Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 3276-3287 |
| Number of pages | 12 |
| Journal | Food and Function |
| Volume | 8 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2017 |
| Externally published | Yes |
Keywords
- Amino acids
- Carbon tetrachloride
- Diseases
- Phosphatases
- Proteins
- Alanine aminotransferase
- Anticancer activities
- Epigallocatechin gallate
- Hepatic stellate cells
- Hepatoprotective effects
- Immunohistochemical staining
- Intraperitoneal injections
- Transforming growth factor beta
- Mammals
- benzopyran derivative
- carbon tetrachloride
- gelatinase B
- phenol derivative
- plant extract
- theasinensin A
- transforming growth factor beta1
- animal
- Camellia sinensis
- chemically induced
- chemistry
- disease model
- drug effects
- genetics
- human
- liver
- liver cirrhosis
- male
- metabolism
- mouse
- tea
- Animals
- Benzopyrans
- Carbon Tetrachloride
- Disease Models, Animal
- Humans
- Liver
- Liver Cirrhosis
- Male
- Matrix Metalloproteinase 9
- Mice
- Phenols
- Plant Extracts
- Tea
- Transforming Growth Factor beta1
Access to Document
Fingerprint
Dive into the research topics of 'Protective effects of theasinensin A against carbon tetrachloride-induced liver injury in mice'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS
In: Food and Function, Vol. 8, No. 9, 2017, p. 3276-3287.
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Protective effects of theasinensin A against carbon tetrachloride-induced liver injury in mice
AU - Hung, W.-L.
AU - Yang, G.
AU - Wang, Y.-C.
AU - Chiou, Y.-S.
AU - Tung, Y.-C.
AU - Yang, M.-J.
AU - Wang, B.-N.
AU - Ho, C.-T.
AU - Wang, Y.
AU - Pan, M.-H.
N1 - 引用次數:1 Export Date: 19 September 2018 通訊地址: Wang, Y.; Citrus Research and Education Center, Department of Food Science and Human Nutrition, University of FloridaUnited States; 電子郵件: [email protected] 化學物質/CAS: carbon tetrachloride, 56-23-5; gelatinase B, 146480-36-6; Benzopyrans; Carbon Tetrachloride; Matrix Metalloproteinase 9; Phenols; Plant Extracts; Tea; theasinensin A; Transforming Growth Factor beta1 出資詳情: 105-2320-B-002-031-MY3, MOST, Ministry of Science and Technology 出資詳情: 105-2628-B-002-003-MY3, MOST, Ministry of Science and Technology 出資正文: This study was supported by the Ministry of Science and Technology (105-2320-B-002-031-MY3 and 105-2628-B-002-003-MY3) and the Taiwan Tea Research and Extension Station. 參考文獻: Bataller, R., Brenner, D.A., Liver fibrosis (2005) J. Clin. Invest., 115, pp. 209-218; Friedman, S.L., Liver fibrosis - From bench to bedside (2003) J. Hepatol., 38, pp. S38-S53; Bissell, D.M., Chronic liver injury, TGF-beta, and cancer (2001) Exp. Mol. Med., 33, pp. 179-190; Hernandez-Gea, V., Friedman, S.L., Pathogenesis of Liver Fibrosis (2011) Annu. Rev. Pathol.: Mech. Dis., 6, pp. 425-456; Wynn, T.A., Ramalingam, T.R., Mechanisms of fibrosis: Therapeutic translation for fibrotic disease (2012) Nat. Med., 18, pp. 1028-1040; Derynck, R., Zhang, Y.E., Smad-dependent and Smad-independent pathways in TGF-beta family signalling (2003) Nature, 425, pp. 577-584; Meng, X.M., Nikolic-Paterson, D.J., Lan, H.Y., TGF-beta: The master regulator of fibrosis (2016) Nat. Rev. Nephrol., 12, pp. 325-338; Gressner, A.M., Weiskirchen, R., Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets (2006) J. Cell. Mol. Med., 10, pp. 76-99; Liu, X.J., Hu, H., Yin, J.Q., Therapeutic strategies against TGF-beta signaling pathway in hepatic fibrosis (2006) Liver Int., 26, pp. 8-22; Domitrovic, R., Potocnjak, I., A