Prognostic value of pretreatment CD44 mRNA in peripheral blood of patients with locally advanced head and neck cancer

Jen Tsun Lin; Tung Hao Chang; Cheng Shong Chang; Wen Hong Wang; Bi Wen Su; Kuan Der Lee; Pey Jium Chang

doi:10.1016/j.oraloncology.2010.02.011

Prognostic value of pretreatment CD44 mRNA in peripheral blood of patients with locally advanced head and neck cancer

Jen Tsun Lin, Tung Hao Chang, Cheng Shong Chang, Wen Hong Wang, Bi Wen Su, Kuan Der Lee, Pey Jium Chang

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

This study investigates the clinical significance of CD44 messenger RNA (mRNA) expression in the peripheral blood of patients with head and neck cancer. Real-time reverse transcriptase-polymerase chain reaction analysis was used to quantify CD44 mRNA levels in the peripheral blood of patients with locally advanced head and neck cancer. All patients were enrolled between January 2006 and December 2008 and had received chemotherapy/radiotherapy for their head and neck cancers. The pretreatment CD44 mRNA levels at a cutoff point of greater than fivefold were associated with an odds ratio of 12.5 for poor prognosis (95% CI, 3.9-40; p < 0.001) and could predict poor treatment response in patients with locally advanced head and neck cancers. Larger prospective studies comparing the current assay with standardized methodologies are warranted.

Original language	English
Pages (from-to)	e29-e33
Journal	Oral Oncology
Volume	46
Issue number	5
DOIs	https://doi.org/10.1016/j.oraloncology.2010.02.011
Publication status	Published - May 2010
Externally published	Yes

Keywords

CD44 mRNA
Head and neck cancer
Oral cancer
Quantitative RT-PCR

ASJC Scopus subject areas

Oral Surgery
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.oraloncology.2010.02.011

Cite this

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title = "Prognostic value of pretreatment CD44 mRNA in peripheral blood of patients with locally advanced head and neck cancer",

abstract = "This study investigates the clinical significance of CD44 messenger RNA (mRNA) expression in the peripheral blood of patients with head and neck cancer. Real-time reverse transcriptase-polymerase chain reaction analysis was used to quantify CD44 mRNA levels in the peripheral blood of patients with locally advanced head and neck cancer. All patients were enrolled between January 2006 and December 2008 and had received chemotherapy/radiotherapy for their head and neck cancers. The pretreatment CD44 mRNA levels at a cutoff point of greater than fivefold were associated with an odds ratio of 12.5 for poor prognosis (95% CI, 3.9-40; p < 0.001) and could predict poor treatment response in patients with locally advanced head and neck cancers. Larger prospective studies comparing the current assay with standardized methodologies are warranted.",

keywords = "CD44 mRNA, Head and neck cancer, Oral cancer, Quantitative RT-PCR",

author = "Lin, {Jen Tsun} and Chang, {Tung Hao} and Chang, {Cheng Shong} and Wang, {Wen Hong} and Su, {Bi Wen} and Lee, {Kuan Der} and Chang, {Pey Jium}",

year = "2010",

month = may,

doi = "10.1016/j.oraloncology.2010.02.011",

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T1 - Prognostic value of pretreatment CD44 mRNA in peripheral blood of patients with locally advanced head and neck cancer

AU - Lin, Jen Tsun

AU - Chang, Tung Hao

AU - Chang, Cheng Shong

AU - Wang, Wen Hong

AU - Su, Bi Wen

AU - Lee, Kuan Der

AU - Chang, Pey Jium

PY - 2010/5

Y1 - 2010/5

N2 - This study investigates the clinical significance of CD44 messenger RNA (mRNA) expression in the peripheral blood of patients with head and neck cancer. Real-time reverse transcriptase-polymerase chain reaction analysis was used to quantify CD44 mRNA levels in the peripheral blood of patients with locally advanced head and neck cancer. All patients were enrolled between January 2006 and December 2008 and had received chemotherapy/radiotherapy for their head and neck cancers. The pretreatment CD44 mRNA levels at a cutoff point of greater than fivefold were associated with an odds ratio of 12.5 for poor prognosis (95% CI, 3.9-40; p < 0.001) and could predict poor treatment response in patients with locally advanced head and neck cancers. Larger prospective studies comparing the current assay with standardized methodologies are warranted.

AB - This study investigates the clinical significance of CD44 messenger RNA (mRNA) expression in the peripheral blood of patients with head and neck cancer. Real-time reverse transcriptase-polymerase chain reaction analysis was used to quantify CD44 mRNA levels in the peripheral blood of patients with locally advanced head and neck cancer. All patients were enrolled between January 2006 and December 2008 and had received chemotherapy/radiotherapy for their head and neck cancers. The pretreatment CD44 mRNA levels at a cutoff point of greater than fivefold were associated with an odds ratio of 12.5 for poor prognosis (95% CI, 3.9-40; p < 0.001) and could predict poor treatment response in patients with locally advanced head and neck cancers. Larger prospective studies comparing the current assay with standardized methodologies are warranted.

KW - CD44 mRNA

KW - Head and neck cancer

KW - Oral cancer

KW - Quantitative RT-PCR

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Prognostic value of pretreatment CD44 mRNA in peripheral blood of patients with locally advanced head and neck cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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