Preoperative ECOG performance status as a predictor of outcomes in upper tract urothelial cancer surgery

Tsung Mu Yang; I. Hsuan Alan Chen; Chia Cheng Yu; Chi Rei Yang; Wen Chi Chen; Po Hung Lin; See Tong Pang; Steven Kuan Hua Huang; Zhi‐Hao Chen; Jen Shu Tseng; Wun Rong Lin; Yao Chou Tsai; Chih Chin Yu; Pi Che Chen; Ian Seng Cheong; Yuan Hong Jiang; Chia Chang Wu; Hsu Che Huang; Ting En Tai; Chung You Tsai; Wei Yu Lin; Yung Tai Chen; Richard Chen Yu Wu; Hsiang Ying Lee; Hsin Chih Yeh

doi:10.1038/s41598-025-95128-1

Preoperative ECOG performance status as a predictor of outcomes in upper tract urothelial cancer surgery

Tsung Mu Yang, I. Hsuan Alan Chen, Chia Cheng Yu, Chi Rei Yang, Wen Chi Chen, Po Hung Lin, See Tong Pang, Steven Kuan Hua Huang, Zhi‐Hao Chen, Jen Shu Tseng, Wun Rong Lin, Yao Chou Tsai, Chih Chin Yu, Pi Che Chen, Ian Seng Cheong, Yuan Hong Jiang, Chia Chang Wu, Hsu Che Huang, Ting En Tai, Chung You TsaiWei Yu Lin, Yung Tai Chen, Richard Chen Yu Wu, Hsiang Ying Lee, Hsin Chih Yeh

Research output: Contribution to journal › Article › peer-review

Abstract

Eastern Cooperative Oncology Group performance status (ECOG-PS) is a widely used functional status measure in oncology, yet its prognostic value in upper tract urothelial carcinoma remains unclear. In this multicenter study of 2473 patients undergoing radical nephroureterectomy, ECOG-PS ≥ 2 was independently associated with worse overall survival (hazard ratio [HR] 2.53, p < 0.001), cancer-specific survival (HR 2.02, p < 0.001), and disease-free survival (HR 1.50, p = 0.003) than those with ECOG-PS 0–1. They also had a higher risk of major perioperative complications (odds ratio 2.46, p < 0.001). These findings support ECOG-PS as a valuable preoperative risk stratification tool.

Original language	English
Article number	10356
Journal	Scientific Reports
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41598-025-95128-1
Publication status	Published - Dec 2025

Keywords

Eastern cooperative oncology group
Major perioperative complication
Radical nephroureterectomy
Survival outcome
Upper tract urothelial carcinoma

ASJC Scopus subject areas

General

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41598-025-95128-1

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Yang, T. M., Chen, I. H. A., Yu, C. C., Yang, C. R., Chen, W. C., Lin, P. H., Pang, S. T., Huang, S. K. H., Chen, ZH., Tseng, J. S., Lin, W. R., Tsai, Y. C., Yu, C. C., Chen, P. C., Cheong, I. S., Jiang, Y. H., Wu, C. C., Huang, H. C., Tai, T. E., ... Yeh, H. C. (2025). Preoperative ECOG performance status as a predictor of outcomes in upper tract urothelial cancer surgery. Scientific Reports, 15(1), Article 10356. https://doi.org/10.1038/s41598-025-95128-1

Yang, TM, Chen, IHA, Yu, CC, Yang, CR, Chen, WC, Lin, PH, Pang, ST, Huang, SKH, Chen, ZH, Tseng, JS, Lin, WR, Tsai, YC, Yu, CC, Chen, PC, Cheong, IS, Jiang, YH, Wu, CC, Huang, HC, Tai, TE, Tsai, CY, Lin, WY, Chen, YT, Wu, RCY, Lee, HY & Yeh, HC 2025, 'Preoperative ECOG performance status as a predictor of outcomes in upper tract urothelial cancer surgery', Scientific Reports, vol. 15, no. 1, 10356. https://doi.org/10.1038/s41598-025-95128-1

