Prevalence and risk factors for age-related macular degeneration in the elderly Chinese population in south-western Taiwan: the Puzih eye study

Evelyn Jou Chen Huang, S-H Wu, C-H Lai, C-N Kuo, P-C Wu, C-L Chen, C-Y Chen, Y-C King, P-C Wu

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38 Citations (Scopus)

Abstract

AIM: This study aimed to ascertain the prevalence of and the risk factors associated with early and late age-related macular degeneration (AMD) among Chinese individuals aged ≥65 years residing in Puzih, Taiwan.

METHODS: This population-based cross-sectional study graded digital colour photographs of the ocular fundus of 673 individuals using the Wisconsin Age-Related Maculopathy Grading System. We compared the characteristics of individuals with early and late AMD using χ(2)-analyses and described risk factors for early and late AMD using odds ratios and 95% confidence intervals.

RESULTS: Individuals with late AMD were significantly older and more likely to have hypertension. Further, their sunlight exposure time was longer than that of those with early AMD, only drusen, or no AMD lesions (P<0.01). A history of hyperlipidaemia for >10 years was a significant risk factor for early AMD, while old age, hypertension for >10 years, and exposure to sunlight for >8 h per day were associated with late AMD.

CONCLUSIONS: The prevalence rate of early AMD in the present study was 15.0%, which is similar to that reported for Caucasians and Japanese included in the European Eye Study and the Hisayama Study, respectively. The late AMD prevalence rate of 7.3% found among our study participants was comparable to that reported by the Greenland Inuit Eye Study and Reykjavik Study, but considerably lower than that reported for Caucasians, indicating that late AMD might be less prevalent among Asians than Caucasians.

Original languageEnglish
Pages (from-to)705-14
Number of pages10
JournalTransactions of the Ophthalmological Societies of the United Kingdom
Volume28
Issue number6
DOIs
Publication statusPublished - Jun 2014
Externally publishedYes

Keywords

  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Asian People/ethnology
  • Cross-Sectional Studies
  • Female
  • Health Surveys
  • Humans
  • Macular Degeneration/classification
  • Male
  • Odds Ratio
  • Photography
  • Prevalence
  • Risk Factors
  • Sex Distribution
  • Taiwan/epidemiology

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