comprehensive overview of hepatoprotective natural compounds: Mechanism of action and clinical perspectives (2016) Arch. Toxicol., 90, pp. 39-79; Liu, M., Xu, Y.W., Han, X., Yin, L.H., Xu, L., Qi, Y., Zhao, Y.Y., Peng, J.Y., Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-kappa B signaling pathway (2015) Sci. Rep., 5, p. 18038; Gu, L.N., Tao, X.F., Xu, Y.W., Han, X., Qi, Y., Xu, L.N., Yin, L.H., Peng, J.Y., Dioscin alleviates BDL- and DMN-induced hepatic fibrosis via Sirt1/Nrf2-mediated inhibition of p38 MAPK pathway (2016) Toxicol. Appl. Pharmacol., 292, pp. 19-29; Bhakuni, G.S., Bedi, O., Bariwal, J., Deshmukh, R., Kumar, P., Animal models of hepatotoxicity (2016) Inflammation Res., 65, pp. 13-24; Tamayo, R.P., Is Cirrhosis of the Liver Experimentally Produced by Ccl4 an Adequate Model of Human Cirrhosis (1983) Hepatology, 3, pp. 112-120; Weber, L.W.D., Boll, M., Stampfl, A., Hepatotoxicity and mechanism of action of haloalkanes: Carbon tetrachloride as a toxicological model (2003) Crit. Rev. Toxicol., 33, pp. 105-136; Watanabe, T., Niioka, M., Hozawa, S., Kameyama, K., Hayashi, T., Arai, M., Ishikawa, A., Okazaki, I., Gene expression of interstitial collagenase in both progressive and recovery phase of rat liver fibrosis induced by carbon tetrachloride (2000) J. Hepatol., 33, pp. 224-235; Du, W.D., Zhang, Y.E., Zhai, W.R., Zhou, X.M., Dynamic changes of type I, III and IV collagen synthesis and distribution of collagen-producing cells in carbon tetrachloride-induced rat liver fibrosis (1999) World J. Gastroenterol., 5, pp. 397-403; Herbst, H., Wege, T., Milani, S., Pellegrini, G., Orzechowski, H.D., Bechstein, W.O., Neuhaus, P., Schuppan, D., Tissue inhibitor of metalloproteinase-1 and -2 RNA expression in rat and human liver fibrosis (1997) Am. J. Pathol., 150, pp. 1647-1659; Hashimoto, F., Nonaka, G., Nishioka, I., Tannins and Related-Compounds.69. Isolation and Structure Elucidation of B,B'-Linked Bisflavanoids, Theasinensins-D-G and Oolongtheanin from Oolong Tea (2) (1988) Chem. Pharm. Bull., 36, pp. 1676-1684; Weerawatanakorn, M., Hung, W.-L., Pan, M.-H., Li, S., Li, D., Wan, X., Ho, C.-T., Chemistry and health beneficial effects of oolong tea and theasinensins (2015) Food Sci. Hum. Wellness, 4, pp. 133-146; Hou, D.X., Masuzaki, S., Tanigawa, S., Hashimoto, F., Chen, J.H., Sogo, T., Fujii, M., Oolong Tea Theasinensins Attenuate Cyclooxygenase-2 Expression in Lipopolysaccharide (LPS)-Activated Mouse Macrophages: Structure-Activity Relationship and Molecular Mechanisms (2010) J. Agric. Food Chem., 58, pp. 12735-12743; Miyata, Y., Tamaru, S., Tanaka, T., Tamaya, K., Matsui, T., Nagata, Y., Tanaka, K., Theflavins and Theasinensin A Derived from Fermented Tea Have Antihyperglycemic and Hypotriacylglycerolemic Effects in KK-A(y) Mice and Sprague-Dawley Rats (2013) J. Agric. Food Chem., 61, pp. 9366-9372; Pan, M.H., Liang, Y.C., Lin-Shiau, S.Y., Zhu, N.Q., Ho, C.T., Lin, J.K., Induction of apoptosis by the oolong tea polyphenol theasinensin A through cytochrome c release and activation of caspase-9 and caspase-3 in human U937 cells (2000) J. Agric. Food Chem., 48, pp. 6337-6346; Yasuda, Y., Shimizu, M., Sakai, H., Iwasa, J., Kubota, M., Adachi, S., Osawa, Y., Moriwaki, H., (-)-Epigallocatechin gallate prevents carbon tetrachloride-induced rat hepatic fibrosis by inhibiting the expression of the PDGFRbeta and IGF-1R (2009) Chem.