TY - JOUR
T1 - Prospects of siRNA applications in regenerative medicine
AU - Mottaghitalab, Fatemeh
AU - Rastegari, Ali
AU - Farokhi, Mehdi
AU - Dinarvand, Rassoul
AU - Hosseinkhani, Hossein
AU - Ou, Keng Liang
AU - Pack, Daniel W.
AU - Mao, Chuanbin
AU - Dinarvand, Meshkat
AU - Fatahi, Yousef
AU - Atyabi, Fatemeh
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/5/30
Y1 - 2017/5/30
N2 - Small interfering RNA (siRNA) has established its reputation in the field of tissue engineering owing to its ability to silence the proteins that inhibit tissue regeneration. siRNA is capable of regulating cellular behavior during tissue regeneration processes. The concept of using siRNA technology in regenerative medicine derived from its ability to inhibit the expression of target genes involved in defective tissues and the possibility to induce the expression of tissue-inductive factors that improve the tissue regeneration process. To date, siRNA has been used as a suppressive biomolecule in different tissues, such as nervous tissue, bone, cartilage, heart, kidney, and liver. Moreover, various delivery systems have been applied in order to deliver siRNA to the target tissues. This review will provide an in-depth discussion on the development of siRNA and their delivery systems and mechanisms of action in different tissues.
AB - Small interfering RNA (siRNA) has established its reputation in the field of tissue engineering owing to its ability to silence the proteins that inhibit tissue regeneration. siRNA is capable of regulating cellular behavior during tissue regeneration processes. The concept of using siRNA technology in regenerative medicine derived from its ability to inhibit the expression of target genes involved in defective tissues and the possibility to induce the expression of tissue-inductive factors that improve the tissue regeneration process. To date, siRNA has been used as a suppressive biomolecule in different tissues, such as nervous tissue, bone, cartilage, heart, kidney, and liver. Moreover, various delivery systems have been applied in order to deliver siRNA to the target tissues. This review will provide an in-depth discussion on the development of siRNA and their delivery systems and mechanisms of action in different tissues.
KW - Delivery systems
KW - Gene expression
KW - siRNA
KW - Tissue engineering
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U2 - 10.1016/j.ijpharm.2017.03.092
DO - 10.1016/j.ijpharm.2017.03.092
M3 - Review article
C2 - 28385649
AN - SCOPUS:85017368427
SN - 0378-5173
VL - 524
SP - 312
EP - 329
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1-2
ER -