Prospective Therapeutic Applications of Platelet Extracellular Vesicles

Jancy Johnson; Yu Wen Wu; Chantelle Blyth; Gregor Lichtfuss; Hadi Goubran; Thierry Burnouf

doi:10.1016/j.tibtech.2020.10.004

Prospective Therapeutic Applications of Platelet Extracellular Vesicles

Jancy Johnson, Yu Wen Wu, Chantelle Blyth, Gregor Lichtfuss, Hadi Goubran, Thierry Burnouf

Research output: Contribution to journal › Review article › peer-review

89 Citations (Scopus)

Abstract

There is much interest in the use of extracellular vesicles (EVs) as a subcellular therapy for regenerative medicine and drug delivery. Blood-borne platelets represent a source of therapeutic EVs that is so far largely unexplored. Advantages of platelets as a cellular source of EVs include their established clinical value, regulated collection procedures, availability in a concentrated form, propensity to generate EVs, and unique composition and tissue-targeting capacity. This review analyzes the unique potential of platelet-derived (p-) EVs as therapeutic modalities and presents their inherent translational advantages for hemostasis, for regenerative medicine, and as drug-delivery vehicles.

Original language	English
Pages (from-to)	598-612
Number of pages	15
Journal	Trends in Biotechnology
Volume	39
Issue number	6
DOIs	https://doi.org/10.1016/j.tibtech.2020.10.004
Publication status	Published - Jun 2021

Keywords

drug delivery
exosome
extracellular vesicle
platelet
regeneration

ASJC Scopus subject areas

Biotechnology
Bioengineering

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10.1016/j.tibtech.2020.10.004

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title = "Prospective Therapeutic Applications of Platelet Extracellular Vesicles",

abstract = "There is much interest in the use of extracellular vesicles (EVs) as a subcellular therapy for regenerative medicine and drug delivery. Blood-borne platelets represent a source of therapeutic EVs that is so far largely unexplored. Advantages of platelets as a cellular source of EVs include their established clinical value, regulated collection procedures, availability in a concentrated form, propensity to generate EVs, and unique composition and tissue-targeting capacity. This review analyzes the unique potential of platelet-derived (p-) EVs as therapeutic modalities and presents their inherent translational advantages for hemostasis, for regenerative medicine, and as drug-delivery vehicles.",

keywords = "drug delivery, exosome, extracellular vesicle, platelet, regeneration",

author = "Jancy Johnson and Wu, {Yu Wen} and Chantelle Blyth and Gregor Lichtfuss and Hadi Goubran and Thierry Burnouf",

note = "Funding Information: This study was supported by a grant ( 109–2314-B-038-126 ) from the Ministry of Science and Technology (MOST) of Taiwan and one ( NHRI-EX109-10920EI ) from the National Health Research Institute (NHRI) of Taiwan to T.B., Taipei Medical University (Taipei, Taiwan). Figures were created with objects sourced from Servier Medical Art ( http://smart.servier.com/ ), licensed under a Creative Commons Attribution 3.0 Generic License. Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2021",

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doi = "10.1016/j.tibtech.2020.10.004",

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AU - Johnson, Jancy

AU - Wu, Yu Wen

AU - Blyth, Chantelle

AU - Lichtfuss, Gregor

AU - Goubran, Hadi

AU - Burnouf, Thierry

N1 - Funding Information: This study was supported by a grant ( 109–2314-B-038-126 ) from the Ministry of Science and Technology (MOST) of Taiwan and one ( NHRI-EX109-10920EI ) from the National Health Research Institute (NHRI) of Taiwan to T.B., Taipei Medical University (Taipei, Taiwan). Figures were created with objects sourced from Servier Medical Art ( http://smart.servier.com/ ), licensed under a Creative Commons Attribution 3.0 Generic License. Publisher Copyright: © 2020 Elsevier Ltd Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2021/6

Y1 - 2021/6

N2 - There is much interest in the use of extracellular vesicles (EVs) as a subcellular therapy for regenerative medicine and drug delivery. Blood-borne platelets represent a source of therapeutic EVs that is so far largely unexplored. Advantages of platelets as a cellular source of EVs include their established clinical value, regulated collection procedures, availability in a concentrated form, propensity to generate EVs, and unique composition and tissue-targeting capacity. This review analyzes the unique potential of platelet-derived (p-) EVs as therapeutic modalities and presents their inherent translational advantages for hemostasis, for regenerative medicine, and as drug-delivery vehicles.

AB - There is much interest in the use of extracellular vesicles (EVs) as a subcellular therapy for regenerative medicine and drug delivery. Blood-borne platelets represent a source of therapeutic EVs that is so far largely unexplored. Advantages of platelets as a cellular source of EVs include their established clinical value, regulated collection procedures, availability in a concentrated form, propensity to generate EVs, and unique composition and tissue-targeting capacity. This review analyzes the unique potential of platelet-derived (p-) EVs as therapeutic modalities and presents their inherent translational advantages for hemostasis, for regenerative medicine, and as drug-delivery vehicles.

KW - drug delivery

KW - exosome

KW - extracellular vesicle

KW - platelet

KW - regeneration

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Prospective Therapeutic Applications of Platelet Extracellular Vesicles

Abstract

Keywords

ASJC Scopus subject areas

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