Primary cerebellar extramedullary myeloid cell tumor mimicking oligodendroglioma

Donald Ming Tak Ho, Tai Tong Wong, Wan Yuo Guo, Kai Ping Chang, Sang-Hue Yen

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Extramedullary myeloid cell tumors (EMCTs) are tumors consisting of immature cells of the myeloid series that occur outside the bone marrow. Most of them are associated with acute myelogenous leukemia or other myeloproliferative disorders, and a small number occur as primary lesions, i.e., are not associated with hematological disorders. Occurrence inside the cranium is rare, and there has been only one case of primary EMCT involving the cerebellum reported in the literature. The case we report here is a blastic EMCT occurring in the cerebellum of a 3-year-old boy who had no signs of leukemia or any hematological disorder throughout the entire course. The cerebellar tumor was at first misdiagnosed as an 'oligodendroglioma' because of the uniformity and 'fried egg' artifact of the tumor cells. The tumor disappeared during chemotherapy consisting of 12 treatments. However, it recurred and metastasized to the cerebrospinal fluid (CSF) shortly after the therapy was completed. A diagnosis of EMCT was suspected because of the presence of immature myeloid cells in the CSF, and was confirmed by antimyeloperoxidase and anti-lysozyme immunoreactivity of the cerebellar tumor. The patient succumbed 1 year and 3 months after the first presentation of the disease.

Original languageEnglish
Pages (from-to)398-402
Number of pages5
JournalActa Neuropathologica
Issue number4
Publication statusPublished - Oct 1997
Externally publishedYes


  • Cerebellum
  • Chloroma
  • Extramedullary myeloid cell tumor
  • Granulocytic sarcoma
  • Oligodendroglioma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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