Prussian Blue Derived Nanoporous Iron Oxides as Anticancer Drug Carriers for Magnetic-Guided Chemotherapy

Mohamed B. Zakaria; Alexei A. Belik; Chia Hung Liu; Han Yun Hsieh; Yu Te Liao; Victor Malgras; Yusuke Yamauchi; Kevin C.W. Wu

doi:10.1002/asia.201500232

Prussian Blue Derived Nanoporous Iron Oxides as Anticancer Drug Carriers for Magnetic-Guided Chemotherapy

Mohamed B. Zakaria, Alexei A. Belik, Chia Hung Liu, Han Yun Hsieh, Yu Te Liao, Victor Malgras, Yusuke Yamauchi, Kevin C.W. Wu

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

New nanoporous iron oxide nanoparticles with superparamagnetic behavior were successfully synthesized from Prussian blue (PB) nanocubes through a thermal conversion method and applied to the intracellular drug-delivery systems (DDS) of bladder cancer cells (i.e., T24) with controlled release and magnetic guiding properties. The results of the MTT assay and confocal laser scanning microscopy indicate that the synthesized iron oxide nanoparticles were successfully uptaken by T24 cells with excellent biocompatibility. An anticancer drug, that is, cisplatin, was used as a model drug, and its loading/release behavior was investigated. The intracellular drug delivery efficiency was greatly enhanced for the cisplatin-loaded, PB-derived, magnetic-guided drug-delivery system compared with the non-drug case. The synthesized nanomaterials show great potential as drug vehicles with high biocompatibility, controlled release, and magnetic targeting features for future intracellular DDS.

Original language	English
Pages (from-to)	1457-1462
Number of pages	6
Journal	Chemistry - An Asian Journal
Volume	10
Issue number	7
DOIs	https://doi.org/10.1002/asia.201500232
Publication status	Published - Jul 1 2015

Keywords

drug delivery
iron oxide
magnetic-guided chemotherapy
nanoparticles
Prussian blue

ASJC Scopus subject areas

Chemistry(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/asia.201500232

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title = "Prussian Blue Derived Nanoporous Iron Oxides as Anticancer Drug Carriers for Magnetic-Guided Chemotherapy",

abstract = "New nanoporous iron oxide nanoparticles with superparamagnetic behavior were successfully synthesized from Prussian blue (PB) nanocubes through a thermal conversion method and applied to the intracellular drug-delivery systems (DDS) of bladder cancer cells (i.e., T24) with controlled release and magnetic guiding properties. The results of the MTT assay and confocal laser scanning microscopy indicate that the synthesized iron oxide nanoparticles were successfully uptaken by T24 cells with excellent biocompatibility. An anticancer drug, that is, cisplatin, was used as a model drug, and its loading/release behavior was investigated. The intracellular drug delivery efficiency was greatly enhanced for the cisplatin-loaded, PB-derived, magnetic-guided drug-delivery system compared with the non-drug case. The synthesized nanomaterials show great potential as drug vehicles with high biocompatibility, controlled release, and magnetic targeting features for future intracellular DDS.",

keywords = "drug delivery, iron oxide, magnetic-guided chemotherapy, nanoparticles, Prussian blue",

author = "Zakaria, {Mohamed B.} and Belik, {Alexei A.} and Liu, {Chia Hung} and Hsieh, {Han Yun} and Liao, {Yu Te} and Victor Malgras and Yusuke Yamauchi and Wu, {Kevin C.W.}",

year = "2015",

month = jul,

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doi = "10.1002/asia.201500232",

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T1 - Prussian Blue Derived Nanoporous Iron Oxides as Anticancer Drug Carriers for Magnetic-Guided Chemotherapy

AU - Zakaria, Mohamed B.

AU - Belik, Alexei A.

AU - Liu, Chia Hung

AU - Hsieh, Han Yun

AU - Liao, Yu Te

AU - Malgras, Victor

AU - Yamauchi, Yusuke

AU - Wu, Kevin C.W.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - New nanoporous iron oxide nanoparticles with superparamagnetic behavior were successfully synthesized from Prussian blue (PB) nanocubes through a thermal conversion method and applied to the intracellular drug-delivery systems (DDS) of bladder cancer cells (i.e., T24) with controlled release and magnetic guiding properties. The results of the MTT assay and confocal laser scanning microscopy indicate that the synthesized iron oxide nanoparticles were successfully uptaken by T24 cells with excellent biocompatibility. An anticancer drug, that is, cisplatin, was used as a model drug, and its loading/release behavior was investigated. The intracellular drug delivery efficiency was greatly enhanced for the cisplatin-loaded, PB-derived, magnetic-guided drug-delivery system compared with the non-drug case. The synthesized nanomaterials show great potential as drug vehicles with high biocompatibility, controlled release, and magnetic targeting features for future intracellular DDS.

AB - New nanoporous iron oxide nanoparticles with superparamagnetic behavior were successfully synthesized from Prussian blue (PB) nanocubes through a thermal conversion method and applied to the intracellular drug-delivery systems (DDS) of bladder cancer cells (i.e., T24) with controlled release and magnetic guiding properties. The results of the MTT assay and confocal laser scanning microscopy indicate that the synthesized iron oxide nanoparticles were successfully uptaken by T24 cells with excellent biocompatibility. An anticancer drug, that is, cisplatin, was used as a model drug, and its loading/release behavior was investigated. The intracellular drug delivery efficiency was greatly enhanced for the cisplatin-loaded, PB-derived, magnetic-guided drug-delivery system compared with the non-drug case. The synthesized nanomaterials show great potential as drug vehicles with high biocompatibility, controlled release, and magnetic targeting features for future intracellular DDS.

KW - drug delivery

KW - iron oxide

KW - magnetic-guided chemotherapy

KW - nanoparticles

KW - Prussian blue

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Prussian Blue Derived Nanoporous Iron Oxides as Anticancer Drug Carriers for Magnetic-Guided Chemotherapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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