There is much interest in the use of extracellular vesicles (EVs) as a subcellular therapy for regenerative medicine and drug delivery. Blood-borne platelets represent a source of therapeutic EVs that is so far largely unexplored. Advantages of platelets as a cellular source of EVs include their established clinical value, regulated collection procedures, availability in a concentrated form, propensity to generate EVs, and unique composition and tissue-targeting capacity. This review analyzes the unique potential of platelet-derived (p-) EVs as therapeutic modalities and presents their inherent translational advantages for hemostasis, for regenerative medicine, and as drug-delivery vehicles.

Original languageEnglish
Pages (from-to)598-612
Number of pages15
JournalTrends in Biotechnology
Issue number6
Publication statusPublished - Jun 2021


  • drug delivery
  • exosome
  • extracellular vesicle
  • platelet
  • regeneration

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering


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