TY - JOUR
T1 - Proton pump inhibitor-related headaches
T2 - A nationwide population-based case-crossover study in Taiwan
AU - Liang, Jen Feng
AU - Chen, Yung Tai
AU - Fuh, Jong Ling
AU - Li, Szu Yuan
AU - Chen, Tzeng Ji
AU - Tang, Chao Hsiun
AU - Wang, Shuu Jiun
N1 - Publisher Copyright:
© International Headache Society 2014.
PY - 2015/3/26
Y1 - 2015/3/26
N2 - Background: Headaches resulting from proton pump inhibitor (PPI) use could cause discontinuation of PPI in as many as 40% of patients who experience such headaches. Previous studies focusing on acute headache risk from PPI use are rare and limited to clinical trials of a single PPI. Objectives: To investigate the association between PPI use and headache with a nationwide population-based case-crossover study. Methods: Records containing the first diagnosis of any headache, including migraine and tension-type headaches, were retrieved from Taiwan National Health Insurance Database (19982010).We compared the rates of PPI use for cases and controls during time windows of 7, 14, and 28 days. The adjusted self-matched odds ratios (ORs) and 95% confidence intervals (CIs) from a conditional logistic regression model were used to determine the association between PPI use and headache. Results: Overall, 314,210 patients with an initial diagnosis of any headache during the study period were enrolled. The adjusted ORs for headache risk after PPI exposure were calculated for three time periods (within 7 days1.41, p0.002, 95% CI 1.141.74; within 14 days1.36, p<0.001, 95% CI 1.161.59; within 28 days1.20, p0.002, 95% CI 1.071.35). Subgroup analyses showed female patients had an increased risk of headache. Among PPIs, lansoprazole and esomeprazole had the highest risks of headache incidence, which were similar to that of nitrates. Conclusion: PPI usage is associated with an increased risk for acute headache. Female patients and use of lansoprazole or esomeprazole present the greatest risks of headache.
AB - Background: Headaches resulting from proton pump inhibitor (PPI) use could cause discontinuation of PPI in as many as 40% of patients who experience such headaches. Previous studies focusing on acute headache risk from PPI use are rare and limited to clinical trials of a single PPI. Objectives: To investigate the association between PPI use and headache with a nationwide population-based case-crossover study. Methods: Records containing the first diagnosis of any headache, including migraine and tension-type headaches, were retrieved from Taiwan National Health Insurance Database (19982010).We compared the rates of PPI use for cases and controls during time windows of 7, 14, and 28 days. The adjusted self-matched odds ratios (ORs) and 95% confidence intervals (CIs) from a conditional logistic regression model were used to determine the association between PPI use and headache. Results: Overall, 314,210 patients with an initial diagnosis of any headache during the study period were enrolled. The adjusted ORs for headache risk after PPI exposure were calculated for three time periods (within 7 days1.41, p0.002, 95% CI 1.141.74; within 14 days1.36, p<0.001, 95% CI 1.161.59; within 28 days1.20, p0.002, 95% CI 1.071.35). Subgroup analyses showed female patients had an increased risk of headache. Among PPIs, lansoprazole and esomeprazole had the highest risks of headache incidence, which were similar to that of nitrates. Conclusion: PPI usage is associated with an increased risk for acute headache. Female patients and use of lansoprazole or esomeprazole present the greatest risks of headache.
KW - Headache
KW - Taiwan
KW - incidence
KW - proton pump inhibitor
KW - risk
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U2 - 10.1177/0333102414535114
DO - 10.1177/0333102414535114
M3 - Article
C2 - 24853165
AN - SCOPUS:84923932466
SN - 0333-1024
VL - 35
SP - 203
EP - 210
JO - Cephalalgia
JF - Cephalalgia
IS - 3
ER -