Prognostic significance of global histone modifications in resected squamous cell carcinoma of the esophagus

Ching Tzao; Ho J. Tung; Jong Shiaw Jin; Guang Huan Sun; Han Shui Hsu; Ban H. Chen; Cheng Ping Yu; Shih Chun Lee

doi:10.1038/modpathol.2008.172

Prognostic significance of global histone modifications in resected squamous cell carcinoma of the esophagus

Ching Tzao, Ho J. Tung, Jong Shiaw Jin, Guang Huan Sun, Han Shui Hsu, Ban H. Chen, Cheng Ping Yu, Shih Chun Lee

Research output: Contribution to journal › Article › peer-review

97 Citations (Scopus)

Abstract

Patterns of global histone modifications have been recently suggested as outcome predictors in cancer patients. To date, there has been no report on the prognostic significance of global histone modifications in esophageal squamous cell carcinoma. We investigated the role of global histone modification as outcome predictor in patients undergoing esophagectomy for esophageal squamous cell carcinoma. A retrospective clinicopathologic analysis was undertaken of 97 patients with esophageal squamous cell carcinoma who recovered from esophagectomy. Immunohistochemical expression of five histone modification markers, acetylated histone 3 lysine 18 (H3K18Ac), acetylated histone 4 lysine 12 (H4K12Ac), dimethylated histone 4 arginine 3 (H4R3diMe), dimethylated histone 3 lysine 4 (H3 K4diMe), and trimethylated histone 3 lysine 27 (H3K27triMe) was assessed in paraffin-embedded tumor samples. Results were analyzed in relation to patients' clinicopathologic parameters. There was a positive relationship between tumor differentiation and H3K18Ac (P

Original language	English
Pages (from-to)	252-260
Number of pages	9
Journal	Modern Pathology
Volume	22
Issue number	2
DOIs	https://doi.org/10.1038/modpathol.2008.172
Publication status	Published - Feb 2009
Externally published	Yes

Keywords

Esophageal squamous cell carcinoma
Histone modification
Prognosis

ASJC Scopus subject areas

Pathology and Forensic Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/modpathol.2008.172

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abstract = "Patterns of global histone modifications have been recently suggested as outcome predictors in cancer patients. To date, there has been no report on the prognostic significance of global histone modifications in esophageal squamous cell carcinoma. We investigated the role of global histone modification as outcome predictor in patients undergoing esophagectomy for esophageal squamous cell carcinoma. A retrospective clinicopathologic analysis was undertaken of 97 patients with esophageal squamous cell carcinoma who recovered from esophagectomy. Immunohistochemical expression of five histone modification markers, acetylated histone 3 lysine 18 (H3K18Ac), acetylated histone 4 lysine 12 (H4K12Ac), dimethylated histone 4 arginine 3 (H4R3diMe), dimethylated histone 3 lysine 4 (H3 K4diMe), and trimethylated histone 3 lysine 27 (H3K27triMe) was assessed in paraffin-embedded tumor samples. Results were analyzed in relation to patients' clinicopathologic parameters. There was a positive relationship between tumor differentiation and H3K18Ac (P",

keywords = "Esophageal squamous cell carcinoma, Histone modification, Prognosis",

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AU - Sun, Guang Huan

AU - Hsu, Han Shui

AU - Chen, Ban H.

AU - Yu, Cheng Ping

AU - Lee, Shih Chun

PY - 2009/2

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AB - Patterns of global histone modifications have been recently suggested as outcome predictors in cancer patients. To date, there has been no report on the prognostic significance of global histone modifications in esophageal squamous cell carcinoma. We investigated the role of global histone modification as outcome predictor in patients undergoing esophagectomy for esophageal squamous cell carcinoma. A retrospective clinicopathologic analysis was undertaken of 97 patients with esophageal squamous cell carcinoma who recovered from esophagectomy. Immunohistochemical expression of five histone modification markers, acetylated histone 3 lysine 18 (H3K18Ac), acetylated histone 4 lysine 12 (H4K12Ac), dimethylated histone 4 arginine 3 (H4R3diMe), dimethylated histone 3 lysine 4 (H3 K4diMe), and trimethylated histone 3 lysine 27 (H3K27triMe) was assessed in paraffin-embedded tumor samples. Results were analyzed in relation to patients' clinicopathologic parameters. There was a positive relationship between tumor differentiation and H3K18Ac (P

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KW - Histone modification

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Prognostic significance of global histone modifications in resected squamous cell carcinoma of the esophagus

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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