Preoperative proteinuria predicts adverse renal outcomes after coronary artery bypass grafting

Tao Min Huang; Vin Cent Wu; Guang Huar Young; Yu Feng Lin; Chih Chung Shiao; Pei Chen Wu; Wen Yi Li; Hsi Yu Yu; Fu Chang Hu; Jou Wei Lin; Yih Sharng Chen; Yen Hung Lin; Shoei Shen Wang; Ron Bin Hsu; Fan Chi Chang; Nai Kuan Chou; Tzong Shinn Chu; Yu Chang Yeh; Pi Ru Tsai; Jenq Wen Huang; Shuei Liong Lin; Yung Ming Chen; Wen Je Ko; Kwan Dun Wu

doi:10.1681/ASN.2010050553

Preoperative proteinuria predicts adverse renal outcomes after coronary artery bypass grafting

Tao Min Huang, Vin Cent Wu, Guang Huar Young, Yu Feng Lin, Chih Chung Shiao, Pei Chen Wu, Wen Yi Li, Hsi Yu Yu, Fu Chang Hu, Jou Wei Lin, Yih Sharng Chen, Yen Hung Lin, Shoei Shen Wang, Ron Bin Hsu, Fan Chi Chang, Nai Kuan Chou, Tzong Shinn Chu, Yu Chang Yeh, Pi Ru Tsai, Jenq Wen HuangShuei Liong Lin, Yung Ming Chen, Wen Je Ko, Kwan Dun Wu

Research output: Contribution to journal › Article › peer-review

132 Citations (Scopus)

Abstract

Whether preoperative proteinuria associates with adverse renal outcomes after cardiac surgery is unknown. Here, we performed a secondary analysis of a prospectively enrolled cohort of adult patients undergoing coronary artery bypass grafting (CABG) at a medical center and its two affiliate hospitals between 2003 and 2007. We excluded patients with stage 5 CKD or those who received dialysis previously. We defined proteinuria, measured with a dipstick, as mild (trace to 1+) or heavy (2+ to 4+). Among a total of 1052 patients, cardiac surgery-associated acute kidney injury (CSA-AKI) developed in 183 (17.4%) patients and required renal replacement therapy (RRT) in 50 (4.8%) patients. In a multiple logistic regression model, mild and heavy proteinuria each associated with an increased odds of CSA-AKI, independent of CKD stage and the presence of diabetes mellitus (mild: OR 1.66, 95% CI 1.09 to 2.52; heavy: OR 2.30, 95% CI 1.35 to 3.90). Heavy proteinuria also associated with increased odds of postoperative RRT (OR 7.29, 95% CI 3.00 to 17.73). In summary, these data suggest that preoperative proteinuria is a predictor of CSA-AKI among patients undergoing CABG.

Original language	English
Pages (from-to)	156-163
Number of pages	8
Journal	Journal of the American Society of Nephrology
Volume	22
Issue number	1
DOIs	https://doi.org/10.1681/ASN.2010050553
Publication status	Published - Jan 2011
Externally published	Yes

ASJC Scopus subject areas

Nephrology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1681/ASN.2010050553

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Huang, T. M., Wu, V. C., Young, G. H., Lin, Y. F., Shiao, C. C., Wu, P. C., Li, W. Y., Yu, H. Y., Hu, F. C., Lin, J. W., Chen, Y. S., Lin, Y. H., Wang, S. S., Hsu, R. B., Chang, F. C., Chou, N. K., Chu, T. S., Yeh, Y. C., Tsai, P. R., ... Wu, K. D. (2011). Preoperative proteinuria predicts adverse renal outcomes after coronary artery bypass grafting. Journal of the American Society of Nephrology, 22(1), 156-163. https://doi.org/10.1681/ASN.2010050553

