Quantitative determination of hydrazines derived from isoniazid in patients. I

Atsuko Noda; Tsuyoshi Goromaru; Kuang yang Hsu; Sadao Iguchi

doi:10.1248/bpb1978.1.132

Quantitative determination of hydrazines derived from isoniazid in patients. I

Atsuko Noda, Tsuyoshi Goromaru, Kuang yang Hsu, Sadao Iguchi

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Hydrazine formation took place in man after the oral administration of isoniazid. The successive excretion of free hydrazine, one of the well-known mutagens, was observed in the urine of the patients on INH-treatment. The intact INH and the other metabolites, acetyl-INH, acetyl-hydrazine and diacetylhydrazine, were also analyzed by gas chromatography-mass spectrometry.

Original language	English
Pages (from-to)	132-141
Number of pages	10
Journal	Journal of Pharmacobio-Dynamics
Volume	1
Issue number	2
DOIs	https://doi.org/10.1248/bpb1978.1.132
Publication status	Published - 1978
Externally published	Yes

Keywords

GC and GC-MS
patient on INH-treatment
quantitative analysis
successive excretion of free hydrazine
the metabolites in urine

ASJC Scopus subject areas

Pharmacology

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10.1248/bpb1978.1.132

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abstract = "Hydrazine formation took place in man after the oral administration of isoniazid. The successive excretion of free hydrazine, one of the well-known mutagens, was observed in the urine of the patients on INH-treatment. The intact INH and the other metabolites, acetyl-INH, acetyl-hydrazine and diacetylhydrazine, were also analyzed by gas chromatography-mass spectrometry.",

keywords = "GC and GC-MS, patient on INH-treatment, quantitative analysis, successive excretion of free hydrazine, the metabolites in urine",

author = "Atsuko Noda and Tsuyoshi Goromaru and Hsu, {Kuang yang} and Sadao Iguchi",

year = "1978",

doi = "10.1248/bpb1978.1.132",

language = "English",

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journal = "Journal of Pharmacobio-Dynamics",

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AU - Noda, Atsuko

AU - Goromaru, Tsuyoshi

AU - Hsu, Kuang yang

AU - Iguchi, Sadao

PY - 1978

Y1 - 1978

N2 - Hydrazine formation took place in man after the oral administration of isoniazid. The successive excretion of free hydrazine, one of the well-known mutagens, was observed in the urine of the patients on INH-treatment. The intact INH and the other metabolites, acetyl-INH, acetyl-hydrazine and diacetylhydrazine, were also analyzed by gas chromatography-mass spectrometry.

AB - Hydrazine formation took place in man after the oral administration of isoniazid. The successive excretion of free hydrazine, one of the well-known mutagens, was observed in the urine of the patients on INH-treatment. The intact INH and the other metabolites, acetyl-INH, acetyl-hydrazine and diacetylhydrazine, were also analyzed by gas chromatography-mass spectrometry.

KW - GC and GC-MS

KW - patient on INH-treatment

KW - quantitative analysis

KW - successive excretion of free hydrazine

KW - the metabolites in urine

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ER -

Quantitative determination of hydrazines derived from isoniazid in patients. I

Abstract

Keywords

ASJC Scopus subject areas

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