Preventive effects of monascus on androgen-related diseases: Androgenetic alopecia, benign prostatic hyperplasia, and prostate cancer

Hui Wen Chiu; Mei Huei Chen; Wen Hung Fang; Ching Ming Hung; Yen Lin Chen; Ming Der Wu; Gwo Fang Yuan; Ming Jiuan Wu; Ying Jan Wang

doi:10.1021/jf400873w

Preventive effects of monascus on androgen-related diseases: Androgenetic alopecia, benign prostatic hyperplasia, and prostate cancer

Hui Wen Chiu, Mei Huei Chen, Wen Hung Fang, Ching Ming Hung, Yen Lin Chen, Ming Der Wu, Gwo Fang Yuan, Ming Jiuan Wu, Ying Jan Wang

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Androgen-related diseases impair the well-being of many aging men. Unfortunately, the medications used to treat these diseases have many side effects. Therefore, there is a significant need for the development of novel drugs to treat androgen-related diseases. In this study, we investigated the effects of Monascus cursory extraction (M-CE) on androgen-related diseases, including androgenetic alopecia (AGA), benign prostatic hyperplasia (BPH) and prostate cancer. We found that M-CE suppressed baldness in male B6CBAF1/j mice. Furthermore, M-CE decreased PSA levels, indicating a protective effect of M-CE on testosterone-induced hyperplasia. M-CE also significantly decreased tumor volume and tumor incidence in an N-methyl-N-nitrosourea (MNU)/testosterone- induced rat prostate cancer model and markedly decreased dihydrotestosterone (DHT) but not testosterone. Additionally, PCNA expression was decreased in the prostate of rats treated with M-CE. These results suggest that M-CE could be a new potential therapeutic candidate for the treatment of androgen-related diseases.

Original language	English
Pages (from-to)	4379-4386
Number of pages	8
Journal	Journal of Agricultural and Food Chemistry
Volume	61
Issue number	18
DOIs	https://doi.org/10.1021/jf400873w
Publication status	Published - May 8 2013
Externally published	Yes

Keywords

Monascus
androgenetic alopecia
benign prostate hyperplasia
prostate cancer

ASJC Scopus subject areas

General Chemistry
General Agricultural and Biological Sciences

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/jf400873w

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title = "Preventive effects of monascus on androgen-related diseases: Androgenetic alopecia, benign prostatic hyperplasia, and prostate cancer",

abstract = "Androgen-related diseases impair the well-being of many aging men. Unfortunately, the medications used to treat these diseases have many side effects. Therefore, there is a significant need for the development of novel drugs to treat androgen-related diseases. In this study, we investigated the effects of Monascus cursory extraction (M-CE) on androgen-related diseases, including androgenetic alopecia (AGA), benign prostatic hyperplasia (BPH) and prostate cancer. We found that M-CE suppressed baldness in male B6CBAF1/j mice. Furthermore, M-CE decreased PSA levels, indicating a protective effect of M-CE on testosterone-induced hyperplasia. M-CE also significantly decreased tumor volume and tumor incidence in an N-methyl-N-nitrosourea (MNU)/testosterone- induced rat prostate cancer model and markedly decreased dihydrotestosterone (DHT) but not testosterone. Additionally, PCNA expression was decreased in the prostate of rats treated with M-CE. These results suggest that M-CE could be a new potential therapeutic candidate for the treatment of androgen-related diseases.",

keywords = "Monascus, androgenetic alopecia, benign prostate hyperplasia, prostate cancer",

author = "Chiu, {Hui Wen} and Chen, {Mei Huei} and Fang, {Wen Hung} and Hung, {Ching Ming} and Chen, {Yen Lin} and Wu, {Ming Der} and Yuan, {Gwo Fang} and Wu, {Ming Jiuan} and Wang, {Ying Jan}",

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doi = "10.1021/jf400873w",

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T2 - Androgenetic alopecia, benign prostatic hyperplasia, and prostate cancer

AU - Chiu, Hui Wen

AU - Chen, Mei Huei

AU - Fang, Wen Hung

AU - Hung, Ching Ming

AU - Chen, Yen Lin

AU - Wu, Ming Der

AU - Yuan, Gwo Fang

AU - Wu, Ming Jiuan

AU - Wang, Ying Jan

PY - 2013/5/8

Y1 - 2013/5/8

N2 - Androgen-related diseases impair the well-being of many aging men. Unfortunately, the medications used to treat these diseases have many side effects. Therefore, there is a significant need for the development of novel drugs to treat androgen-related diseases. In this study, we investigated the effects of Monascus cursory extraction (M-CE) on androgen-related diseases, including androgenetic alopecia (AGA), benign prostatic hyperplasia (BPH) and prostate cancer. We found that M-CE suppressed baldness in male B6CBAF1/j mice. Furthermore, M-CE decreased PSA levels, indicating a protective effect of M-CE on testosterone-induced hyperplasia. M-CE also significantly decreased tumor volume and tumor incidence in an N-methyl-N-nitrosourea (MNU)/testosterone- induced rat prostate cancer model and markedly decreased dihydrotestosterone (DHT) but not testosterone. Additionally, PCNA expression was decreased in the prostate of rats treated with M-CE. These results suggest that M-CE could be a new potential therapeutic candidate for the treatment of androgen-related diseases.

AB - Androgen-related diseases impair the well-being of many aging men. Unfortunately, the medications used to treat these diseases have many side effects. Therefore, there is a significant need for the development of novel drugs to treat androgen-related diseases. In this study, we investigated the effects of Monascus cursory extraction (M-CE) on androgen-related diseases, including androgenetic alopecia (AGA), benign prostatic hyperplasia (BPH) and prostate cancer. We found that M-CE suppressed baldness in male B6CBAF1/j mice. Furthermore, M-CE decreased PSA levels, indicating a protective effect of M-CE on testosterone-induced hyperplasia. M-CE also significantly decreased tumor volume and tumor incidence in an N-methyl-N-nitrosourea (MNU)/testosterone- induced rat prostate cancer model and markedly decreased dihydrotestosterone (DHT) but not testosterone. Additionally, PCNA expression was decreased in the prostate of rats treated with M-CE. These results suggest that M-CE could be a new potential therapeutic candidate for the treatment of androgen-related diseases.

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KW - benign prostate hyperplasia

KW - prostate cancer

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Preventive effects of monascus on androgen-related diseases: Androgenetic alopecia, benign prostatic hyperplasia, and prostate cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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