Preparation of Calcium Phosphate Compounds on Zirconia Surfaces for Dental Implant Applications

Mei Shuan Cheng, Eisner Salamanca, Jerry Chin Yi Lin, Yu Hwa Pan, Yi Fan Wu, Nai Chia Teng, Ikki Watanabe, Ying Sui Sun, Wei Jen Chang

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Titanium is widely used in medical implants despite the release of heavy metal ions over long-term use. Zirconia is very close to the color of teeth; however, its biological inertness hinders bonding with bone tissue. Alkaline treatment and coatings of calcium phosphate can be used to enhance bone regeneration adjacent to dental implants. This study examined the effects of alkaline treatment, calcium phosphate coatings, and sintering, on the physical properties of implant material. Our analysis confirmed that the calcium phosphate species were octacalcium phosphate (OCP). The sintering of calcium phosphate was shown to create B-type HAP, which is highly conducive toward the differentiation of mesenchymal stem cells (MSCs) into osteoblasts for the facilitation of bone integration. Conclusions: This study demonstrated the room-temperature fabrication of dental implants with superhydrophilic surfaces to enhance biocompatibility.

Original languageEnglish
Article number6675
JournalInternational journal of molecular sciences
Issue number12
Publication statusPublished - Jun 1 2022


  • alkali treatment
  • calcium phosphate coating
  • sintering
  • surface modification
  • zirconia

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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