Progesterone Signaling and Uterine Fibroid Pathogenesis; Molecular Mechanisms and Potential Therapeutics

Mohamed Ali, Michał Ciebiera, Somayeh Vafaei, Samar Alkhrait, Hsin Yuan Chen, Yi Fen Chiang, Ko Chieh Huang, Stepan Feduniw, Shih Min Hsia, Ayman Al-Hendy

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)


Uterine fibroids (UFs) are the most important benign neoplastic threat to women’s health worldwide, with a prevalence of up to 80% in premenopausal women, and can cause heavy menstrual bleeding, pain, and infertility. Progesterone signaling plays a crucial role in the development and growth of UFs. Progesterone promotes the proliferation of UF cells by activating several signaling pathways genetically and epigenetically. In this review article, we reviewed the literature covering progesterone signaling in UF pathogenesis and further discussed the therapeutic potential of compounds that modulate progesterone signaling against UFs, including selective progesterone receptor modulator (SPRM) drugs and natural compounds. Further studies are needed to confirm the safety of SPRMs as well as their exact molecular mechanisms. The consumption of natural compounds as a potential anti-UFs treatment seems promising, since these compounds can be used on a long-term basis—especially for women pursuing concurrent pregnancy, unlike SPRMs. However, further clinical trials are needed to confirm their effectiveness.

Original languageEnglish
Article number1117
Issue number8
Publication statusPublished - Apr 2023


  • leiomyoma
  • natural compounds
  • progesterone
  • SPRM
  • ulipristal
  • uterine fibroids

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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