Quality of life assessment in Taiwanese patients with bone metastases from breast cancer receiving zoledronic acid

Ta Chung Chao; Dar Ren Chen; Tsu Yi Chao; Shin Cheh Chen; Dah Cherng Yeh; Hwei Chung Wang; Wen Tsung Huang; Kun Ming Rau; King Jen Chang; Tsen Long Yang; Kuan Der Lee; Cheng Jeng Tai; Ling Ming Tseng; Ming Feng Hou

Quality of life assessment in Taiwanese patients with bone metastases from breast cancer receiving zoledronic acid

Ta Chung Chao, Dar Ren Chen, Tsu Yi Chao, Shin Cheh Chen, Dah Cherng Yeh, Hwei Chung Wang, Wen Tsung Huang, Kun Ming Rau, King Jen Chang, Tsen Long Yang, Kuan Der Lee, Cheng Jeng Tai, Ling Ming Tseng, Ming Feng Hou

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Background: The current study aimed to examine the impact of zoledronic acid therapy on health-related quality of life (HRQoL) in Taiwanese patients with bone metastases from breast cancer. Patients and Methods: Patients with bone metastases from breast cancer who received zoledronic acid according to the standards of care were enrolled in this observational phase IV study. HRQoL was measured monthly using the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (QLQ-C30) and the breast cancer-specific module (BR-23) for 24 months. Results: A total of 366 patients from 13 centers were enrolled. QLQ C-30 demonstrated that zoledronic acid improved the HRQoL in different aspects. In particular, a significant reduction of pain in the first 14 months and the 22-month follow-up was reported by patients. QLQ-BR23 indicated improved future perspective and breast symptom scores over the course of the study. Conclusion: These data confirm the HRQoL benefits and safety of zoledronic acid in Taiwanese patients with bone metastases from breast cancer.

Original language	English
Pages (from-to)	5543-5548
Number of pages	6
Journal	Anticancer Research
Volume	33
Issue number	12
Publication status	Published - Dec 2013

Keywords

Bone metastases
Breast cancer
Quality of life
Zoledronic acid

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Quality of life assessment in Taiwanese patients with bone metastases from breast cancer receiving zoledronic acid",

abstract = "Background: The current study aimed to examine the impact of zoledronic acid therapy on health-related quality of life (HRQoL) in Taiwanese patients with bone metastases from breast cancer. Patients and Methods: Patients with bone metastases from breast cancer who received zoledronic acid according to the standards of care were enrolled in this observational phase IV study. HRQoL was measured monthly using the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (QLQ-C30) and the breast cancer-specific module (BR-23) for 24 months. Results: A total of 366 patients from 13 centers were enrolled. QLQ C-30 demonstrated that zoledronic acid improved the HRQoL in different aspects. In particular, a significant reduction of pain in the first 14 months and the 22-month follow-up was reported by patients. QLQ-BR23 indicated improved future perspective and breast symptom scores over the course of the study. Conclusion: These data confirm the HRQoL benefits and safety of zoledronic acid in Taiwanese patients with bone metastases from breast cancer.",

keywords = "Bone metastases, Breast cancer, Quality of life, Zoledronic acid",

author = "Chao, {Ta Chung} and Chen, {Dar Ren} and Chao, {Tsu Yi} and Chen, {Shin Cheh} and Yeh, {Dah Cherng} and Wang, {Hwei Chung} and Huang, {Wen Tsung} and Rau, {Kun Ming} and Chang, {King Jen} and Yang, {Tsen Long} and Lee, {Kuan Der} and Tai, {Cheng Jeng} and Tseng, {Ling Ming} and Hou, {Ming Feng}",

year = "2013",

month = dec,

language = "English",

volume = "33",

pages = "5543--5548",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "12",

}

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T1 - Quality of life assessment in Taiwanese patients with bone metastases from breast cancer receiving zoledronic acid

AU - Chao, Ta Chung

AU - Chen, Dar Ren

AU - Chao, Tsu Yi

AU - Chen, Shin Cheh

AU - Yeh, Dah Cherng

AU - Wang, Hwei Chung

AU - Huang, Wen Tsung

AU - Rau, Kun Ming

AU - Chang, King Jen

AU - Yang, Tsen Long

AU - Lee, Kuan Der

AU - Tai, Cheng Jeng

AU - Tseng, Ling Ming

AU - Hou, Ming Feng

PY - 2013/12

Y1 - 2013/12

N2 - Background: The current study aimed to examine the impact of zoledronic acid therapy on health-related quality of life (HRQoL) in Taiwanese patients with bone metastases from breast cancer. Patients and Methods: Patients with bone metastases from breast cancer who received zoledronic acid according to the standards of care were enrolled in this observational phase IV study. HRQoL was measured monthly using the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (QLQ-C30) and the breast cancer-specific module (BR-23) for 24 months. Results: A total of 366 patients from 13 centers were enrolled. QLQ C-30 demonstrated that zoledronic acid improved the HRQoL in different aspects. In particular, a significant reduction of pain in the first 14 months and the 22-month follow-up was reported by patients. QLQ-BR23 indicated improved future perspective and breast symptom scores over the course of the study. Conclusion: These data confirm the HRQoL benefits and safety of zoledronic acid in Taiwanese patients with bone metastases from breast cancer.

AB - Background: The current study aimed to examine the impact of zoledronic acid therapy on health-related quality of life (HRQoL) in Taiwanese patients with bone metastases from breast cancer. Patients and Methods: Patients with bone metastases from breast cancer who received zoledronic acid according to the standards of care were enrolled in this observational phase IV study. HRQoL was measured monthly using the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (QLQ-C30) and the breast cancer-specific module (BR-23) for 24 months. Results: A total of 366 patients from 13 centers were enrolled. QLQ C-30 demonstrated that zoledronic acid improved the HRQoL in different aspects. In particular, a significant reduction of pain in the first 14 months and the 22-month follow-up was reported by patients. QLQ-BR23 indicated improved future perspective and breast symptom scores over the course of the study. Conclusion: These data confirm the HRQoL benefits and safety of zoledronic acid in Taiwanese patients with bone metastases from breast cancer.

KW - Bone metastases

KW - Breast cancer

KW - Quality of life

KW - Zoledronic acid

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Quality of life assessment in Taiwanese patients with bone metastases from breast cancer receiving zoledronic acid

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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