TY - JOUR
T1 - Psoriasis is associated with an increased risk of parkinsonism
T2 - A population-based 5-year follow-up study
AU - Sheu, Jau-Jiuan
AU - Wang, Kuo-Hsien
AU - Lin, Herng-Ching
AU - Huang, Chung-Chien
PY - 2013/6
Y1 - 2013/6
N2 - Background: Few studies have examined the association between autoimmune diseases and parkinsonism. Objective: We sought to investigate the risk for parkinsonism during a 5-year follow-up period after a diagnosis of psoriasis using a population-based data set in Taiwan. Methods: We identified 4885 patients with psoriasis for the study cohort and randomly selected 24,425 patients as a control cohort. Each subject was individually followed up for a 5-year period to identify those who subsequently developed parkinsonism. Results: Stratified Cox proportional hazards regression showed that the adjusted hazard ratio for parkinsonism during the 5-year follow-up period for patients with psoriasis was 1.74 (95% confidence interval 1.35-2.20) that of control patients. Furthermore, the adjusted hazard ratios for parkinsonism within the 5-year follow-up period after the index date for subjects with psoriasis were similar between both sexes (1.78 and 1.66 for men and women, respectively). Limitation: Our data set did not provide detailed information on the severity of psoriasis, or individual factors such as cigarette smoking, alcohol consumption, body mass index, and dietary patterns. Conclusion: Patients with psoriasis were found to be at a significant risk of parkinsonism during a 5-year follow-up.
AB - Background: Few studies have examined the association between autoimmune diseases and parkinsonism. Objective: We sought to investigate the risk for parkinsonism during a 5-year follow-up period after a diagnosis of psoriasis using a population-based data set in Taiwan. Methods: We identified 4885 patients with psoriasis for the study cohort and randomly selected 24,425 patients as a control cohort. Each subject was individually followed up for a 5-year period to identify those who subsequently developed parkinsonism. Results: Stratified Cox proportional hazards regression showed that the adjusted hazard ratio for parkinsonism during the 5-year follow-up period for patients with psoriasis was 1.74 (95% confidence interval 1.35-2.20) that of control patients. Furthermore, the adjusted hazard ratios for parkinsonism within the 5-year follow-up period after the index date for subjects with psoriasis were similar between both sexes (1.78 and 1.66 for men and women, respectively). Limitation: Our data set did not provide detailed information on the severity of psoriasis, or individual factors such as cigarette smoking, alcohol consumption, body mass index, and dietary patterns. Conclusion: Patients with psoriasis were found to be at a significant risk of parkinsonism during a 5-year follow-up.
KW - Parkinson disease
KW - autoimmune disease
KW - cohort study
KW - epidemiology
KW - parkinsonism
KW - psoriasis
UR - http://www.scopus.com/inward/record.url?scp=84877830102&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84877830102&partnerID=8YFLogxK
U2 - 10.1016/j.jaad.2012.12.961
DO - 10.1016/j.jaad.2012.12.961
M3 - Article
C2 - 23374233
AN - SCOPUS:84877830102
SN - 0190-9622
VL - 68
SP - 992
EP - 999
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 6
ER -