TY - JOUR
T1 - Preventing prolonged post-operative ileus in gastric cancer patients undergoing gastrectomy and intra-peritoneal chemotherapy
AU - Chan, De-Chuan
AU - Liu, Yao-Chi
AU - Chen, Cheng-Jueng
AU - Yu, Jyh-Cherng
AU - Chu, Heng-Cheng
AU - Chen, Fa-Chang
AU - Chen, Teng-Wei
AU - Hsieh, Huan-Fa
AU - Chang, Tzu-Ming
AU - Shen, Kuo-Liang
N1 - 被引用次數：12
Export Date: 22 March 2016
CODEN: WJGAF
通訊地址: Chan, D.-C.; Division of General Surgery, National Defense Medical Center, National Defense University, Taipei 114, Taiwan; 電子郵件： [email protected]
化學物質/CAS: atropine, 51-55-8, 55-48-1; bupivacaine, 18010-40-7, 2180-92-9, 55750-21-5; C reactive protein, 9007-41-4; cisatracurium, 96946-41-7, 96946-42-8; desflurane, 57041-67-5; edrophonium, 312-48-1; fentanyl, 437-38-7; lidocaine, 137-58-6, 24847-67-4, 56934-02-2, 73-78-9; metoclopramide, 12707-59-4, 2576-84-3, 364-62-5, 7232-21-5; morphine, 52-26-6, 57-27-2; opiate, 53663-61-9, 8002-76-4, 8008-60-4; paracetamol, 103-90-2; pethidine, 28097-96-3, 50-13-5, 57-42-1; suxamethonium, 306-40-1, 71-27-2; thiamylal, 337-47-3, 77-27-0; Dopamine Antagonists; Electrolytes; Metoclopramide, 364-62-5
參考文獻: Akoh, J.A., Macintyre, I.M., Improving survival in gastric cancer: Review of 5-year survival rates in English language publications from 1970 (1992) Br. J. Surg., 79, pp. 293-299; Landry, J., Tepper, J.E., Wood, W.C., Moulton, E.O., Koerner, F., Sullinger, J., Patterns of failure following curative resection of gastric carcinoma (1990) Int. J. Radiat. Oncol. Biol. Phys., 19, pp. 1357-1362; Hermans, J., Bonenkamp, J.J., Boon, M.C., Bunt, A.M., Ohyama, S., Sasako, M., Van de Velde, C.J., Adjuvant therapy after curative resection for gastric cancer: Meta-analysis of randomized trials (1993) J. Clin. Oncol., 11, pp. 1441-1447; Hallisay, M.T., Dunn, J.A., Ward, L.C., Allum, W.H., The second British stomach cancer group trial of adjuvant radiotherapy or chemotherapy in resectable gastric cancer: Five-year follow-up (1994) Lancet, 343, pp. 1309-1312; Hall, J.J., Loggie, B.W., Shen, P., Beamer, S., Douglas Case, L., McQuellon, R., Geisinger, K.R., Levine, E.A., Cytoreductive surgery with intra-peritoneal hyperthermic chemotherapy for advanced gastric cancer (2004) J. Gastrointest. Surg., 8, pp. 454-463; Sugarbaker, P.H., Yu, W., Yonemura, Y., Gastrectomy, peritonectomy, and perioperative intra-peritoneal chemotherapy: The evolution of treatment strategies for advanced gastric cancer (2003) Semin. Surg. Oncol., 21, pp. 233-248; Sarnaik, A.A., Sussman, J.J., Ahmad, S.A., Lowy, A.M., Technology of intra-peritoneal chemotherapy administration: A survey of techniques with a review of morbidity and mortality (2003) Surg. Oncol. Clin. N. Am., 12, pp. 849-863; Rossi, C.R., Pilati, P., Mocellin, S., Foletto, M., Ori, C., Innocente, F., Nitti, D., Lise, M., Hyperthermic intra-peritoneal intracoperative chemotherapy for peritoneal carcinomatosis arising from gastric adenocarcinoma (2003) Suppl. Tumori, 2, pp. S54-S57; Fujiwara, Y., Taniguchi, H., Kimura, Y., Takiguchi, S., Yasuda, T., Yano, M., Monden, M., Two advanced gastric cancer patients who showed malignant ileus soon after administration of combination therapy of preoperative intra-peritoneal chemotherapy and gastrectomy (2003) Gan To Kagaku Ryoho, 30, pp. 1614-1617; Livingston, E.H., Passaro Jr., E.P., Postoperative ileus (1990) Dig. Dis. Sci., 35, pp. 121-132; Holte, K., Kehlet, H., Postoperative ileus: A preventable event (2000) Br. J. Surg., 87, pp. 1480-1493; Jenner, P., Marsden, C.D., The substituted benzamides - A novel class of dopamine antagonists (1979) Life Sci., 25, pp. 479-485; Albibi, R., McCallum, R.W., Metoclopramide: Pharmacology and clinical application (1983) Ann. Intern. Med., 98, pp. 86-95; Beani, L., Bianchi, C., Cremer, C., Effects of metoclopramide on isolated guinea pig colon. 