Rapid transformation of protein-caged nanomaterials into microbubbles as bimodal imaging agents

Cheng An J Lin, Wen Kai Chuang, Zih Yun Huang, Shih Tsung Kang, Ching Yi Chang, Ching Ta Chen, Jhih Liang Li, Jimmy K. Li, Hsueh Hsiao Wang, Fu Chen Kung, Ji Lin Shen, Wen Hsiung Chan, Chih Kuang Yeh, Hung I. Yeh, Wen Fu T Lai, Walter H. Chang

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


Figure Persented: We present a general method for converting colloidal nanomaterials into microbubbles as ultrasound contrast agents. Protein-caged nanomaterials, made either by self-assembled nanoparticles' protein corona or by fluorescent gold nanoclusters, can be rapidly transformed into microbubbles via a sonochemical route, which promote disulfide cross-linking of cysteine residues between protein-caged nanomaterials and free albumin during acoustic cavitation. The proposed methods yielded microbubbles with multiple functions by adjusting the original nanoparticle/protein mixture. We also showed a new dual-modal imaging agent of fluorescent gold microbubbles in vitro and in vivo, which can hold many potential applications in medical diagnostics and therapy.

Original languageEnglish
Pages (from-to)5111-5121
Number of pages11
JournalACS Nano
Issue number6
Publication statusPublished - Jun 26 2012


  • bimodal imaging
  • fluorescent gold nanoclusters
  • microbubbles
  • protein corona
  • quantum dots
  • ultrasound

ASJC Scopus subject areas

  • General Engineering
  • General Materials Science
  • General Physics and Astronomy


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