Prognostic significance of DSG3 in rectal adenocarcinoma treated with preoperative chemoradiotherapy

Tung Bo Chao; Chien Feng Li; Ching Yih Lin; Yu Feng Tian; I. Wei Chang; Ming Jen Sheu; Ying En Lee; Ti Chun Chan; Hong Lin He

doi:10.2217/fon-2016-0071

Prognostic significance of DSG3 in rectal adenocarcinoma treated with preoperative chemoradiotherapy

Tung Bo Chao, Chien Feng Li, Ching Yih Lin, Yu Feng Tian, I. Wei Chang, Ming Jen Sheu, Ying En Lee, Ti Chun Chan, Hong Lin He

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Aim: This study aimed to investigate the prognostic significance of DSG3 and its association with response to neoadjuvant concurrent chemoradiotherapy (CCRT) in rectal cancer. Materials & methods: Data mining of a publicly available dataset was performed to find genes associated with CCRT response. Immunohistochemistry was applied to evaluate DSG3 expression. The relationships between DSG3 expression and various clinicopathological parameters and survival were analyzed. Results: The DSG3 gene was significantly associated with CCRT response. The expression of DSG3 negatively correlated with poorer tumor regression (p < 0.001) and had an independent negative impact on disease-specific survival (p = 0.011), local recurrence-free survival (p = 0.031) and metastasis-free survival (p = 0.029). Conclusion: DSG3 was a key prognostic factor and predictor for CCRT response in rectal cancer patients.

Original language	English
Pages (from-to)	1457-1467
Number of pages	11
Journal	Future Oncology
Volume	12
Issue number	12
DOIs	https://doi.org/10.2217/fon-2016-0071
Publication status	Published - Jun 1 2016
Externally published	Yes

Keywords

chemoradiotherapy
DSG3
rectal cancer

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/fon-2016-0071

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@article{1cfc275a19b9467cb7b805b27e220449,

title = "Prognostic significance of DSG3 in rectal adenocarcinoma treated with preoperative chemoradiotherapy",

abstract = "Aim: This study aimed to investigate the prognostic significance of DSG3 and its association with response to neoadjuvant concurrent chemoradiotherapy (CCRT) in rectal cancer. Materials & methods: Data mining of a publicly available dataset was performed to find genes associated with CCRT response. Immunohistochemistry was applied to evaluate DSG3 expression. The relationships between DSG3 expression and various clinicopathological parameters and survival were analyzed. Results: The DSG3 gene was significantly associated with CCRT response. The expression of DSG3 negatively correlated with poorer tumor regression (p < 0.001) and had an independent negative impact on disease-specific survival (p = 0.011), local recurrence-free survival (p = 0.031) and metastasis-free survival (p = 0.029). Conclusion: DSG3 was a key prognostic factor and predictor for CCRT response in rectal cancer patients.",

keywords = "chemoradiotherapy, DSG3, rectal cancer",

author = "Chao, {Tung Bo} and Li, {Chien Feng} and Lin, {Ching Yih} and Tian, {Yu Feng} and Chang, {I. Wei} and Sheu, {Ming Jen} and Lee, {Ying En} and Chan, {Ti Chun} and He, {Hong Lin}",

note = "Publisher Copyright: {\textcopyright} 2016 Future Medicine Ltd.",

year = "2016",

month = jun,

day = "1",

doi = "10.2217/fon-2016-0071",

language = "English",

volume = "12",

pages = "1457--1467",

journal = "Future Oncology",

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TY - JOUR

T1 - Prognostic significance of DSG3 in rectal adenocarcinoma treated with preoperative chemoradiotherapy

AU - Chao, Tung Bo

AU - Li, Chien Feng

AU - Lin, Ching Yih

AU - Tian, Yu Feng

AU - Chang, I. Wei

AU - Sheu, Ming Jen

AU - Lee, Ying En

AU - Chan, Ti Chun

AU - He, Hong Lin

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Aim: This study aimed to investigate the prognostic significance of DSG3 and its association with response to neoadjuvant concurrent chemoradiotherapy (CCRT) in rectal cancer. Materials & methods: Data mining of a publicly available dataset was performed to find genes associated with CCRT response. Immunohistochemistry was applied to evaluate DSG3 expression. The relationships between DSG3 expression and various clinicopathological parameters and survival were analyzed. Results: The DSG3 gene was significantly associated with CCRT response. The expression of DSG3 negatively correlated with poorer tumor regression (p < 0.001) and had an independent negative impact on disease-specific survival (p = 0.011), local recurrence-free survival (p = 0.031) and metastasis-free survival (p = 0.029). Conclusion: DSG3 was a key prognostic factor and predictor for CCRT response in rectal cancer patients.

AB - Aim: This study aimed to investigate the prognostic significance of DSG3 and its association with response to neoadjuvant concurrent chemoradiotherapy (CCRT) in rectal cancer. Materials & methods: Data mining of a publicly available dataset was performed to find genes associated with CCRT response. Immunohistochemistry was applied to evaluate DSG3 expression. The relationships between DSG3 expression and various clinicopathological parameters and survival were analyzed. Results: The DSG3 gene was significantly associated with CCRT response. The expression of DSG3 negatively correlated with poorer tumor regression (p < 0.001) and had an independent negative impact on disease-specific survival (p = 0.011), local recurrence-free survival (p = 0.031) and metastasis-free survival (p = 0.029). Conclusion: DSG3 was a key prognostic factor and predictor for CCRT response in rectal cancer patients.

KW - chemoradiotherapy

KW - DSG3

KW - rectal cancer

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JO - Future Oncology

JF - Future Oncology

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ER -

Prognostic significance of DSG3 in rectal adenocarcinoma treated with preoperative chemoradiotherapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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