Preoperative ECOG performance status as a predictor of outcomes in upper tract urothelial cancer surgery

Tsung Mu Yang; I. Hsuan Alan Chen; Chia Cheng Yu; Chi Rei Yang; Wen Chi Chen; Po Hung Lin; See Tong Pang; Steven Kuan Hua Huang; Zhi‐Hao Chen; Jen Shu Tseng; Wun Rong Lin; Yao Chou Tsai; Chih Chin Yu; Pi Che Chen; Ian Seng Cheong; Yuan Hong Jiang; Chia Chang Wu; Hsu Che Huang; Ting En Tai; Chung You Tsai; Wei Yu Lin; Yung Tai Chen; Richard Chen Yu Wu; Hsiang Ying Lee; Hsin Chih Yeh

doi:10.1038/s41598-025-95128-1

Preoperative ECOG performance status as a predictor of outcomes in upper tract urothelial cancer surgery

Tsung Mu Yang
, I. Hsuan Alan Chen
, Chia Cheng Yu
, Chi Rei Yang
, Wen Chi Chen
, Po Hung Lin
, See Tong Pang
, Steven Kuan Hua Huang
, Zhi‐Hao Chen
, Jen Shu Tseng
, Wun Rong Lin
, Yao Chou Tsai
, Chih Chin Yu
, Pi Che Chen
, Ian Seng Cheong
, Yuan Hong Jiang
, Chia Chang Wu
, Hsu Che Huang
, Ting En Tai
, Chung You Tsai

Wei Yu Lin, Yung Tai Chen, Richard Chen Yu Wu, Hsiang Ying Lee, Hsin Chih Yeh

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Eastern Cooperative Oncology Group performance status (ECOG-PS) is a widely used functional status measure in oncology, yet its prognostic value in upper tract urothelial carcinoma remains unclear. In this multicenter study of 2473 patients undergoing radical nephroureterectomy, ECOG-PS ≥ 2 was independently associated with worse overall survival (hazard ratio [HR] 2.53, p < 0.001), cancer-specific survival (HR 2.02, p < 0.001), and disease-free survival (HR 1.50, p = 0.003) than those with ECOG-PS 0–1. They also had a higher risk of major perioperative complications (odds ratio 2.46, p < 0.001). These findings support ECOG-PS as a valuable preoperative risk stratification tool.

Original language	English
Article number	10356
Journal	Scientific Reports
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41598-025-95128-1
Publication status	Published - Dec 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Eastern cooperative oncology group
Major perioperative complication
Radical nephroureterectomy
Survival outcome
Upper tract urothelial carcinoma

ASJC Scopus subject areas

General

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10.1038/s41598-025-95128-1

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Yang, T. M., Chen, I. H. A., Yu, C. C., Yang, C. R., Chen, W. C., Lin, P. H., Pang, S. T., Huang, S. K. H., Chen, ZH., Tseng, J. S., Lin, W. R., Tsai, Y. C., Yu, C. C., Chen, P. C., Cheong, I. S., Jiang, Y. H., Wu, C. C., Huang, H. C., Tai, T. E., ... Yeh, H. C. (2025). Preoperative ECOG performance status as a predictor of outcomes in upper tract urothelial cancer surgery. Scientific Reports, 15(1), Article 10356. https://doi.org/10.1038/s41598-025-95128-1

Yang, TM, Chen, IHA, Yu, CC, Yang, CR, Chen, WC, Lin, PH, Pang, ST, Huang, SKH, Chen, ZH, Tseng, JS, Lin, WR, Tsai, YC, Yu, CC, Chen, PC, Cheong, IS, Jiang, YH, Wu, CC, Huang, HC, Tai, TE, Tsai, CY, Lin, WY, Chen, YT, Wu, RCY, Lee, HY & Yeh, HC 2025, 'Preoperative ECOG performance status as a predictor of outcomes in upper tract urothelial cancer surgery', Scientific Reports, vol. 15, no. 1, 10356. https://doi.org/10.1038/s41598-025-95128-1