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title = "Preoperative ECOG performance status as a predictor of outcomes in upper tract urothelial cancer surgery",

abstract = "Eastern Cooperative Oncology Group performance status (ECOG-PS) is a widely used functional status measure in oncology, yet its prognostic value in upper tract urothelial carcinoma remains unclear. In this multicenter study of 2473 patients undergoing radical nephroureterectomy, ECOG-PS ≥ 2 was independently associated with worse overall survival (hazard ratio [HR] 2.53, p < 0.001), cancer-specific survival (HR 2.02, p < 0.001), and disease-free survival (HR 1.50, p = 0.003) than those with ECOG-PS 0–1. They also had a higher risk of major perioperative complications (odds ratio 2.46, p < 0.001). These findings support ECOG-PS as a valuable preoperative risk stratification tool.",

keywords = "Eastern cooperative oncology group, Major perioperative complication, Radical nephroureterectomy, Survival outcome, Upper tract urothelial carcinoma",

author = "Yang, \{Tsung Mu\} and Chen, \{I. Hsuan Alan\} and Yu, \{Chia Cheng\} and Yang, \{Chi Rei\} and Chen, \{Wen Chi\} and Lin, \{Po Hung\} and Pang, \{See Tong\} and Huang, \{Steven Kuan Hua\} and Zhi‐Hao Chen and Tseng, \{Jen Shu\} and Lin, \{Wun Rong\} and Tsai, \{Yao Chou\} and Yu, \{Chih Chin\} and Chen, \{Pi Che\} and Cheong, \{Ian Seng\} and Jiang, \{Yuan Hong\} and Wu, \{Chia Chang\} and Huang, \{Hsu Che\} and Tai, \{Ting En\} and Tsai, \{Chung You\} and Lin, \{Wei Yu\} and Chen, \{Yung Tai\} and Wu, \{Richard Chen Yu\} and Lee, \{Hsiang Ying\} and Yeh, \{Hsin Chih\}",

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year = "2025",

month = dec,

doi = "10.1038/s41598-025-95128-1",

language = "English",

volume = "15",

journal = "Scientific Reports",

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AU - Yang, Tsung Mu

AU - Chen, I. Hsuan Alan

AU - Yu, Chia Cheng

AU - Yang, Chi Rei

AU - Chen, Wen Chi

AU - Lin, Po Hung

AU - Pang, See Tong

AU - Huang, Steven Kuan Hua

AU - Chen, Zhi‐Hao

AU - Tseng, Jen Shu

AU - Lin, Wun Rong

AU - Tsai, Yao Chou

AU - Yu, Chih Chin

AU - Chen, Pi Che

AU - Cheong, Ian Seng

AU - Jiang, Yuan Hong

AU - Wu, Chia Chang

AU - Huang, Hsu Che

AU - Tai, Ting En

AU - Tsai, Chung You

AU - Lin, Wei Yu

AU - Chen, Yung Tai

AU - Wu, Richard Chen Yu

AU - Lee, Hsiang Ying

AU - Yeh, Hsin Chih

PY - 2025/12

Y1 - 2025/12

N2 - Eastern Cooperative Oncology Group performance status (ECOG-PS) is a widely used functional status measure in oncology, yet its prognostic value in upper tract urothelial carcinoma remains unclear. In this multicenter study of 2473 patients undergoing radical nephroureterectomy, ECOG-PS ≥ 2 was independently associated with worse overall survival (hazard ratio [HR] 2.53, p < 0.001), cancer-specific survival (HR 2.02, p < 0.001), and disease-free survival (HR 1.50, p = 0.003) than those with ECOG-PS 0–1. They also had a higher risk of major perioperative complications (odds ratio 2.46, p < 0.001). These findings support ECOG-PS as a valuable preoperative risk stratification tool.

AB - Eastern Cooperative Oncology Group performance status (ECOG-PS) is a widely used functional status measure in oncology, yet its prognostic value in upper tract urothelial carcinoma remains unclear. In this multicenter study of 2473 patients undergoing radical nephroureterectomy, ECOG-PS ≥ 2 was independently associated with worse overall survival (hazard ratio [HR] 2.53, p < 0.001), cancer-specific survival (HR 2.02, p < 0.001), and disease-free survival (HR 1.50, p = 0.003) than those with ECOG-PS 0–1. They also had a higher risk of major perioperative complications (odds ratio 2.46, p < 0.001). These findings support ECOG-PS as a valuable preoperative risk stratification tool.

KW - Eastern cooperative oncology group

KW - Major perioperative complication

KW - Radical nephroureterectomy

KW - Survival outcome

KW - Upper tract urothelial carcinoma

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Preoperative ECOG performance status as a predictor of outcomes in upper tract urothelial cancer surgery

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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