-Biol. Interact., 182, pp. 159-164; Tipoe, G.L., Leung, T.M., Liong, E.C., Lau, T.Y., Fung, M.L., Nanji, A.A., Epigallocatechin-3-gallate (EGCG) reduces liver inflammation, oxidative stress and fibrosis in carbon tetrachloride (CCl4)-induced liver injury in mice (2010) Toxicology, 273, pp. 45-52; Shii, T., Miyamoto, M., Matsuo, Y., Tanaka, T., Kouno, I., Biomimetic One-Pot Preparation of a Black Tea Polyphenol Theasinensin A from Epigallocatechin Gallate by Treatment with Copper(II) Chloride and Ascorbic Acid (2011) Chem. Pharm. Bull., 59, pp. 1183-1185; Kaviarasan, S., Viswanathan, P., Ravichandran, M.K., Anuradha, C.V., (-) epigallocatechin gallate (EGCG) prevents lipid changes and collagen abnormalities in chronic ethanol-fed rats (2008) Toxicol. Mech. Methods, 18, pp. 425-432; Thangapandiyan, S., Miltonprabu, S., Epigallocatechin gallate effectively ameliorates fluoride-induced oxidative stress and DNA damage in the liver of rats (2013) Can. J. Physiol. Pharmacol., 91, pp. 528-537; Specht, E., Kaemmerer, D., Sanger, J., Wirtz, R.M., Schulz, S., Lupp, A., Comparison of immunoreactive score, HER2/neu score and H score for the immunohistochemical evaluation of somatostatin receptors in bronchopulmonary neuroendocrine neoplasms (2015) Histopathology, 67, pp. 368-377; Farazi, P.A., DePinho, R.A., Hepatocellular carcinoma pathogenesis: From genes to environment (2006) Nat. Rev. Cancer, 6, pp. 674-687; Tsukamoto, H., Matsuoka, M., French, S.W., Experimental-Models of Hepatic-Fibrosis - A Review (1990) Semin. Liver Dis., 10, pp. 56-65; Rubin, E., Hutterer, F., Popper, H., Cell Proliferation and Fiber Formation in Chronic Carbon Tetrachloride Intoxication - A Morphologic and Chemical Study (1963) Am. J. Pathol., 42, pp. 715-728; Maher, J.J., McGuire, R.F., Extracellular-Matrix Gene-Expression Increases Preferentially in Rat Lipocytes and Sinusoidal Endothelial-Cells during Hepatic-Fibrosis Invivo (1990) J. Clin. Invest., 86, pp. 1641-1648; Iredale, J.P., Benyon, R.C., Arthur, M.J.P., Ferris, W.F., Alcolado, R., Winwood, P.J., Clark, N., Murphy, G., Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis (1996) Hepatology, 24, pp. 176-184; Pan, M.H., Tung, Y.C., Yang, G.L., Li, S.M., Ho, C.T., Molecular mechanisms of the anti-obesity effect of bioactive compounds in tea and coffee (2016) Food Funct., 7, pp. 4481-4491; Wolfram, S., Wang, Y., Thielecke, F., Anti-obesity effects of green tea: From bedside to bench (2006) Mol. Nutr. Food Res., 50, pp. 176-187; Martel, J., Ojcius, D.M., Chang, C.J., Lin, C.S., Lu, C.C., Ko, Y.F., Tseng, S.F., Young, J.D., Anti-obesogenic and antidiabetic effects of plants and mushrooms (2017) Nat. Rev. Endocrinol., 13, pp. 149-160; Kuo, K.L., Weng, M.S., Chiang, C.T., Tsai, Y.J., Lin-Shiau, S.Y., Lin, J.K., Comparative studies on the hypolipidemic and growth suppressive effects of oolong, black, pu-erh, and green tea leaves in rats (2005) J. Agric. Food Chem., 53, pp. 480-489; Nakai, M., Fukui, Y., Asami, S., Toyoda-Ono, Y., Iwashita, T., Shibata, H., Mitsunaga, T., Kiso, Y., Inhibitory effects of oolong tea polyphenols on pancreatic lipase in vitro (2005) J. Agric. Food Chem., 53, pp. 4593-4598; Muriel, P., Escobar, Y., Kupffer cells are responsible for liver cirrhosis induced by carbon tetrachloride (2003) J. Appl. Toxicol., 23, pp. 103-108; Ferenci, P., Dragosics, B., Dittrich, H., Frank, H., Benda, L., Lochs, H., Meryn, S., Schneider, B., Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver (1989) J. Hepatol., 9, pp. 105-113; Zhen, M.C., Wang, Q., Huang, X.H., Cao, L.Q., Chen, X.L., Sun, K., Liu, Y.J., Zhang, L.J., Green