Proliferating cell nuclear antigen (PCNA) immunolabeling as a prognostic factor in invasive ductal carcinoma of the breast in Taiwan

Jan Show Chu; Chiun Sheng Huang; King Jen Chang

doi:10.1016/S0304-3835(98)00118-9

Proliferating cell nuclear antigen (PCNA) immunolabeling as a prognostic factor in invasive ductal carcinoma of the breast in Taiwan

Jan Show Chu, Chiun Sheng Huang, King Jen Chang

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

To evaluate the prognostic significance of proliferating cell nuclear antigen (PCNA) in breast cancer, an immunohistochemical assay was performed in 150 patients with invasive ductal carcinomas. The PCNA labeling index (PCNA-LI) was classified into two subgroups at a cut-off point of 45% that gave the best prognostic estimates for PCNA in survival analyses. Seventy-eight tumors had a low PCNA-LI of ≤45% and 72 tumors had a high PCNA-LI of >45%. A high PCNA-LI correlated significantly with p53 overexpression (P

Original language	English
Pages (from-to)	145-152
Number of pages	8
Journal	Cancer Letters
Volume	131
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(98)00118-9
Publication status	Published - Sept 25 1998
Externally published	Yes

Keywords

Breast cancer
Immunohistochemistry
p53
PCNA

ASJC Scopus subject areas

Cancer Research
Molecular Biology
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(98)00118-9

Cite this

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title = "Proliferating cell nuclear antigen (PCNA) immunolabeling as a prognostic factor in invasive ductal carcinoma of the breast in Taiwan",

abstract = "To evaluate the prognostic significance of proliferating cell nuclear antigen (PCNA) in breast cancer, an immunohistochemical assay was performed in 150 patients with invasive ductal carcinomas. The PCNA labeling index (PCNA-LI) was classified into two subgroups at a cut-off point of 45% that gave the best prognostic estimates for PCNA in survival analyses. Seventy-eight tumors had a low PCNA-LI of ≤45% and 72 tumors had a high PCNA-LI of >45%. A high PCNA-LI correlated significantly with p53 overexpression (P",

keywords = "Breast cancer, Immunohistochemistry, p53, PCNA",

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AU - Chu, Jan Show

AU - Huang, Chiun Sheng

AU - Chang, King Jen

PY - 1998/9/25

Y1 - 1998/9/25

N2 - To evaluate the prognostic significance of proliferating cell nuclear antigen (PCNA) in breast cancer, an immunohistochemical assay was performed in 150 patients with invasive ductal carcinomas. The PCNA labeling index (PCNA-LI) was classified into two subgroups at a cut-off point of 45% that gave the best prognostic estimates for PCNA in survival analyses. Seventy-eight tumors had a low PCNA-LI of ≤45% and 72 tumors had a high PCNA-LI of >45%. A high PCNA-LI correlated significantly with p53 overexpression (P

AB - To evaluate the prognostic significance of proliferating cell nuclear antigen (PCNA) in breast cancer, an immunohistochemical assay was performed in 150 patients with invasive ductal carcinomas. The PCNA labeling index (PCNA-LI) was classified into two subgroups at a cut-off point of 45% that gave the best prognostic estimates for PCNA in survival analyses. Seventy-eight tumors had a low PCNA-LI of ≤45% and 72 tumors had a high PCNA-LI of >45%. A high PCNA-LI correlated significantly with p53 overexpression (P

KW - Breast cancer

KW - Immunohistochemistry

KW - p53

KW - PCNA

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Proliferating cell nuclear antigen (PCNA) immunolabeling as a prognostic factor in invasive ductal carcinoma of the breast in Taiwan

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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