TY - JOUR
T1 - Prognostic importance of serial cytokine changes in ascites and pleural effusion in women with severe ovarian hyperstimulation syndrome
AU - Chen, Chin Der
AU - Wu, Ming Yih
AU - Chen, Hsin Fu
AU - Chen, Shee Uan
AU - Ho, Hong Nerng
AU - Yang, Yu Shih
N1 - Funding Information:
Supported by grant DOH88-HR-841 from the Department of Health, the Executive Yuan, and from the National Health Research Institute of the Republic of China.
PY - 1999/8/1
Y1 - 1999/8/1
N2 - Objective: To determine the prognostic value of various cytokine levels in ascites and pleural effusion during the evolution of severe ovarian hyperstimulation syndrome (OHSS). Design: A longitudinal study. Setting: University teaching hospital. Patient(s): Twenty patients with severe OHSS who required either paracentesis or thoracentesis or both from whom ascites (n = 56) or pleural effusion (n = 12) samples were obtained. Control peritoneal fluid was obtained from 20 patients undergoing ovarian stimulation for IVF. Intervention(s): Abdominal paracentesis for tense ascites and thoracentesis for massive pleural effusion. Control peritoneal fluid was obtained before oocyte retrieval. Main Outcome Measure(s): Levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), vascular endothelial growth factor (VEGF), E2, and progesterone concentrations in ascites and pleural effusion. Result(s): Levels of VEGF and IL-6 in ascites dropped significantly during the course of OHSS and were not correlated with E2 concentrations. Levels of VEGF were significantly correlated with levels of IL-1β, IL-8, and TNF-α, as well as progesterone concentrations, hematocrit, and white blood cell counts. None of the cytokine levels measured in pleural effusion were correlated with the course of OHSS. Conclusion(s): These results suggest that local cytokines might be involved in the evolution of severe OHSS and possibly serve as prognostic markers for this syndrome.
AB - Objective: To determine the prognostic value of various cytokine levels in ascites and pleural effusion during the evolution of severe ovarian hyperstimulation syndrome (OHSS). Design: A longitudinal study. Setting: University teaching hospital. Patient(s): Twenty patients with severe OHSS who required either paracentesis or thoracentesis or both from whom ascites (n = 56) or pleural effusion (n = 12) samples were obtained. Control peritoneal fluid was obtained from 20 patients undergoing ovarian stimulation for IVF. Intervention(s): Abdominal paracentesis for tense ascites and thoracentesis for massive pleural effusion. Control peritoneal fluid was obtained before oocyte retrieval. Main Outcome Measure(s): Levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), vascular endothelial growth factor (VEGF), E2, and progesterone concentrations in ascites and pleural effusion. Result(s): Levels of VEGF and IL-6 in ascites dropped significantly during the course of OHSS and were not correlated with E2 concentrations. Levels of VEGF were significantly correlated with levels of IL-1β, IL-8, and TNF-α, as well as progesterone concentrations, hematocrit, and white blood cell counts. None of the cytokine levels measured in pleural effusion were correlated with the course of OHSS. Conclusion(s): These results suggest that local cytokines might be involved in the evolution of severe OHSS and possibly serve as prognostic markers for this syndrome.
KW - Ascites
KW - Cytokines
KW - Ovarian hyperstimulation syndrome
KW - Pleural effusion
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U2 - 10.1016/S0015-0282(99)00206-X
DO - 10.1016/S0015-0282(99)00206-X
M3 - Article
C2 - 10438997
AN - SCOPUS:0033180039
SN - 0015-0282
VL - 72
SP - 286
EP - 292
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 2
ER -