Preparation of improved bioactive tissue adhesives using autologous human thrombin

C. Y. Su; T. Burnouf

Preparation of improved bioactive tissue adhesives using autologous human thrombin

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The two types of bioactive tissue adhesives were prepared by using autologous human thrombin. The clotting times as well as the levels of platelet-derived growth factor (PDGF-AB) and transforming growth factor-β1 (TGF-β1) of platelet gels, obtained from PRP mixed with either bovine thrombin (BT) or autologous human thrombin (AHT), were compared. It was suggested that AHT is more potent trigger for granule secretion and growth factors release than BT, and is a suitable agent to activate PRP to prepare 100% autologous bioactive platelet gel. The use of AHT would avoid the immunological and infectious risks potentially associated to BT. AHT can be prepared with the plasma from the same donor using a specially designed reaction device.

Original language	English
Title of host publication	Transactions - 7th World Biomaterials Congress
Pages	1652
Number of pages	1
Publication status	Published - 2004
Externally published	Yes
Event	Transactions - 7th World Biomaterials Congress - Sydney, Australia Duration: May 17 2004 → May 21 2004

Publication series

Name	Transactions - 7th World Biomaterials Congress

Other

Other	Transactions - 7th World Biomaterials Congress
Country/Territory	Australia
City	Sydney
Period	5/17/04 → 5/21/04

ASJC Scopus subject areas

General Engineering

Cite this

@inproceedings{de88f8cd408441eb98c3eeed3d02e412,

title = "Preparation of improved bioactive tissue adhesives using autologous human thrombin",

abstract = "The two types of bioactive tissue adhesives were prepared by using autologous human thrombin. The clotting times as well as the levels of platelet-derived growth factor (PDGF-AB) and transforming growth factor-β1 (TGF-β1) of platelet gels, obtained from PRP mixed with either bovine thrombin (BT) or autologous human thrombin (AHT), were compared. It was suggested that AHT is more potent trigger for granule secretion and growth factors release than BT, and is a suitable agent to activate PRP to prepare 100% autologous bioactive platelet gel. The use of AHT would avoid the immunological and infectious risks potentially associated to BT. AHT can be prepared with the plasma from the same donor using a specially designed reaction device.",

author = "Su, {C. Y.} and T. Burnouf",

year = "2004",

language = "English",

isbn = "1877040193",

series = "Transactions - 7th World Biomaterials Congress",

pages = "1652",

booktitle = "Transactions - 7th World Biomaterials Congress",

note = "Transactions - 7th World Biomaterials Congress ; Conference date: 17-05-2004 Through 21-05-2004",

}

TY - GEN

T1 - Preparation of improved bioactive tissue adhesives using autologous human thrombin

AU - Su, C. Y.

AU - Burnouf, T.

PY - 2004

Y1 - 2004

N2 - The two types of bioactive tissue adhesives were prepared by using autologous human thrombin. The clotting times as well as the levels of platelet-derived growth factor (PDGF-AB) and transforming growth factor-β1 (TGF-β1) of platelet gels, obtained from PRP mixed with either bovine thrombin (BT) or autologous human thrombin (AHT), were compared. It was suggested that AHT is more potent trigger for granule secretion and growth factors release than BT, and is a suitable agent to activate PRP to prepare 100% autologous bioactive platelet gel. The use of AHT would avoid the immunological and infectious risks potentially associated to BT. AHT can be prepared with the plasma from the same donor using a specially designed reaction device.

AB - The two types of bioactive tissue adhesives were prepared by using autologous human thrombin. The clotting times as well as the levels of platelet-derived growth factor (PDGF-AB) and transforming growth factor-β1 (TGF-β1) of platelet gels, obtained from PRP mixed with either bovine thrombin (BT) or autologous human thrombin (AHT), were compared. It was suggested that AHT is more potent trigger for granule secretion and growth factors release than BT, and is a suitable agent to activate PRP to prepare 100% autologous bioactive platelet gel. The use of AHT would avoid the immunological and infectious risks potentially associated to BT. AHT can be prepared with the plasma from the same donor using a specially designed reaction device.

UR - http://www.scopus.com/inward/record.url?scp=13844267102&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13844267102&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:13844267102

SN - 1877040193

SN - 9781877040191

T3 - Transactions - 7th World Biomaterials Congress

SP - 1652

BT - Transactions - 7th World Biomaterials Congress

T2 - Transactions - 7th World Biomaterials Congress

Y2 - 17 May 2004 through 21 May 2004

ER -

Preparation of improved bioactive tissue adhesives using autologous human thrombin

Abstract

Publication series

Other

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this