Abstract
To evaluate the prognostic significance of proliferating cell nuclear antigen (PCNA) in breast cancer, an immunohistochemical assay was performed in 150 patients with invasive ductal carcinomas. The PCNA labeling index (PCNA-LI) was classified into two subgroups at a cut-off point of 45% that gave the best prognostic estimates for PCNA in survival analyses. Seventy-eight tumors had a low PCNA-LI of ≤45% and 72 tumors had a high PCNA-LI of >45%. A high PCNA-LI correlated significantly with p53 overexpression (P
Original language | English |
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Pages (from-to) | 145-152 |
Number of pages | 8 |
Journal | Cancer Letters |
Volume | 131 |
Issue number | 2 |
DOIs | |
Publication status | Published - Sept 25 1998 |
Externally published | Yes |
Keywords
- Breast cancer
- Immunohistochemistry
- p53
- PCNA
ASJC Scopus subject areas
- Cancer Research
- Molecular Biology
- Oncology