Prognostic factors and antibiotics in Vibrio vulnificus septicemia

Jien Wei Liu, Ing Kit Lee, Hung Jen Tang, Wen Chien Ko, Hsin Chun Lee, Yung-Ching Liu, Po Ren Hsueh, Yin Ching Chuang

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83 Citations (Scopus)


Background: Immunocompromised patients with Vibrio vulnificus septicemia are at high risk for fatality. When a hemorrhagic bullous necrotic cutaneous lesion (HBNCL) and decreased blood pressure develop, approximately 50% of V vulnificus septicemic patients die within 48 hours. This study aimed to evaluate the risk factor(s) for fatality among patients with V vulnificus septicemia, emphasizing the role of prescribed antimicrobial agents in general and the therapeutic efficacy of the combination of a third-generation cephalosporin and tetracycline or its analogue in particular. Methods: Patients with the diagnosis of V vulnificus infection admitted to 5 large medical centers in Taiwan between 1995 and 2003 were included in this retrospective study. Patients were divided into 2 groups: those with HBNCLs and those without HBNCLs. Patients were further divided into subgoups without fatalities (fatal subgroup) and those without fatalities (nonfatal subgroup). Results: A total of 93 patients participated in the study. In group 1, the fatal subgroup had higher Acute Physiology and Chronic Health Evaluation II (APACHE II) scores (P=.006) and a higher proportion of shock at arrival at the medical center (P=.015) than the nonfatal subgroup. In group 2, the effect of a first- or secondgeneration cephalosporin plus an aminoglycoside was negative (P = .01) and that of combined third-generation cephalosporin and tetracycline or its analogue was positive (P

Original languageEnglish
Pages (from-to)2117-2123
Number of pages7
JournalArchives of Internal Medicine
Issue number19
Publication statusPublished - Oct 23 2006
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine


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