.} and Lai, {Wen Fu T} and Chang, {Walter H.}",

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doi = "10.1021/nn300768d",

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AU - Chuang, Wen Kai

AU - Huang, Zih Yun

AU - Kang, Shih Tsung

AU - Chang, Ching Yi

AU - Chen, Ching Ta

AU - Li, Jhih Liang

AU - Li, Jimmy K.

AU - Wang, Hsueh Hsiao

AU - Kung, Fu Chen

AU - Shen, Ji Lin

AU - Chan, Wen Hsiung

AU - Yeh, Chih Kuang

AU - Yeh, Hung I.

AU - Lai, Wen Fu T

AU - Chang, Walter H.

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N2 - Figure Persented: We present a general method for converting colloidal nanomaterials into microbubbles as ultrasound contrast agents. Protein-caged nanomaterials, made either by self-assembled nanoparticles' protein corona or by fluorescent gold nanoclusters, can be rapidly transformed into microbubbles via a sonochemical route, which promote disulfide cross-linking of cysteine residues between protein-caged nanomaterials and free albumin during acoustic cavitation. The proposed methods yielded microbubbles with multiple functions by adjusting the original nanoparticle/protein mixture. We also showed a new dual-modal imaging agent of fluorescent gold microbubbles in vitro and in vivo, which can hold many potential applications in medical diagnostics and therapy.

AB - Figure Persented: We present a general method for converting colloidal nanomaterials into microbubbles as ultrasound contrast agents. Protein-caged nanomaterials, made either by self-assembled nanoparticles' protein corona or by fluorescent gold nanoclusters, can be rapidly transformed into microbubbles via a sonochemical route, which promote disulfide cross-linking of cysteine residues between protein-caged nanomaterials and free albumin during acoustic cavitation. The proposed methods yielded microbubbles with multiple functions by adjusting the original nanoparticle/protein mixture. We also showed a new dual-modal imaging agent of fluorescent gold microbubbles in vitro and in vivo, which can hold many potential applications in medical diagnostics and therapy.

KW - bimodal imaging

KW - fluorescent gold nanoclusters

KW - microbubbles

KW - protein corona

KW - quantum dots

KW - ultrasound

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Rapid transformation of protein-caged nanomaterials into microbubbles as bimodal imaging agents

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Keywords

ASJC Scopus subject areas

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