TY - JOUR
T1 - Prospects of primary ovarian insufficiency patient-specific pluripotent stem cells for disease modeling and clinical impacts
AU - Chen, Hsin Fu
AU - Ho, Hong Nerng
N1 - Funding Information:
We would like to acknowledge the support of Dr. Kuo HC for the experiments reported in this report. We also want to thank the Ph.D. students in the Lab, Miss Yu-An Chen and Miss Chen-Yu Lu for the preparation of the Figures. This report has been supported by the Grants from Ministry of Science and Technology (MOST) and National Science Council of Taiwan (NSC) (MOST 104-2321-B-002-046, NSC and NSC 102-2321-B-002-092-MY3), from National Taiwan University Hospital (NTUH; 105-S3001) and also the generous research budget donation from Mr. Ted Wen.
Publisher Copyright:
© 2018 Bentham Science Publishers.
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Background: Primary ovarian insufficiency (POI) or premature ovarian failure (POF) is defined by spontaneous amenorrhea with elevated serum gonadotropin levels and reduced estradiol level. POI frequently leads to reduced fertility and a number of clinical symptoms or signs related to premature menopause. The etiologies of POI include genetic or chromosomal defects, autoimmune factors, environmental factors, and idiopathic causes. However, the pathogenesis of POI is difficult to study due to a lack of suitable disease models. Recent evidence suggests that pluripotent stem cells (PSCs), including embryonic stem (ES) cells and induced pluripotent stem (iPS) cells, can be induced into germ cells and granulosa cells. Specifically, mouse PSCs can be directed to functional sperm and oocytes that lead to viable and fertile offspring. However, in humans, only early germ cells have been derived, including female primordial germ cells and immature haploid male germ cells with meiotic potential. Some evidence also suggests defective differentiation potential into germ cells and granulosa cells from POI patient-specific iPS cells (by reprogramming somatic cells from POI patients). Objective and Results: This report reviews current studies, advances, and future prospects in the derivation of POI patient-specific iPS cells, the efficiency of differentiating iPS cells into functional and mature germ cells and granulosa cells, and the potential to use the entire process as a disease model to screen drugs, toxicants and toxins. Conclusion: It is concluded that current data have provided good evidence to support the use of POI patient-specific iPS cells to model human POI and potentially other reproductive disorders.
AB - Background: Primary ovarian insufficiency (POI) or premature ovarian failure (POF) is defined by spontaneous amenorrhea with elevated serum gonadotropin levels and reduced estradiol level. POI frequently leads to reduced fertility and a number of clinical symptoms or signs related to premature menopause. The etiologies of POI include genetic or chromosomal defects, autoimmune factors, environmental factors, and idiopathic causes. However, the pathogenesis of POI is difficult to study due to a lack of suitable disease models. Recent evidence suggests that pluripotent stem cells (PSCs), including embryonic stem (ES) cells and induced pluripotent stem (iPS) cells, can be induced into germ cells and granulosa cells. Specifically, mouse PSCs can be directed to functional sperm and oocytes that lead to viable and fertile offspring. However, in humans, only early germ cells have been derived, including female primordial germ cells and immature haploid male germ cells with meiotic potential. Some evidence also suggests defective differentiation potential into germ cells and granulosa cells from POI patient-specific iPS cells (by reprogramming somatic cells from POI patients). Objective and Results: This report reviews current studies, advances, and future prospects in the derivation of POI patient-specific iPS cells, the efficiency of differentiating iPS cells into functional and mature germ cells and granulosa cells, and the potential to use the entire process as a disease model to screen drugs, toxicants and toxins. Conclusion: It is concluded that current data have provided good evidence to support the use of POI patient-specific iPS cells to model human POI and potentially other reproductive disorders.
KW - Embryonic stem cells
KW - Germ cells
KW - Granulosa cells
KW - Induced pluripotent stem cells
KW - Oocytes
KW - Premature ovarian failure
KW - Primary ovarian insufficiency
KW - Sperm
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U2 - 10.2174/1573404813666170929121848
DO - 10.2174/1573404813666170929121848
M3 - Review article
AN - SCOPUS:85042801035
SN - 1573-4048
VL - 14
SP - 67
EP - 80
JO - Current Women's Health Reviews
JF - Current Women's Health Reviews
IS - 1
ER -