Presence of CSE1L protein in urine of patients with urinary bladder urothelial carcinomas

Cheng Jeng Tai; Ching Fong Liao; Tzu Cheng Su; Ko Hung Shen; Chun Chao Chang; Shu Hui Lin; Chung Min Yeh; Shing Chuan Shen; Woan Ruoh Lee; Jeng Fong Chiou; Chih Hung Lin; Ying Chun Chen; Hsin Yi Shih; Kun Tu Yeh; Ming Chung Jiang

doi:10.5301/JBM.2012.9310

Presence of CSE1L protein in urine of patients with urinary bladder urothelial carcinomas

Cheng Jeng Tai, Ching Fong Liao, Tzu Cheng Su, Ko Hung Shen, Chun Chao Chang, Shu Hui Lin, Chung Min Yeh, Shing Chuan Shen, Woan Ruoh Lee, Jeng Fong Chiou, Chih Hung Lin, Ying Chun Chen, Hsin Yi Shih, Kun Tu Yeh, Ming Chung Jiang

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The chromosome segregation 1-like (CSE1L) protein is highly expressed in most cancers and has been shown to be secreted by tumor cells. We studied the presence of CSE1L in the urine of patients with bladder urothelial carcinomas. The results of our immunohistochemical analysis showed a high expression of CSE1L in bladder cancer specimens, while the normal bladder specimens only showed a very faint staining in some cells. Immunoblotting showed that CSE1L was present in urine of patients with bladder cancer. Urinary CSE1L-positive cases were detected in 95% (57/60) of patients with bladder urothelial carcinomas or the atypical/suspicious cases with urothelial atypia. No CSE1L was detected in urine of healthy controls (p

Original language	English
Pages (from-to)	e280-e284
Journal	International Journal of Biological Markers
Volume	27
Issue number	3
DOIs	https://doi.org/10.5301/JBM.2012.9310
Publication status	Published - Jul 2012

Keywords

Bladder cancer
Tumor markers
Urine
Urothelial carcinomas

ASJC Scopus subject areas

Pathology and Forensic Medicine
Oncology
Clinical Biochemistry
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.5301/JBM.2012.9310

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Tai, C. J., Liao, C. F., Su, T. C., Shen, K. H., Chang, C. C., Lin, S. H., Yeh, C. M., Shen, S. C., Lee, W. R., Chiou, J. F., Lin, C. H., Chen, Y. C., Shih, H. Y., Yeh, K. T., & Jiang, M. C. (2012). Presence of CSE1L protein in urine of patients with urinary bladder urothelial carcinomas. International Journal of Biological Markers, 27(3), e280-e284. https://doi.org/10.5301/JBM.2012.9310

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abstract = "The chromosome segregation 1-like (CSE1L) protein is highly expressed in most cancers and has been shown to be secreted by tumor cells. We studied the presence of CSE1L in the urine of patients with bladder urothelial carcinomas. The results of our immunohistochemical analysis showed a high expression of CSE1L in bladder cancer specimens, while the normal bladder specimens only showed a very faint staining in some cells. Immunoblotting showed that CSE1L was present in urine of patients with bladder cancer. Urinary CSE1L-positive cases were detected in 95% (57/60) of patients with bladder urothelial carcinomas or the atypical/suspicious cases with urothelial atypia. No CSE1L was detected in urine of healthy controls (p",

keywords = "Bladder cancer, Tumor markers, Urine, Urothelial carcinomas",

author = "Tai, {Cheng Jeng} and Liao, {Ching Fong} and Su, {Tzu Cheng} and Shen, {Ko Hung} and Chang, {Chun Chao} and Lin, {Shu Hui} and Yeh, {Chung Min} and Shen, {Shing Chuan} and Lee, {Woan Ruoh} and Chiou, {Jeng Fong} and Lin, {Chih Hung} and Chen, {Ying Chun} and Shih, {Hsin Yi} and Yeh, {Kun Tu} and Jiang, {Ming Chung}",

year = "2012",

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doi = "10.5301/JBM.2012.9310",

language = "English",

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AU - Tai, Cheng Jeng

AU - Liao, Ching Fong

AU - Su, Tzu Cheng

AU - Shen, Ko Hung

AU - Chang, Chun Chao

AU - Lin, Shu Hui

AU - Yeh, Chung Min

AU - Shen, Shing Chuan

AU - Lee, Woan Ruoh

AU - Chiou, Jeng Fong

AU - Lin, Chih Hung

AU - Chen, Ying Chun

AU - Shih, Hsin Yi

AU - Yeh, Kun Tu

AU - Jiang, Ming Chung

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N2 - The chromosome segregation 1-like (CSE1L) protein is highly expressed in most cancers and has been shown to be secreted by tumor cells. We studied the presence of CSE1L in the urine of patients with bladder urothelial carcinomas. The results of our immunohistochemical analysis showed a high expression of CSE1L in bladder cancer specimens, while the normal bladder specimens only showed a very faint staining in some cells. Immunoblotting showed that CSE1L was present in urine of patients with bladder cancer. Urinary CSE1L-positive cases were detected in 95% (57/60) of patients with bladder urothelial carcinomas or the atypical/suspicious cases with urothelial atypia. No CSE1L was detected in urine of healthy controls (p

AB - The chromosome segregation 1-like (CSE1L) protein is highly expressed in most cancers and has been shown to be secreted by tumor cells. We studied the presence of CSE1L in the urine of patients with bladder urothelial carcinomas. The results of our immunohistochemical analysis showed a high expression of CSE1L in bladder cancer specimens, while the normal bladder specimens only showed a very faint staining in some cells. Immunoblotting showed that CSE1L was present in urine of patients with bladder cancer. Urinary CSE1L-positive cases were detected in 95% (57/60) of patients with bladder urothelial carcinomas or the atypical/suspicious cases with urothelial atypia. No CSE1L was detected in urine of healthy controls (p

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KW - Tumor markers

KW - Urine

KW - Urothelial carcinomas

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Presence of CSE1L protein in urine of patients with urinary bladder urothelial carcinomas

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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