Quercetin and ferulic acid aggravate renal carcinoma in long-term diabetic victims

Chiu Lan Hsieh, Chiung Chi Peng, Yu Ming Cheng, Li Yun Lin, Yaw Bee Ker, Chi Huang Chang, Kuan Chou Chen, Robert Y. Peng

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


Many phytoantioxidants have therapeutic drawbacks due to their potent prooxidant bioactivity. It is hypothesized that phytoantioxidants (PAO) are beneficial only to the early-stage diabetes mellitus (DM) and will become ineffective once renopathy occurs. Gallic acid, rutin, EGCG, ferulic acid (FA), and quercetin were tried on the streptozotocin (STZ)-induced DM rat model for a 28 week experimental period. All of these PAO were shown to be ineffective for hypoglycemic action. The incidence of cataract (50%), injured glomerules, and renal cell carcinoma (RCC) was very common, among which the most severely affected involved the quercetin- and the FA-treated groups. The tumorigenicity of ferulic acid is still unclear. However, for quercetin, this can be attributted to (i) the prooxidant effect, (ii) the insulin-secretagogue bioactivity, and (iii) the competitive and noncompetitive inhibition on the O-methyltransferase to enhance the estradiol-induced tumorigenesis. Conclusively, quercetin and FA are able to aggravate, if not induce, nephrocarcinoma. It is tie to reevaluate the tumorigenic detrimental effect of PAO, especially those exhibiting prooxidant bioactivity.

Original languageEnglish
Pages (from-to)9273-9280
Number of pages8
JournalJournal of Agricultural and Food Chemistry
Issue number16
Publication statusPublished - Aug 25 2010
Externally publishedYes


  • Diabetes mellitus
  • Quercetin
  • Renal carcimoma
  • Streptozotocin

ASJC Scopus subject areas

  • General Agricultural and Biological Sciences
  • General Chemistry


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