Preventing prolonged post-operative ileus in gastric cancer patients undergoing gastrectomy and intra-peritoneal chemotherapy

De-Chuan Chan, Yao-Chi Liu, Cheng-Jueng Chen, Jyh-Cherng Yu, Heng-Cheng Chu, Fa-Chang Chen, Teng-Wei Chen, Huan-Fa Hsieh, Tzu-Ming Chang, Kuo-Liang Shen

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16 Citations (Scopus)


Aim: To assess the efficacy of metoclopramide (Met) for prevention of prolonged post-operative ileus in advanced gastric cancer patients undergoing D2 gastrectomy and intra-peritoneal chemotherapy (IPC). Methods: Thirty-two advanced gastric cancer patients undergoing D2 gastrectomy and IPC were allocated to two groups. Sixteen patients received Met immediately after operation (group A), and 16 did not (group B). Another 16 patients who underwent D2 gastrectomy without IPC were enrolled as the control group (group C). All patients had received epidural pain control. The primary endpoints were time to first post-operative flatus and time until oral feeding with a soft diet without discomfort. Secondary endpoints were early complications during hospitalization. Results: Gender, the type of resection, operating time, blood loss, tumor status and amount of narcotics were comparable in the three groups. However, the group C patients were older than those in groups A and B (67.5±17.7 vs 56.8±13.2, 57.5±11.7 years, P = 0.048). First bowel flatus occurred after 4.35±0.93 d in group A, 4.94±1.37 d in group B, and 4.71±1.22 d in group C (P>0.05). Oral feeding of a soft diet was tolerated 7.21±1.92 d after operation in group A, 10.15±2.17 d in group B, and 7.53±1.35 d in group C (groups A and C vs group B, P
Original languageEnglish
Pages (from-to)4776-4781
Number of pages6
JournalWorld Journal of Gastroenterology
Issue number31
Publication statusPublished - 2005
Externally publishedYes


  • C-reactive protein
  • Gastric cancer
  • Intraperitoneal chemotherapy
  • Metoclopramide
  • antineoplastic agent
  • atropine
  • bupivacaine
  • C reactive protein
  • cisatracurium
  • desflurane
  • edrophonium
  • fentanyl
  • lidocaine
  • metoclopramide
  • morphine
  • narcotic agent
  • opiate
  • paracetamol
  • pethidine
  • suxamethonium
  • thiamylal
  • adult
  • aged
  • anastomosis leakage
  • article
  • bleeding
  • cancer chemotherapy
  • chronic disease
  • clinical article
  • clinical trial
  • controlled clinical trial
  • controlled study
  • drug dose regimen
  • drug efficacy
  • drug mechanism
  • drug use
  • epidural anesthesia
  • feeding
  • female
  • flatulence
  • gastrectomy
  • gender
  • hospitalization
  • human
  • ileus
  • incidence
  • male
  • mortality
  • operation duration
  • outcomes research
  • pneumonia
  • postoperative care
  • postoperative complication
  • postoperative pain
  • prophylaxis
  • risk assessment
  • stomach cancer
  • surgical technique
  • wound infection
  • Adult
  • Aged
  • Dopamine Antagonists
  • Electrolytes
  • Female
  • Gastrectomy
  • Humans
  • Ileus
  • Male
  • Middle Aged
  • Pain, Postoperative
  • Postoperative Complications
  • Stomach Neoplasms


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