tea polyphenol epigallocatechin-3-gallate inhibits oxidative damage and preventive effects on carbon tetrachloride-induced hepatic fibrosis (2007) J. Nutr. Biochem., 18, pp. 795-805; Hashimoto, F., Ono, M., Masuoka, C., Ito, Y., Sakata, Y., Shimizu, K., Nonaka, G., Nohara, T., Evaluation of the anti-oxidative effect (in vitro) of tea polyphenols (2003) Biosci., Biotechnol., Biochem., 67, pp. 396-401; Tsai, P.H., Kan, N.B., Ho, S.C., Liu, C.C., Lin, C.C., Effects of Oolong tea supplementation on lipid peroxidation of athletes at rest and post-exhaustive exercise (2005) J. Food Sci., 70, pp. S581-S585; Akhlaghi, M., Non-alcoholic fatty liver disease: Beneficial effects of flavonoids (2016) Phytother. Res., 30, pp. 1559-1571; Dong, D.S., Xu, L.N., Yin, L.H., Qi, Y., Peng, J.Y., Naringin prevents carbon tetrachloride-induced acute liver injury in mice (2015) J. Funct. Foods, 12, pp. 179-191; Hisanaga, A., Ishida, H., Sakao, K., Sogo, T., Kumamoto, T., Hashimoto, F., Hou, D.X., Anti-inflammatory activity and molecular mechanism of Oolong tea theasinensin (2014) Food Funct., 5, pp. 1891-1897; Zamara, E., Galastri, S., Aleffi, S., Petrai, I., Aragno, M., Mastrocola, R., Novo, E., Marra, F., Prevention of severe toxic liver injury and oxidative stress in MCP-1-deficient mice (2007) J. Hepatol., 46, pp. 230-238; Qiu, J., Kitamura, Y., Miyata, Y., Tamaru, S., Tanaka, K., Tanaka, T., Matsui, T., Transepithelial transport of theasinensins through Caco-2 cell monolayers and their absorption in Sprague-Dawley rats after oral administration (2012) J. Agric. Food Chem., 60, pp. 8036-8043; Friedman, S.L., Molecular mechanisms of hepatic fibrosis and principles of therapy (1997) J. Gastroenterol., 32, pp. 424-430; Moreira, R.K., Hepatic stellate cells and liver fibrosis (2007) Arch. Pathol. Lab. Med., 131, pp. 1728-1734; Wellington, K., Jarvis, B., Silymarin: A review of its clinical properties in the management of hepatic disorders (2001) BioDrugs, 15, pp. 465-489; Saller, R., Meier, R., Brignoli, R., The use of silymarin in the treatment of liver diseases (2001) Drugs, 61, pp. 2035-2063; Domitrovic, R., Rashed, K., Cvijanovic, O., Vladimir-Knezevic, S., Skoda, M., Visnic, A., Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice (2015) Chem.-Biol. Interact., 230, pp. 21-29; Qiao, H., Han, H., Hong, D., Ren, Z., Chen, Y., Zhou, C., Protective effects of baicalin on carbon tetrachloride induced liver injury by activating PPARgamma and inhibiting TGFbeta1 (2011) Pharm. Biol., 49, pp. 38-45; Hemmann, S., Graf, J., Roderfeld, M., Roeb, E., Expression of MMPs and TIMPs in liver fibrosis - A systematic review with special emphasis on anti-fibrotic strategies (2007) J. Hepatol., 46, pp. 955-975
PY - 2017
Y1 - 2017
N2 - Theasinensins have been identified as a major group of unique catechin dimers mainly found in oolong tea and black tea. Among several types of theasinensins, theasinensin A (TSA), an epigallocatechin gallate (EGCG) dimer with an R-biphenyl bond, is the most abundant theasinensin prevalent in oolong tea. Previous studies have reported that TSA exhibits antioxidative, anti-inflammatory and anti-cancer activities in vitro and in vivo. However, little is known about the hepatoprotective effect of TSA. Thus, the aim of this study was to investigate the inhibitory effect of TSA on carbon tetrachloride (CCl4)-induced hepatic fibrosis in mice. After intraperitoneal injection of CCl4 for eight weeks, histological lesions in the