Primary Cutaneous Peripheral T-Cell Lymphoma with Follicular Helper T-Cell Phenotype: Report of 2 Epstein-Barr Virus-Positive Cases

Chien Ta Chiang; Shih Sung Chuang; Hsuen Fu Lin; Wei Hsuan Li; Ying Yi Chiang; Bo Jung Chen

doi:10.1097/DAD.0000000000002254

Primary Cutaneous Peripheral T-Cell Lymphoma with Follicular Helper T-Cell Phenotype: Report of 2 Epstein-Barr Virus-Positive Cases

Chien Ta Chiang, Shih Sung Chuang, Hsuen Fu Lin, Wei Hsuan Li, Ying Yi Chiang, Bo Jung Chen

Research output: Contribution to journal › Article › peer-review

Abstract

Primary cutaneous T-cell lymphoma is distinct from nodal T-cell lymphoma clinically and pathologically. Recently, primary cutaneous follicular helper T-cell lymphoma (PC-TFHL) has been described as a peripheral T-cell lymphoma with T-follicular helper (TFH) cell phenotype. PC-TFHL usually presents as multiple plaques and nodules of skin with an indolent clinical course, but without association with Epstein-Barr virus. In this article, we report 2 rare cases of PC-TFHL which are Epstein-Barr virus-positive and with an aggressive clinical course. We discuss the challenges in the differential diagnoses, particularly with primary cutaneous extranodal NK/T-cell lymphoma, and nodal T-cell lymphoma of TFH origin with secondary cutaneous involvement.

Original language	English
Pages (from-to)	73-80
Number of pages	8
Journal	American Journal of Dermatopathology
Volume	45
Issue number	2
DOIs	https://doi.org/10.1097/DAD.0000000000002254
Publication status	Published - Feb 1 2023

Keywords

EBV
peripheral T-cell lymphoma
primary cutaneous T-cell lymphoma
TFH

ASJC Scopus subject areas

Pathology and Forensic Medicine
Dermatology

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10.1097/DAD.0000000000002254

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title = "Primary Cutaneous Peripheral T-Cell Lymphoma with Follicular Helper T-Cell Phenotype: Report of 2 Epstein-Barr Virus-Positive Cases",

abstract = "Primary cutaneous T-cell lymphoma is distinct from nodal T-cell lymphoma clinically and pathologically. Recently, primary cutaneous follicular helper T-cell lymphoma (PC-TFHL) has been described as a peripheral T-cell lymphoma with T-follicular helper (TFH) cell phenotype. PC-TFHL usually presents as multiple plaques and nodules of skin with an indolent clinical course, but without association with Epstein-Barr virus. In this article, we report 2 rare cases of PC-TFHL which are Epstein-Barr virus-positive and with an aggressive clinical course. We discuss the challenges in the differential diagnoses, particularly with primary cutaneous extranodal NK/T-cell lymphoma, and nodal T-cell lymphoma of TFH origin with secondary cutaneous involvement.",

keywords = "EBV, peripheral T-cell lymphoma, primary cutaneous T-cell lymphoma, TFH",

author = "Chiang, {Chien Ta} and Chuang, {Shih Sung} and Lin, {Hsuen Fu} and Li, {Wei Hsuan} and Chiang, {Ying Yi} and Chen, {Bo Jung}",

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doi = "10.1097/DAD.0000000000002254",

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T1 - Primary Cutaneous Peripheral T-Cell Lymphoma with Follicular Helper T-Cell Phenotype

T2 - Report of 2 Epstein-Barr Virus-Positive Cases

AU - Chiang, Chien Ta

AU - Chuang, Shih Sung

AU - Lin, Hsuen Fu

AU - Li, Wei Hsuan

AU - Chiang, Ying Yi

AU - Chen, Bo Jung

N1 - Publisher Copyright: © Author(s) (or their employer(s)) 2023.

PY - 2023/2/1

Y1 - 2023/2/1

N2 - Primary cutaneous T-cell lymphoma is distinct from nodal T-cell lymphoma clinically and pathologically. Recently, primary cutaneous follicular helper T-cell lymphoma (PC-TFHL) has been described as a peripheral T-cell lymphoma with T-follicular helper (TFH) cell phenotype. PC-TFHL usually presents as multiple plaques and nodules of skin with an indolent clinical course, but without association with Epstein-Barr virus. In this article, we report 2 rare cases of PC-TFHL which are Epstein-Barr virus-positive and with an aggressive clinical course. We discuss the challenges in the differential diagnoses, particularly with primary cutaneous extranodal NK/T-cell lymphoma, and nodal T-cell lymphoma of TFH origin with secondary cutaneous involvement.

AB - Primary cutaneous T-cell lymphoma is distinct from nodal T-cell lymphoma clinically and pathologically. Recently, primary cutaneous follicular helper T-cell lymphoma (PC-TFHL) has been described as a peripheral T-cell lymphoma with T-follicular helper (TFH) cell phenotype. PC-TFHL usually presents as multiple plaques and nodules of skin with an indolent clinical course, but without association with Epstein-Barr virus. In this article, we report 2 rare cases of PC-TFHL which are Epstein-Barr virus-positive and with an aggressive clinical course. We discuss the challenges in the differential diagnoses, particularly with primary cutaneous extranodal NK/T-cell lymphoma, and nodal T-cell lymphoma of TFH origin with secondary cutaneous involvement.

KW - EBV

KW - peripheral T-cell lymphoma

KW - primary cutaneous T-cell lymphoma

KW - TFH

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Primary Cutaneous Peripheral T-Cell Lymphoma with Follicular Helper T-Cell Phenotype: Report of 2 Epstein-Barr Virus-Positive Cases

Abstract

Keywords

ASJC Scopus subject areas

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