Huang, TM, Wu, VC, Young, GH, Lin, YF, Shiao, CC, Wu, PC, Li, WY, Yu, HY, Hu, FC, Lin, JW, Chen, YS, Lin, YH, Wang, SS, Hsu, RB, Chang, FC, Chou, NK, Chu, TS, Yeh, YC, Tsai, PR, Huang, JW, Lin, SL, Chen, YM, Ko, WJ & Wu, KD 2011, 'Preoperative proteinuria predicts adverse renal outcomes after coronary artery bypass grafting', Journal of the American Society of Nephrology, vol. 22, no. 1, pp. 156-163. https://doi.org/10.1681/ASN.2010050553

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title = "Preoperative proteinuria predicts adverse renal outcomes after coronary artery bypass grafting",

abstract = "Whether preoperative proteinuria associates with adverse renal outcomes after cardiac surgery is unknown. Here, we performed a secondary analysis of a prospectively enrolled cohort of adult patients undergoing coronary artery bypass grafting (CABG) at a medical center and its two affiliate hospitals between 2003 and 2007. We excluded patients with stage 5 CKD or those who received dialysis previously. We defined proteinuria, measured with a dipstick, as mild (trace to 1+) or heavy (2+ to 4+). Among a total of 1052 patients, cardiac surgery-associated acute kidney injury (CSA-AKI) developed in 183 (17.4%) patients and required renal replacement therapy (RRT) in 50 (4.8%) patients. In a multiple logistic regression model, mild and heavy proteinuria each associated with an increased odds of CSA-AKI, independent of CKD stage and the presence of diabetes mellitus (mild: OR 1.66, 95% CI 1.09 to 2.52; heavy: OR 2.30, 95% CI 1.35 to 3.90). Heavy proteinuria also associated with increased odds of postoperative RRT (OR 7.29, 95% CI 3.00 to 17.73). In summary, these data suggest that preoperative proteinuria is a predictor of CSA-AKI among patients undergoing CABG.",

author = "Huang, {Tao Min} and Wu, {Vin Cent} and Young, {Guang Huar} and Lin, {Yu Feng} and Shiao, {Chih Chung} and Wu, {Pei Chen} and Li, {Wen Yi} and Yu, {Hsi Yu} and Hu, {Fu Chang} and Lin, {Jou Wei} and Chen, {Yih Sharng} and Lin, {Yen Hung} and Wang, {Shoei Shen} and Hsu, {Ron Bin} and Chang, {Fan Chi} and Chou, {Nai Kuan} and Chu, {Tzong Shinn} and Yeh, {Yu Chang} and Tsai, {Pi Ru} and Huang, {Jenq Wen} and Lin, {Shuei Liong} and Chen, {Yung Ming} and Ko, {Wen Je} and Wu, {Kwan Dun}",

year = "2011",

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doi = "10.1681/ASN.2010050553",

language = "English",

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T1 - Preoperative proteinuria predicts adverse renal outcomes after coronary artery bypass grafting

AU - Huang, Tao Min

AU - Wu, Vin Cent

AU - Young, Guang Huar

AU - Lin, Yu Feng

AU - Shiao, Chih Chung

AU - Wu, Pei Chen

AU - Li, Wen Yi

AU - Yu, Hsi Yu

AU - Hu, Fu Chang

AU - Lin, Jou Wei

AU - Chen, Yih Sharng

AU - Lin, Yen Hung

AU - Wang, Shoei Shen

AU - Hsu, Ron Bin

AU - Chang, Fan Chi

AU - Chou, Nai Kuan

AU - Chu, Tzong Shinn

AU - Yeh, Yu Chang

AU - Tsai, Pi Ru

AU - Huang, Jenq Wen

AU - Lin, Shuei Liong

AU - Chen, Yung Ming

AU - Ko, Wen Je

AU - Wu, Kwan Dun

PY - 2011/1

Y1 - 2011/1

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Preoperative proteinuria predicts adverse renal outcomes after coronary artery bypass grafting

Abstract

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