1. Peripheral sensitization to acetylcholine (1970) Eur. J. Pharmacol., 12, pp. 220-231; Bonacini, M., Quiason, S., Reynolds, M., Gaddis, M., Pemberton, B., Smith, O., Effect of intravenous erythromycin on post-operative ileus (1993) Am. J. Gastroenterol., 88, pp. 208-211; Heimbach, D.M., Crout, J.R., Treatment of paralytic ileus with adrenergic neuronal blocking drugs (1971) Surgery, 69, pp. 582-587; Furness, J.B., Costa, M., Adynamic ileus, its pathogenesis and treatment (1974) Med. Biol., 52, pp. 82-89; Kreis, M.E., Kasparek, M., Zittel, T.T., Becker, H.D., Jehle, E.C., Neostigmine increases post-operative colonic motility in patients undergoing colorectal surgery (2001) Surgery, 130, pp. 449-456; Jepsen, S., Klaerke, A., Nielsen, P.H., Simonsen, O., Negative effect of Metoclopramide in post-operative adynamic ileus. A prospective, randomized, double blind study (1986) Br. J. Surg., 73, pp. 290-291; Maruyama, K., Okabayashi, K., Kinoshita, T., Progress in gastric cancer surgery in Japan and its limits of radicality (1987) World J. Surg., 11, pp. 418-425; Gastric cancer (1998) Japanese Classification of Gastric Carcinoma, pp. 10-24. , Japanese Gastric Cancer Association. 2nd English ed; Sano, T., Sasako, M., Katai, H., Maruyama, K., Amylase concentration of drainage fluid after total gastrectomy (1997) Br. J. Surg., 84, pp. 1310-1312; Zanon, C., Clara, R., Chiappino, I., Bortolini, M., Cornaglia, S., Simone, P., Bruno, F., Pedani, F., Cytoreductive surgery and intra-peritoneal chemohyperthermia for recurrent peritoneal carcinomatosis from ovarian cancer (2004) World J. Surg., 28, pp. 1040-1045; Yano, M., Yasuda, T., Fujiwara, Y., Takiguchi, S., Miyata, H., Monden, M., Preoperative intra-peritoneal chemotherapy for patients with serosa-infiltrating gastric cancer (2004) Surg. Oncol., 88, pp. 39-43; van der Vange, N., van Goethem, A.R., Zoetmulder, F.A., Kaag, M.M., van de Vaart, P.J., ten Bokkel Huinink, W.W., Beijnen, J.H., Extensive cytoreductive surgery combined with intra-operative intra-peritoneal perfusion with cisplatin under hyperthermic conditions (OVHIPEC) in patients with recurrent ovarian cancer: A feasibility pilot (2000) Eur. J. Surg. Onco., 26, pp. 663-668; Gilly, F.N., Beaujard, A., Glehen, O., Grandclement, E., Caillot, J.L., Francois, Y., Sadeghi-Looyeh, B., Vignal, J., Peritonectomy combined with intra-peritoneal chemohyperthermia in abdominal cancer with peritoneal carcinomatosis: Phase I-II study (1999) Anticancer Res., 19, pp. 2317-2321; Bauer, A.J., Boeckxstaens, G.E., Mechanisms of post-operative ileus (2004) Neurogastroenterol. Motil., 16 (SUPPL. 2), pp. 54-60; Luckey, A., Livingston, E., Tache, Y., Mechanisms and treatment of post-operative ileus (2003) Arch. Surg., 138, pp. 206-214; Barquist, E., Bonaz, B., Martinez, V., Rivier, J., Zinner, M.J., Tache, Y., Neuronal pathways involved in abdominal surgery-induced gastric ileus in rats (1996) Am. J. Physiol., 270, pp. R888-R894; Tache, Y., Monnikes, H., Bonaz, B., Rivier, J., Role of CRF in stress-related alterations of gastric and colonic motor function (1993) Ann. N. Y. Acad. Sci., 697, pp. 233-243; Kalff, J.C., Schraut, W.H., Simmons, R.L., Bauer, A.J., Surgical manipulation of the gut elicits an intestinal muscularis inflammatory response resulting in postsurgical