Psychometric Evaluation of the Irritability Scale-Initial Version in Chinese Cancer Patients

Amy Y. Zhang, Lili Tang, Stephen Ganocy, Min Huey Chung, Wen Pei Chang

Research output: Contribution to journalArticlepeer-review


Background Irritability is a common experience of depressed Chinese patients but is understudied and poorly measured. Objective We aimed to assess psychometric properties of a new measure of irritability in Chinese cancer patients across the social and political spectrum. Methods The Irritability Scale-Initial Version (TISi) was translated into Chinese and tested in two samples of Chinese cancer patients undergoing treatments: 52 patients in Beijing, China, between 2018 and 2019 and 65 patients in Taipei, Taiwan, in 2020. Results The Chinese version of TISi demonstrated high internal consistency, high reliability based on the split-half method in the two samples, and satisfactory discriminant validity using the Chinese version of the 17-item Hamilton Rating Scale for Depression and the seven-item depression subscale of the Hospital Anxiety and Depression Scale in the Beijing sample. A confirmatory factor analysis produced factor loadings in both samples, which resembled a sample of American cancer patients. Three TISi items were loaded more highly on the physical instead of the original behavioral subscale in the Beijing sample. A possible influence of cultures was explained. Conclusion The Chinese version of TISi has satisfactory psychometric properties for assessing the level of irritability in Chinese cancer patients. Future large-sample studies are needed to further determine TISi's factorial structure, test-retest reliability, sensitivity to change, and predictive validity for depression in Chinese cancer patients.

Original languageEnglish
Pages (from-to)49-57
Number of pages9
JournalNursing Research
Issue number1
Publication statusPublished - Jan 1 2023


  • cancer
  • Chinese
  • depression
  • irritability
  • measurement

ASJC Scopus subject areas

  • General Medicine


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