Proarrhythmic effects of ibutilide in a canine model of pacing induced cardiomyopathy

Ming Hsiung Hsieh; Yi Jen Chen; Shih Huang Lee; Yu An Ding; Mau Song Chang; Shih Ann Chen

doi:10.1111/j.1540-8159.2000.tb00795.x

Proarrhythmic effects of ibutilide in a canine model of pacing induced cardiomyopathy

Ming Hsiung Hsieh, Yi Jen Chen, Shih Huang Lee, Yu An Ding, Mau Song Chang, Shih Ann Chen

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The authors developed a canine model of pacing induced cardiomyopathy to study the possible mechanisms of ibutilide induced torsades de pointes (TP) in heart failure. Thirteen dogs received intravenous ibutilide after acute AV block for 60 minutes, and after implantation of a VVI pacemaker, with a rate of 270 beats/min for 2-3 weeks. Twelve-lead ECG and right and left ventricle monophasic action potentials were recorded at different right ventricle pacing cycle lengths from 600 ms to 1200 ms during the study. The results showed ibutilide could significantly prolong ventricular repolarization and increase the dispersion in a dose dependent and reverse use dependent manner. Furthermore, after ibutilide administration, cardiomyopathic dogs had a greater dispersion of ventricular repolarization, and also had higher incidences of early after depolarizations and spontaneous or pacing induced TP than acute AV block dogs.

Original language	English
Pages (from-to)	149-156
Number of pages	8
Journal	PACE - Pacing and Clinical Electrophysiology
Volume	23
Issue number	2
DOIs	https://doi.org/10.1111/j.1540-8159.2000.tb00795.x
Publication status	Published - 2000

Keywords

Antiarrhythmic drugs
Cardiomyopathy
Torsades de pointes

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1111/j.1540-8159.2000.tb00795.x

Cite this

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title = "Proarrhythmic effects of ibutilide in a canine model of pacing induced cardiomyopathy",

abstract = "The authors developed a canine model of pacing induced cardiomyopathy to study the possible mechanisms of ibutilide induced torsades de pointes (TP) in heart failure. Thirteen dogs received intravenous ibutilide after acute AV block for 60 minutes, and after implantation of a VVI pacemaker, with a rate of 270 beats/min for 2-3 weeks. Twelve-lead ECG and right and left ventricle monophasic action potentials were recorded at different right ventricle pacing cycle lengths from 600 ms to 1200 ms during the study. The results showed ibutilide could significantly prolong ventricular repolarization and increase the dispersion in a dose dependent and reverse use dependent manner. Furthermore, after ibutilide administration, cardiomyopathic dogs had a greater dispersion of ventricular repolarization, and also had higher incidences of early after depolarizations and spontaneous or pacing induced TP than acute AV block dogs.",

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AU - Lee, Shih Huang

AU - Ding, Yu An

AU - Chang, Mau Song

AU - Chen, Shih Ann

PY - 2000

Y1 - 2000

N2 - The authors developed a canine model of pacing induced cardiomyopathy to study the possible mechanisms of ibutilide induced torsades de pointes (TP) in heart failure. Thirteen dogs received intravenous ibutilide after acute AV block for 60 minutes, and after implantation of a VVI pacemaker, with a rate of 270 beats/min for 2-3 weeks. Twelve-lead ECG and right and left ventricle monophasic action potentials were recorded at different right ventricle pacing cycle lengths from 600 ms to 1200 ms during the study. The results showed ibutilide could significantly prolong ventricular repolarization and increase the dispersion in a dose dependent and reverse use dependent manner. Furthermore, after ibutilide administration, cardiomyopathic dogs had a greater dispersion of ventricular repolarization, and also had higher incidences of early after depolarizations and spontaneous or pacing induced TP than acute AV block dogs.

AB - The authors developed a canine model of pacing induced cardiomyopathy to study the possible mechanisms of ibutilide induced torsades de pointes (TP) in heart failure. Thirteen dogs received intravenous ibutilide after acute AV block for 60 minutes, and after implantation of a VVI pacemaker, with a rate of 270 beats/min for 2-3 weeks. Twelve-lead ECG and right and left ventricle monophasic action potentials were recorded at different right ventricle pacing cycle lengths from 600 ms to 1200 ms during the study. The results showed ibutilide could significantly prolong ventricular repolarization and increase the dispersion in a dose dependent and reverse use dependent manner. Furthermore, after ibutilide administration, cardiomyopathic dogs had a greater dispersion of ventricular repolarization, and also had higher incidences of early after depolarizations and spontaneous or pacing induced TP than acute AV block dogs.

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KW - Torsades de pointes

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Proarrhythmic effects of ibutilide in a canine model of pacing induced cardiomyopathy

Abstract

Keywords

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