liver tissue and elevated serum levels of alanine aminotransferase and alkaline phosphatase were found in mice. Conversely, oral administration of TSA relieved CCl4-induced liver injury as well as ameliorated liver functions. Our immunohistochemical staining results revealed that collagen deposition was profoundly reduced due to supplementation with TSA. In addition, we also found that hepatic α-smooth muscle actin (α-SMA) and matrix metallopeptidase 9 (MMP-9) expression was suppressed through the inhibition of transforming growth factor β (TGF-β). Taken together, our current findings suggest that TSA may serve as a potent bioactive constituent from oolong tea that acts against liver fibrosis through the inhibition of hepatic stellate cell (HSC) activation. © 2017 The Royal Society of Chemistry.
AB - Theasinensins have been identified as a major group of unique catechin dimers mainly found in oolong tea and black tea. Among several types of theasinensins, theasinensin A (TSA), an epigallocatechin gallate (EGCG) dimer with an R-biphenyl bond, is the most abundant theasinensin prevalent in oolong tea. Previous studies have reported that TSA exhibits antioxidative, anti-inflammatory and anti-cancer activities in vitro and in vivo. However, little is known about the hepatoprotective effect of TSA. Thus, the aim of this study was to investigate the inhibitory effect of TSA on carbon tetrachloride (CCl4)-induced hepatic fibrosis in mice. After intraperitoneal injection of CCl4 for eight weeks, histological lesions in the liver tissue and elevated serum levels of alanine aminotransferase and alkaline phosphatase were found in mice. Conversely, oral administration of TSA relieved CCl4-induced liver injury as well as ameliorated liver functions. Our immunohistochemical staining results revealed that collagen deposition was profoundly reduced due to supplementation with TSA. In addition, we also found that hepatic α-smooth muscle actin (α-SMA) and matrix metallopeptidase 9 (MMP-9) expression was suppressed through the inhibition of transforming growth factor β (TGF-β). Taken together, our current findings suggest that TSA may serve as a potent bioactive constituent from oolong tea that acts against liver fibrosis through the inhibition of hepatic stellate cell (HSC) activation. © 2017 The Royal Society of Chemistry.
KW - Amino acids
KW - Carbon tetrachloride
KW - Diseases
KW - Phosphatases
KW - Proteins
KW - Alanine aminotransferase
KW - Anticancer activities
KW - Epigallocatechin gallate
KW - Hepatic stellate cells
KW - Hepatoprotective effects
KW - Immunohistochemical staining
KW - Intraperitoneal injections
KW - Transforming growth factor beta
KW - Mammals
KW - benzopyran derivative
KW - carbon tetrachloride
KW - gelatinase B
KW - phenol derivative
KW - plant extract
KW - theasinensin A
KW - transforming growth factor beta1
KW - animal
KW - Camellia sinensis
KW - chemically induced
KW - chemistry
KW - disease model
KW - drug effects
KW - genetics
KW - human
KW - liver
KW - liver cirrhosis
KW - male
KW - metabolism
KW - mouse
KW - tea
KW - Animals
KW - Benzopyrans
KW - Carbon Tetrachloride
KW - Disease Models, Animal
KW - Humans
KW - Liver
KW - Liver Cirrhosis
KW - Male
KW - Matrix Metalloproteinase 9
KW - Mice
KW - Phenols
KW - Plant Extracts
KW - Tea
KW - Transforming Growth Factor beta1
U2 - 10.1039/c7fo00700k
DO - 10.1039/c7fo00700k
M3 - Article
SN - 2042-6496
VL - 8
SP - 3276
EP - 3287
JO - Food and Function
JF - Food and Function
IS - 9
ER -