Preparation of Calcium Phosphate Compounds on Zirconia Surfaces for Dental Implant Applications

Mei Shuan Cheng; Eisner Salamanca; Jerry Chin Yi Lin; Yu Hwa Pan; Yi Fan Wu; Nai Chia Teng; Ikki Watanabe; Ying Sui Sun; Wei Jen Chang

doi:10.3390/ijms23126675

Preparation of Calcium Phosphate Compounds on Zirconia Surfaces for Dental Implant Applications

Mei Shuan Cheng, Eisner Salamanca, Jerry Chin Yi Lin, Yu Hwa Pan, Yi Fan Wu, Nai Chia Teng, Ikki Watanabe, Ying Sui Sun, Wei Jen Chang

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Titanium is widely used in medical implants despite the release of heavy metal ions over long-term use. Zirconia is very close to the color of teeth; however, its biological inertness hinders bonding with bone tissue. Alkaline treatment and coatings of calcium phosphate can be used to enhance bone regeneration adjacent to dental implants. This study examined the effects of alkaline treatment, calcium phosphate coatings, and sintering, on the physical properties of implant material. Our analysis confirmed that the calcium phosphate species were octacalcium phosphate (OCP). The sintering of calcium phosphate was shown to create B-type HAP, which is highly conducive toward the differentiation of mesenchymal stem cells (MSCs) into osteoblasts for the facilitation of bone integration. Conclusions: This study demonstrated the room-temperature fabrication of dental implants with superhydrophilic surfaces to enhance biocompatibility.

Original language	English
Article number	6675
Journal	International journal of molecular sciences
Volume	23
Issue number	12
DOIs	https://doi.org/10.3390/ijms23126675
Publication status	Published - Jun 1 2022

Keywords

alkali treatment
calcium phosphate coating
sintering
surface modification
zirconia

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.3390/ijms23126675

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title = "Preparation of Calcium Phosphate Compounds on Zirconia Surfaces for Dental Implant Applications",

abstract = "Titanium is widely used in medical implants despite the release of heavy metal ions over long-term use. Zirconia is very close to the color of teeth; however, its biological inertness hinders bonding with bone tissue. Alkaline treatment and coatings of calcium phosphate can be used to enhance bone regeneration adjacent to dental implants. This study examined the effects of alkaline treatment, calcium phosphate coatings, and sintering, on the physical properties of implant material. Our analysis confirmed that the calcium phosphate species were octacalcium phosphate (OCP). The sintering of calcium phosphate was shown to create B-type HAP, which is highly conducive toward the differentiation of mesenchymal stem cells (MSCs) into osteoblasts for the facilitation of bone integration. Conclusions: This study demonstrated the room-temperature fabrication of dental implants with superhydrophilic surfaces to enhance biocompatibility.",

keywords = "alkali treatment, calcium phosphate coating, sintering, surface modification, zirconia",

author = "Cheng, {Mei Shuan} and Eisner Salamanca and Lin, {Jerry Chin Yi} and Pan, {Yu Hwa} and Wu, {Yi Fan} and Teng, {Nai Chia} and Ikki Watanabe and Sun, {Ying Sui} and Chang, {Wei Jen}",

note = "Funding Information: The authors are grateful to the Ministry of Science and Technology of Taiwan (MOST 107-2321-B-038-007-MY3, MOST 110-2314-B-038-029-and MOST 110-2314-B-038-065-MY3) for their financial support. Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = jun,

day = "1",

doi = "10.3390/ijms23126675",

language = "English",

volume = "23",

journal = "International journal of molecular sciences",

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T1 - Preparation of Calcium Phosphate Compounds on Zirconia Surfaces for Dental Implant Applications

AU - Cheng, Mei Shuan

AU - Salamanca, Eisner

AU - Lin, Jerry Chin Yi

AU - Pan, Yu Hwa

AU - Wu, Yi Fan

AU - Teng, Nai Chia

AU - Watanabe, Ikki

AU - Sun, Ying Sui

AU - Chang, Wei Jen

N1 - Funding Information: The authors are grateful to the Ministry of Science and Technology of Taiwan (MOST 107-2321-B-038-007-MY3, MOST 110-2314-B-038-029-and MOST 110-2314-B-038-065-MY3) for their financial support. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/6/1

Y1 - 2022/6/1

N2 - Titanium is widely used in medical implants despite the release of heavy metal ions over long-term use. Zirconia is very close to the color of teeth; however, its biological inertness hinders bonding with bone tissue. Alkaline treatment and coatings of calcium phosphate can be used to enhance bone regeneration adjacent to dental implants. This study examined the effects of alkaline treatment, calcium phosphate coatings, and sintering, on the physical properties of implant material. Our analysis confirmed that the calcium phosphate species were octacalcium phosphate (OCP). The sintering of calcium phosphate was shown to create B-type HAP, which is highly conducive toward the differentiation of mesenchymal stem cells (MSCs) into osteoblasts for the facilitation of bone integration. Conclusions: This study demonstrated the room-temperature fabrication of dental implants with superhydrophilic surfaces to enhance biocompatibility.

AB - Titanium is widely used in medical implants despite the release of heavy metal ions over long-term use. Zirconia is very close to the color of teeth; however, its biological inertness hinders bonding with bone tissue. Alkaline treatment and coatings of calcium phosphate can be used to enhance bone regeneration adjacent to dental implants. This study examined the effects of alkaline treatment, calcium phosphate coatings, and sintering, on the physical properties of implant material. Our analysis confirmed that the calcium phosphate species were octacalcium phosphate (OCP). The sintering of calcium phosphate was shown to create B-type HAP, which is highly conducive toward the differentiation of mesenchymal stem cells (MSCs) into osteoblasts for the facilitation of bone integration. Conclusions: This study demonstrated the room-temperature fabrication of dental implants with superhydrophilic surfaces to enhance biocompatibility.

KW - alkali treatment

KW - calcium phosphate coating

KW - sintering

KW - surface modification

KW - zirconia

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Preparation of Calcium Phosphate Compounds on Zirconia Surfaces for Dental Implant Applications

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Keywords

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