Abstract
The American ginseng (Panax quinquefolium L.) is widely used in the oriental traditional medicine. The present study investigates the protection effects of Panax quinquefolium extract granule (PQEG) against chemical-induced gastric mucosal injury. In vitro cell damage was induced by incubating rat gastric mucosal cells, RGM1, with indomethacin (INDO) and quantitated by methylthiazole-tetrazolium (MTT) assay. In vivo gastric damage was induced by 70 % ethanol 10 mL/kg and the ulcer index was calculated the gastric mucosal damage percentage. In vitro study, Panax quinquefolium extract granule revealed significant protection on rat gastric mucosal cells, RGM1, from indomethacin-caused cytotoxicity, with an EC50 of 694.4 mg/kg (95 % CL: 582.2-872.6). In vivo studies showed pretreatment with Panax quinquefolium extract granule caused a significant and dose-dependent inhibition of ethanol-induced gastric mucosal damage, with an ED50 of 588.7 mg/kg (95 % CL: 426.8-850.3). In conclusion, Panax quinquefolium treatment shows protective role in indomethacin- induced gastric mucosa cell injury in vitro and ethanol-induced gastric mucosa lesions in vivo.
| Original language | English |
|---|---|
| Pages (from-to) | 843-846 |
| Number of pages | 4 |
| Journal | Asian Journal of Chemistry |
| Volume | 24 |
| Issue number | 2 |
| Publication status | Published - 2012 |
Keywords
- American ginseng
- Ethanol
- Gastric mucosal injury
- Indomethacin
- Panax quinquefolium
- RGM1
ASJC Scopus subject areas
- General Chemistry