Prognostic significance of global histone modifications in resected squamous cell carcinoma of the esophagus

Ching Tzao, Ho J. Tung, Jong Shiaw Jin, Guang Huan Sun, Han Shui Hsu, Ban H. Chen, Cheng Ping Yu, Shih Chun Lee

Research output: Contribution to journalArticlepeer-review

97 Citations (Scopus)


Patterns of global histone modifications have been recently suggested as outcome predictors in cancer patients. To date, there has been no report on the prognostic significance of global histone modifications in esophageal squamous cell carcinoma. We investigated the role of global histone modification as outcome predictor in patients undergoing esophagectomy for esophageal squamous cell carcinoma. A retrospective clinicopathologic analysis was undertaken of 97 patients with esophageal squamous cell carcinoma who recovered from esophagectomy. Immunohistochemical expression of five histone modification markers, acetylated histone 3 lysine 18 (H3K18Ac), acetylated histone 4 lysine 12 (H4K12Ac), dimethylated histone 4 arginine 3 (H4R3diMe), dimethylated histone 3 lysine 4 (H3 K4diMe), and trimethylated histone 3 lysine 27 (H3K27triMe) was assessed in paraffin-embedded tumor samples. Results were analyzed in relation to patients' clinicopathologic parameters. There was a positive relationship between tumor differentiation and H3K18Ac (P

Original languageEnglish
Pages (from-to)252-260
Number of pages9
JournalModern Pathology
Issue number2
Publication statusPublished - Feb 2009
Externally publishedYes


  • Esophageal squamous cell carcinoma
  • Histone modification
  • Prognosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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