Preoperative proteinuria predicts adverse renal outcomes after coronary artery bypass grafting

Tao Min Huang, Vin Cent Wu, Guang Huar Young, Yu Feng Lin, Chih Chung Shiao, Pei Chen Wu, Wen Yi Li, Hsi Yu Yu, Fu Chang Hu, Jou Wei Lin, Yih Sharng Chen, Yen Hung Lin, Shoei Shen Wang, Ron Bin Hsu, Fan Chi Chang, Nai Kuan Chou, Tzong Shinn Chu, Yu Chang Yeh, Pi Ru Tsai, Jenq Wen HuangShuei Liong Lin, Yung Ming Chen, Wen Je Ko, Kwan Dun Wu

Research output: Contribution to journalArticlepeer-review

140 Citations (Scopus)


Whether preoperative proteinuria associates with adverse renal outcomes after cardiac surgery is unknown. Here, we performed a secondary analysis of a prospectively enrolled cohort of adult patients undergoing coronary artery bypass grafting (CABG) at a medical center and its two affiliate hospitals between 2003 and 2007. We excluded patients with stage 5 CKD or those who received dialysis previously. We defined proteinuria, measured with a dipstick, as mild (trace to 1+) or heavy (2+ to 4+). Among a total of 1052 patients, cardiac surgery-associated acute kidney injury (CSA-AKI) developed in 183 (17.4%) patients and required renal replacement therapy (RRT) in 50 (4.8%) patients. In a multiple logistic regression model, mild and heavy proteinuria each associated with an increased odds of CSA-AKI, independent of CKD stage and the presence of diabetes mellitus (mild: OR 1.66, 95% CI 1.09 to 2.52; heavy: OR 2.30, 95% CI 1.35 to 3.90). Heavy proteinuria also associated with increased odds of postoperative RRT (OR 7.29, 95% CI 3.00 to 17.73). In summary, these data suggest that preoperative proteinuria is a predictor of CSA-AKI among patients undergoing CABG.

Original languageEnglish
Pages (from-to)156-163
Number of pages8
JournalJournal of the American Society of Nephrology
Issue number1
Publication statusPublished - Jan 2011
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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