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title = "Preoperative ECOG performance status as a predictor of outcomes in upper tract urothelial cancer surgery",

abstract = "Eastern Cooperative Oncology Group performance status (ECOG-PS) is a widely used functional status measure in oncology, yet its prognostic value in upper tract urothelial carcinoma remains unclear. In this multicenter study of 2473 patients undergoing radical nephroureterectomy, ECOG-PS ≥ 2 was independently associated with worse overall survival (hazard ratio [HR] 2.53, p < 0.001), cancer-specific survival (HR 2.02, p < 0.001), and disease-free survival (HR 1.50, p = 0.003) than those with ECOG-PS 0{\textendash}1. They also had a higher risk of major perioperative complications (odds ratio 2.46, p < 0.001). These findings support ECOG-PS as a valuable preoperative risk stratification tool.",

keywords = "Eastern cooperative oncology group, Major perioperative complication, Radical nephroureterectomy, Survival outcome, Upper tract urothelial carcinoma",

author = "Yang, \{Tsung Mu\} and Chen, \{I. Hsuan Alan\} and Yu, \{Chia Cheng\} and Yang, \{Chi Rei\} and Chen, \{Wen Chi\} and Lin, \{Po Hung\} and Pang, \{See Tong\} and Huang, \{Steven Kuan Hua\} and Zhi‐Hao Chen and Tseng, \{Jen Shu\} and Lin, \{Wun Rong\} and Tsai, \{Yao Chou\} and Yu, \{Chih Chin\} and Chen, \{Pi Che\} and Cheong, \{Ian Seng\} and Jiang, \{Yuan Hong\} and Wu, \{Chia Chang\} and Huang, \{Hsu Che\} and Tai, \{Ting En\} and Tsai, \{Chung You\} and Lin, \{Wei Yu\} and Chen, \{Yung Tai\} and Wu, \{Richard Chen Yu\} and Lee, \{Hsiang Ying\} and Yeh, \{Hsin Chih\}",

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doi = "10.1038/s41598-025-95128-1",

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AU - Yang, Tsung Mu

AU - Chen, I. Hsuan Alan

AU - Yu, Chia Cheng

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AU - Chen, Wen Chi

AU - Lin, Po Hung

AU - Pang, See Tong

AU - Huang, Steven Kuan Hua

AU - Chen, Zhi‐Hao

AU - Tseng, Jen Shu

AU - Lin, Wun Rong

AU - Tsai, Yao Chou

AU - Yu, Chih Chin

AU - Chen, Pi Che

AU - Cheong, Ian Seng

AU - Jiang, Yuan Hong

AU - Wu, Chia Chang

AU - Huang, Hsu Che

AU - Tai, Ting En

AU - Tsai, Chung You

AU - Lin, Wei Yu

AU - Chen, Yung Tai

AU - Wu, Richard Chen Yu

AU - Lee, Hsiang Ying

AU - Yeh, Hsin Chih

PY - 2025/12

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N2 - Eastern Cooperative Oncology Group performance status (ECOG-PS) is a widely used functional status measure in oncology, yet its prognostic value in upper tract urothelial carcinoma remains unclear. In this multicenter study of 2473 patients undergoing radical nephroureterectomy, ECOG-PS ≥ 2 was independently associated with worse overall survival (hazard ratio [HR] 2.53, p < 0.001), cancer-specific survival (HR 2.02, p < 0.001), and disease-free survival (HR 1.50, p = 0.003) than those with ECOG-PS 0–1. They also had a higher risk of major perioperative complications (odds ratio 2.46, p < 0.001). These findings support ECOG-PS as a valuable preoperative risk stratification tool.

AB - Eastern Cooperative Oncology Group performance status (ECOG-PS) is a widely used functional status measure in oncology, yet its prognostic value in upper tract urothelial carcinoma remains unclear. In this multicenter study of 2473 patients undergoing radical nephroureterectomy, ECOG-PS ≥ 2 was independently associated with worse overall survival (hazard ratio [HR] 2.53, p < 0.001), cancer-specific survival (HR 2.02, p < 0.001), and disease-free survival (HR 1.50, p = 0.003) than those with ECOG-PS 0–1. They also had a higher risk of major perioperative complications (odds ratio 2.46, p < 0.001). These findings support ECOG-PS as a valuable preoperative risk stratification tool.

KW - Eastern cooperative oncology group

KW - Major perioperative complication

KW - Radical nephroureterectomy

KW - Survival outcome

KW - Upper tract urothelial carcinoma

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Preoperative ECOG performance status as a predictor of outcomes in upper tract urothelial cancer surgery

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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