ileus (1998) Ann. Surg., 228, pp. 652-663; Kalff, J.C., Buchholz, B.M., Eskandari, M.K., Hierholzer, C., Schraut, W.H., Simmons, R.L., Bauer, A.J., Biphasic response to gut manipulation and temporal correlation of cellular infiltrates and muscle dysfunction in rat (1999) Surgery, 126, pp. 498-509; Kalff, J.C., Carlos, T.M., Schraut, W.H., Billiar, T.R., Simmons, R.L., Bauer, A.J., Surgically induced leukocytic infiltrates within the rat intestinal muscularis mediate post-operative ileus (1999) Gastroenterology, 117, pp. 378-387; Cannon, W., Murphy, F., The movements of the stomach and intestines in some surgical conditions (1906) Ann. Surg., 43, pp. 512-536; Prasad, M., Matthews, J., Deflating post-operative ileus (1999) Gastroenterology, 117, pp. 489-492; Dou, Y., Gregersen, S., Zhao, J., Zhuang, F., Gregersen, H., Morphometric and biomechanical intestinal remodeling induced by fasting in rats (2002) Dig. Dis. Sci., 47, pp. 1158-1168; Baue, A.E., The role of the gut in the development of multiple organ dysfunction in cardiothoracic patients (1993) Ann. Thorac. Surg., 55, pp. 822-829; Deitch, E.A., Berg, R., Bacterial translocation from the gut: A mechanism of infection (1987) J. Burn Care Rehabil., 8, pp. 475-482; Jooste, C.A., Mustoe, J., Collee, G., Metoclopramide improves gastric motility in critically ill patients (1999) Intensive Care Med., 25, pp. 464-468; MacLaren, R., Intolerance to intragastric enteral nutrition in critically ill patients: Complications and management (2000) Pharmacotherapy, 20, pp. 1486-1498; Liu, S., Carpenter, R.L., Neal, J.M., Epidural anesthesia and analgesia (1995) Anesthesiology, 82, pp. 1474-1506; Carpenter, R.L., Gastrointestinal benefits of regional anesthesia/analgesia (1996) Reg. Anesth., 21, pp. 13-17; Steinbrook, R.A., Epidural anesthesia and gastrointestinal motility (1998) Anesth. Analg., 86, pp. 837-844; Garcia-Olmo, D., Paya, J., Lucas, F.J., Garcia-Olmo, D.C., The effects of the pharmacological manipulation of post-operative intestinal motility on colonic anastomoses. An experimental study in a rat model (1997) Int. J. Colorectal Dis., 12, pp. 73-77; Jansen, M., Fass, J., Tittel, A., Mumme, T., Anurov, M., Titkova, S., Polivoda, M., Schumpelick, V., Influence of post-operative epidural analgesia with bupivacaine on intestinal motility, transit time, and anastomotic healing (2002) World J. Surg., 26, pp. 303-306; Holte, K., Kehlet, H., Epidural analgesia and risk of anastomotic leakage (2001) Reg. Anesth. Pain Med., 26, pp. 111-117; Fotiadis, R.J., Badvie, S., Weston, M.D., Allen-Mersh, T.G., Epidural analgesia in gastrointestinal surgery (2004) Br. J. Surg., 91, pp. 828-841; Chung, H.Y., Yu, W., Reevaluation of routine gastrointestinal decompression after gastrectomy for gastric cancer (2003) Hepatogastroenterology, 50, pp. 1190-1192; Yoo, C.H., Son, B.H., Han, W.K., Pae, W.K., Nasogastric decompression is not necessary in operations for gastric cancer: Prospective randomised trial (2002) Eur. J. Surg., 168, pp. 379-383
PY - 2005
Y1 - 2005
