TY - JOUR
T1 - Prevalence of insulin resistance and determination of risk factors for glucose intolerance in polycystic ovary syndrome
T2 - a cross-sectional study of Chinese infertility patients
AU - Wei, Hsiao Jui
AU - Young, Robert
AU - Kuo, I. Li
AU - Liaw, Chian Mey
AU - Chiang, Han-Sun
AU - Yeh, Ching Ying
PY - 2009/5
Y1 - 2009/5
N2 - Objective: To determine the prevalence of abnormalities in glucose metabolism in patients with polycystic ovary syndrome (PCOS) and control infertility patients in Taiwan, and to determine the predictive risk factors for PCOS. Design: Cross-sectional study. Setting: Infertility Center, Taiwan Adventist Hospital. Patient(s): Three hundred fifty-six patients with PCOS and 974 control infertility patients. Intervention(s): None. Main Outcomes Measure(s): Hormone assay and 75-g oral glucose tolerance test. Result(s): Patients with PCOS were younger (32.7 vs. 35.3 years) with a higher body mass index (BMI) (22.4 vs. 20.6 kg/m2) than controls. Even after BMI adjustment, patients with PCOS still had significantly higher fasting glucose (97.2 vs. 94.4 mg/dL), fasting insulin (5.6 vs. 4.1 μIU/mL), 2-hour glucose (108.1 vs. 96.0 mg/dL), and 2-hour insulin levels (38.0 vs. 27.0 μIU/mL), and higher homeostasis model assessment of insulin resistance (HOMA-IR) values (1.3 vs. 1.0) than control patients. The prevalence of impaired glucose tolerance and diabetes mellitus in patients with PCOS was 7.6% and 3.1%, respectively, compared with 2.9% and 0.2% in the control group, respectively. Only fasting glucose and insulin, 2-hour insulin, HOMA-IR, age, androstenedione, and status (PCOS vs. control) had a significant impact on 2-hour glucose level. However, BMI and waist/hip ratio did not show a significant impact on 2-hour glucose level. Conclusion(s): Chinese women with PCOS are at increased risk for insulin resistance and glucose intolerance compared with controls. Body mass index failed to show significant impact on 2-hour glucose levels in our infertility patients.
AB - Objective: To determine the prevalence of abnormalities in glucose metabolism in patients with polycystic ovary syndrome (PCOS) and control infertility patients in Taiwan, and to determine the predictive risk factors for PCOS. Design: Cross-sectional study. Setting: Infertility Center, Taiwan Adventist Hospital. Patient(s): Three hundred fifty-six patients with PCOS and 974 control infertility patients. Intervention(s): None. Main Outcomes Measure(s): Hormone assay and 75-g oral glucose tolerance test. Result(s): Patients with PCOS were younger (32.7 vs. 35.3 years) with a higher body mass index (BMI) (22.4 vs. 20.6 kg/m2) than controls. Even after BMI adjustment, patients with PCOS still had significantly higher fasting glucose (97.2 vs. 94.4 mg/dL), fasting insulin (5.6 vs. 4.1 μIU/mL), 2-hour glucose (108.1 vs. 96.0 mg/dL), and 2-hour insulin levels (38.0 vs. 27.0 μIU/mL), and higher homeostasis model assessment of insulin resistance (HOMA-IR) values (1.3 vs. 1.0) than control patients. The prevalence of impaired glucose tolerance and diabetes mellitus in patients with PCOS was 7.6% and 3.1%, respectively, compared with 2.9% and 0.2% in the control group, respectively. Only fasting glucose and insulin, 2-hour insulin, HOMA-IR, age, androstenedione, and status (PCOS vs. control) had a significant impact on 2-hour glucose level. However, BMI and waist/hip ratio did not show a significant impact on 2-hour glucose level. Conclusion(s): Chinese women with PCOS are at increased risk for insulin resistance and glucose intolerance compared with controls. Body mass index failed to show significant impact on 2-hour glucose levels in our infertility patients.
KW - Chinese infertility patients
KW - glucose intolerance
KW - insulin resistance
KW - OGTT
KW - risk factors
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U2 - 10.1016/j.fertnstert.2008.02.168
DO - 10.1016/j.fertnstert.2008.02.168
M3 - Article
C2 - 18565519
AN - SCOPUS:67349278300
SN - 0015-0282
VL - 91
SP - 1864
EP - 1868
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 5
ER -