Prognostic factors in adult patients with solid cancers and bone marrow metastases

Yu Shin Hung, Wen Chi Chou, Tai Di Chen, Tse Ching Chen, Po Nan Wang, Hung Chang, Hung Chih Hsu, Wen Chi Shen, Wei Hong Cheng, Jen Shi Chen

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Background: Solid cancers with bone marrow metastases are rare but lethal. This study aimed to identify clinical factors predictive of survival in adult patients with solid cancers and bone marrow metastases. Methods: A total of 83 patients were enrolled consecutively between January 1, 2000 and December 31, 2012. Bone marrow metastases were confirmed by biopsies. Patient clinical features and laboratory data were analyzed for associations. Results: The median age of the patients was 54 years (range, 23-88 years), and 58% were male. The 3 most common primary tumor locations were the stomach (32 patients, 39%), prostate (16 patients, 19%), and lungs (12 patients, 15%). The median overall survival was 49 days (range, 3-1423 days). Patients with Eastern Cooperative Oncology Group performance status 1, cancers of prostate origin, platelet counts over 50,000/ml, and undergoing antitumor therapies had a significantly better prognosis in the multivariate analysis. The median survival times were 173 and 33 days for patients with 2-3 more favorable parameters (n=24) and those with 0-1 (n=69), respectively (hazard ratio 0.30; 95% CI 0.17-0.52, p<0.001). Conclusions: Solid cancers with bone marrow metastases are dismal and incurable diseases. Understanding prognostic factors to these diseases helps medical personnel to provide appropriate treatments and better inform patients about outcomes. Antitumor therapies may improve outcomes in selected patient cohorts.

Original languageEnglish
Pages (from-to)61-67
Number of pages7
JournalAsian Pacific Journal of Cancer Prevention
Issue number1
Publication statusPublished - Jan 1 2014


  • Antitumor therapy
  • Bone marrow metastasis
  • Prognosis
  • Solid cancer

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research


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