N2 - Aim: To assess the efficacy of metoclopramide (Met) for prevention of prolonged post-operative ileus in advanced gastric cancer patients undergoing D2 gastrectomy and intra-peritoneal chemotherapy (IPC). Methods: Thirty-two advanced gastric cancer patients undergoing D2 gastrectomy and IPC were allocated to two groups. Sixteen patients received Met immediately after operation (group A), and 16 did not (group B). Another 16 patients who underwent D2 gastrectomy without IPC were enrolled as the control group (group C). All patients had received epidural pain control. The primary endpoints were time to first post-operative flatus and time until oral feeding with a soft diet without discomfort. Secondary endpoints were early complications during hospitalization. Results: Gender, the type of resection, operating time, blood loss, tumor status and amount of narcotics were comparable in the three groups. However, the group C patients were older than those in groups A and B (67.5±17.7 vs 56.8±13.2, 57.5±11.7 years, P = 0.048). First bowel flatus occurred after 4.35±0.93 d in group A, 4.94±1.37 d in group B, and 4.71±1.22 d in group C (P>0.05). Oral feeding of a soft diet was tolerated 7.21±1.92 d after operation in group A, 10.15±2.17 d in group B, and 7.53±1.35 d in group C (groups A and C vs group B, P
AB - Aim: To assess the efficacy of metoclopramide (Met) for prevention of prolonged post-operative ileus in advanced gastric cancer patients undergoing D2 gastrectomy and intra-peritoneal chemotherapy (IPC). Methods: Thirty-two advanced gastric cancer patients undergoing D2 gastrectomy and IPC were allocated to two groups. Sixteen patients received Met immediately after operation (group A), and 16 did not (group B). Another 16 patients who underwent D2 gastrectomy without IPC were enrolled as the control group (group C). All patients had received epidural pain control. The primary endpoints were time to first post-operative flatus and time until oral feeding with a soft diet without discomfort. Secondary endpoints were early complications during hospitalization. Results: Gender, the type of resection, operating time, blood loss, tumor status and amount of narcotics were comparable in the three groups. However, the group C patients were older than those in groups A and B (67.5±17.7 vs 56.8±13.2, 57.5±11.7 years, P = 0.048). First bowel flatus occurred after 4.35±0.93 d in group A, 4.94±1.37 d in group B, and 4.71±1.22 d in group C (P>0.05). Oral feeding of a soft diet was tolerated 7.21±1.92 d after operation in group A, 10.15±2.17 d in group B, and 7.53±1.35 d in group C (groups A and C vs group B, P
KW - C-reactive protein
KW - Gastric cancer
KW - Intraperitoneal chemotherapy
KW - Metoclopramide
KW - antineoplastic agent
KW - atropine
KW - bupivacaine
KW - C reactive protein
KW - cisatracurium
KW - desflurane
KW - edrophonium
KW - fentanyl
KW - lidocaine
KW - metoclopramide
KW - morphine
KW - narcotic agent
KW - opiate
KW - paracetamol
KW - pethidine
KW - suxamethonium
KW - thiamylal
KW - adult
KW - aged
KW - anastomosis leakage
KW - article
KW - bleeding
KW - cancer chemotherapy
KW - chronic disease
KW - clinical article
KW - clinical trial
KW - controlled clinical trial
KW - controlled study
KW - drug dose regimen
KW - drug efficacy
KW - drug mechanism
KW - drug use
KW - epidural anesthesia
KW - feeding
KW - female
KW - flatulence
KW - gastrectomy
KW - gender
KW - hospitalization
KW - human
KW - ileus
KW - incidence
KW - male
KW - mortality
KW - operation duration
KW - outcomes research
KW - pneumonia
KW - postoperative care
KW - postoperative complication
KW - postoperative pain
KW - prophylaxis
KW - risk assessment
KW - stomach cancer
KW - surgical technique
KW - wound infection
KW - Adult
KW - Aged
KW - Dopamine Antagonists
KW - Electrolytes
KW - Female
KW - Gastrectomy
KW - Humans
KW - Ileus
KW - Male
KW - Middle Aged
KW - Pain, Postoperative
KW - Postoperative Complications
KW - Stomach Neoplasms
M3 - Article
SN - 1007-9327
VL - 11
SP - 4776
EP - 4781
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
IS - 31
ER -
