@article{dfa731ccf33f49aaa15e4a6a78497103,
title = "Protective effect of Grewia asiatica leaves extract in animal models of epilepsy and anxiety",
abstract = "Grewia asiatica Linn. is a well-known plant for its nutritional and therapeutic attributes. It has been mentioned in ancient Indian literature as Rasayana due to its stimulant and tonic effects. Thus, present investigation was carried out to evaluate the antiepileptic and anxiolytic action of G. asiatica Linn. leaves using animal models. Methanol extract at dose levels of 100 and 200 mg/kg was capable of providing protection against both pentylenetetrazole and maximal electroshock induced seizures in mice. Extract also showed significant anxiolytic activity in elevated plus maze, light/dark box and mirror chamber mice models at same dose levels. Results of this study indicated that the methanol extract of leaves of G. asiatica plant possess significant antiepileptic and anxiolytic effect.",
keywords = "Antiepileptic, Anxiolytic, Flavonoids, Grewia asiatica",
author = "Shabnampreet Kaur and Atamjit Singh and Hasandeep Singh and {Singh Bedi}, {Preet Mohinder} and Kunal Nepali and Balbir Singh and Sarabjit Kaur",
note = "Funding Information: This work was supported by the Office of Naval Research (award N000141812258) and the National Science Foundation (award CMMI-1752172). We acknowledge the Center for Materials Science and Engineering (CMSE), DMSE NanoLab, Biophysical Instrumentation Facility (BIF), Institute for Soldier Nanotechnologies (ISN), and Microsystems Technology Laboratories (MTL), all at MIT, and Center for Nanoscale Systems (CNS) at Harvard University for access to the characterization instruments. We thank A. Lytton-Jean and D.S. Yun at Koch Institute (MIT) for assistance with cryo-EM imaging, and T. Walsh at Asylum Research for assistance with nanomechanical measurements in liquid environment. We also acknowledge support from the Paul N. Cook Career Development Professorship and MIT Presidential Graduate Fellowship. Funding Information: This work was supported by the Office of Naval Research (award N000141812258) and the National Science Foundation (award CMMI-1752172). Publisher Copyright: {\textcopyright} 2022 The Authors",
year = "2022",
month = jul,
doi = "10.1016/j.jaim.2022.100616",
language = "English",
volume = "13",
journal = "Journal of Ayurveda and Integrative Medicine",
issn = "0975-9476",
publisher = "Elsevier B.V.",
number = "3",
}