Preparation of 6-phenyl- and 8-phenyl tetrahydroisoquinolines from boldine

Wei Jan Huang; Chung Hsiung Chen; Shoei Sheng Lee

doi:10.3987/com-03-9764

Preparation of 6-phenyl- and 8-phenyl tetrahydroisoquinolines from boldine

Wei Jan Huang, Chung Hsiung Chen, Shoei Sheng Lee

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Four 6-phenyl- and 8-phenyltetrahydroisoquinolines were prepared by structural modifications of boldine nucleus. These involved four major reaction steps, including solvolysis of 2-hydroxyaporphine, ozonolysis of the C-9, 10 double bond of phenanthrene nucleus leading to the key intermediate, and final Pictet-Spengler cyclization to respective target products.

Original language	English
Pages (from-to)	1573-1588
Number of pages	16
Journal	Heterocycles
Volume	60
Issue number	7
DOIs	https://doi.org/10.3987/com-03-9764
Publication status	Published - Jul 1 2003
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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abstract = "Four 6-phenyl- and 8-phenyltetrahydroisoquinolines were prepared by structural modifications of boldine nucleus. These involved four major reaction steps, including solvolysis of 2-hydroxyaporphine, ozonolysis of the C-9, 10 double bond of phenanthrene nucleus leading to the key intermediate, and final Pictet-Spengler cyclization to respective target products.",

author = "Huang, {Wei Jan} and Chen, {Chung Hsiung} and Lee, {Shoei Sheng}",

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Preparation of 6-phenyl- and 8-phenyl tetrahydroisoquinolines from boldine

Abstract

ASJC Scopus subject areas

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