TY - JOUR
T1 - Quantitative pathology of cutaneous nerve terminal degeneration in the human skin
AU - Chien, Hsiung-Fei
AU - Tseng, T.-J.
AU - Lin, W.-M.
AU - Yang, C.-C.
AU - Chang, Y.-C.
AU - Chen, R.-C.
AU - Hsieh, S.-T.
N1 - 被引用次數:63
Export Date: 16 March 2016
CODEN: ANPTA
通訊地址: Hsieh, S.-T.; Department of Anatomy/Cell Biology, Natl. Taiwan Univ. College Medicine, 1 Jen-Ai Road, Taipei 10018, Taiwan; 電子郵件: [email protected]
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(1999) Neurology, 53, pp. 1614-1615; Kennedy, W.R., Wendelschafer-Crabb, G., The innervation of human epidermis (1993) J Neurol Sci, 115, pp. 184-190; Kennedy, W.R., Wendelschafer-Crabb, G., Johnson, T., Quantitation of epidermal nerves in diabetic neuropathy (1996) Neurology, 47, pp. 1042-1048; Kennedy, W.R., Nolano, M., Wendelschafer-Crabb, G., Johnson, T.L., Tamura, E., A skin blister method to study epidermal nerves in peripheral nerve disease (1999) Muscle Nerve, 22, pp. 360-371; Lauria, G., Holland, N., Hauer, P., Cornblath, D.R., Griffin, J.W., McArthur, J.C., Epidermal innervation: Changes with aging, topographic location, and in sensory neuropathy (1999) J Neurol Sci, 164, pp. 172-178; Liang, Y., Johansson, O., Light and electron microscopic demonstration of the p75 nerve growth factor receptor in normal human cutaneous nerve fibers: New vistas (1998) J Invest Dermatol, 111, pp. 114-118; Lin, Y.H., Huang, M.H., Chang, Y.C., Tai, T.Y., Chen, W.H., Yang, C.C., Chen, R.C., Hsieh, S.T., Quantitative sensory testing: Normative values and its application in diabetic neuropathy (1998) Acta Neurol Taiwan, 7, pp. 176-184; McArthur, J.C., Stocks, E.A., Hauer, P., Cornblath, D.R., Griffin, J.W., Epidermal nerve fiber density: Normative reference range and diagnostic efficiency (1998) Arch Neurol, 55, pp. 1513-1520; McCarthy, B., Hsieh, S.T., Stocks, E.A., Hauer, P., Macko, C., Cornblath, D.R., Griffin, J.W., McArthur, J.C., Cutaneous innervation in sensory neuropathies: Evaulation by skin biopsy (1995) Neurology, 45, pp. 1848-1855; Pan, C.L., Lin, Y.H., Lin, W.M., Tai, T.Y., Hsieh, S.T., Degeneration of nociceptive nerve terminals in human peripheral neuropathy (2001) Neuro Report, 12, pp. 1-6; Periquet, M.I., Novak, V., Collins, M.P., Nagaraja, H.N., Erdem, S., Nash, S.M., Freimer, M.L., Mendell, J.R., Painful sensory neuropathy: Prospective evaluation using skin biopsy (1999) Neurology, 53, pp. 1641-1647; Scott, L.J., Griffin, J.W., Luciano, C., Barton, N.W., Banerjee, T., Crawford, T., McArthur, J.C., Schiffmann, R., Quantitative analysis of epidermal innervation in Fabry disease (1999) Neurology, 52, pp. 1249-1254; Stocks, E.A., McArthur, J.C., Griffin, J.W., Mouton, P.R., Griffin, J.W., An unbiased method for estimation of total epidermal nerve fiber length (1996) J Neurocytol, 25, pp. 637-644; Verze, L., Viglietti-Panzica, C., Plumari, L., Calcagni, M., Stella, M., Schrama, L.H., Panzica, G.C., Cutaneous innervation in hereditary sensory and autonomic neuropathy type IV (2000) Neurology, 55, pp. 126-128; Wang, L., Hilliges, M., Jernberg, T., Wiegleb-Edstronom, D., Johansson, O., Protein gene product 9.5-immunoreactive nerve fibers and cells in human skin (1990) Cell Tissue Res, 261, pp. 25-33; Wilkinson, K.D., Lee, K., Deshpande, S., Duerksen-Hughes, P., Boss, J.M., Pohl, J., The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase (1989) Science, 246, pp. 670-673
PY - 2001
Y1 - 2001
N2 - Pathological diagnosis of neuropathy has traditionally depended on ultrastructural examinations of nerve biopsy specimens, particularly for sensory neuropathies affecting unmyelinated and small-myelinated nociceptive nerves. These sensory nerves terminate in the epidermis of the skin, and the pathology of neuropathy usually begins from nerve terminals. We investigated the feasibility of diagnosing small-fiber sensory neuropathy by evaluating cutaneous innervation. Skin biopsy specimens of 3-mm in diameter were obtained from the distal leg and the distal forearm of 55 healthy controls and 35 patients with sensory neuropathy. In the healthy controls, conventional intraepidermal nerve fiber densities (IENF densities) as measured using the image analysis system in the distal forearm and in the distal leg were correlated (r=0.55, P
AB - Pathological diagnosis of neuropathy has traditionally depended on ultrastructural examinations of nerve biopsy specimens, particularly for sensory neuropathies affecting unmyelinated and small-myelinated nociceptive nerves. These sensory nerves terminate in the epidermis of the skin, and the pathology of neuropathy usually begins from nerve terminals. We investigated the feasibility of diagnosing small-fiber sensory neuropathy by evaluating cutaneous innervation. Skin biopsy specimens of 3-mm in diameter were obtained from the distal leg and the distal forearm of 55 healthy controls and 35 patients with sensory neuropathy. In the healthy controls, conventional intraepidermal nerve fiber densities (IENF densities) as measured using the image analysis system in the distal forearm and in the distal leg were correlated (r=0.55, P
KW - Epidermal nerve fibers
KW - Nerve degeneration
KW - Neuropathy
KW - Skin biopsy
KW - Skin innervation
KW - adult
KW - aged
KW - article
KW - clinical article
KW - controlled study
KW - correlation function
KW - density
KW - epidermis
KW - evaluation
KW - eye
KW - feasibility study
KW - female
KW - forearm
KW - histopathology
KW - human
KW - human tissue
KW - image analysis
KW - leg
KW - male
KW - measurement
KW - myelinated nerve
KW - nerve biopsy
KW - nerve degeneration
KW - nerve ending
KW - nerve fiber
KW - neuropathy
KW - nociceptive receptor
KW - nonmyelinated nerve
KW - prediction
KW - priority journal
KW - quantitative assay
KW - sensory neuropathy
KW - skin biopsy
KW - skin nerve
KW - tissue section
KW - ultrastructure
KW - Adult
KW - Aged
KW - Biopsy
KW - Cell Count
KW - Epidermis
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Nerve Degeneration
KW - Peripheral Nervous System Diseases
KW - Receptors, Sensory
M3 - Article
SN - 0001-6322
VL - 102
SP - 455
EP - 461
JO - Acta Neuropathologica
JF - Acta Neuropathologica
IS - 5
ER -