TY - JOUR
T1 - Pregnancy achieved by intracytoplasmic sperm injection using cryopreserved vasal-epididymal sperm from a man with spinal cord injury
AU - Chen, Shee Uan
AU - Shieh, Jeng Yi
AU - Wang, Yen Ho
AU - Chang, Hong Chiang
AU - Ho, Hong Nerng
AU - Yang, Yu Shih
N1 - Funding Information:
From the Department of Obstetrics and Gynecology (Drs. Chen, Ho, Yang), Department of Physical Medicine and Rehabilitation (Drs. Shieh, Wang), and Department of Urology (Dr. Chang), College of Medicine and the Hospital, National Taiwan University, Taipei, Taiwan. Submitted for publication June 2, 1997. Accepted in revised form July 14, 1998. Supported in part by grants from the National Science Council (NSC-82-412-B002-343), Taipei, Taiwan. No commercia1 party having a direct tInan& interest in the results of the research supporting this article has or will confer a benefit upon the authors or won am orzanization with which the authors are associated. ‘Rkpriit re’,,ests to Yu-Shih Yang, MD, PhD, Department of Obstetrics and Gynecology, National Taiwan University Hospital, No. 7, Chung-Shari South Road, Taipei, Taiwan. 0 1998 by the American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation 0003-9993/98/7902-4529$3.00/O
PY - 1998/1/1
Y1 - 1998/1/1
N2 - Anejaculation and poor semen quality are two major causes of infertility in men with spinal cord injury (SCI). The poor motility of retrieved sperm usually has low fertilization potential and is thought to be unfavorable for cryopreservation. This report describes a pregnancy after intracytoplasmic sperm injection (ICSI) with cryopreserved vasal-epididymal sperm from a man with SCI and anejaculation. An attempt was made to obtain sperm through electroejaculation, but no motile sperm were found in two trials. Therefore, the subject underwent vasal aspiration. The retrieved sperm had a concentration of 26 x 106/mL and a motility of 3%. ICSI was considered to be the best choice for the couple, but the wife did not become pregnant in the first cycle of treatment. A successful pregnancy was achieved by ICSI in the second cycle using frozen-thawed sperm, supernumerary in the previous cycle, with a density of 5 x 106/mL and 1% motility. A set of healthy twins, one boy and one girl, were delivered via cesarean section at 36 weeks of gestation. Complementary to other assisted reproductive techniques, ICSI may provide men with SCI a greater opportunity to father children. The supernumerary sperm, regardless of quality, should be cryopreserved to avoid the necessity and risk of repeated assisted ejaculations and aspirations of the genital tract.
AB - Anejaculation and poor semen quality are two major causes of infertility in men with spinal cord injury (SCI). The poor motility of retrieved sperm usually has low fertilization potential and is thought to be unfavorable for cryopreservation. This report describes a pregnancy after intracytoplasmic sperm injection (ICSI) with cryopreserved vasal-epididymal sperm from a man with SCI and anejaculation. An attempt was made to obtain sperm through electroejaculation, but no motile sperm were found in two trials. Therefore, the subject underwent vasal aspiration. The retrieved sperm had a concentration of 26 x 106/mL and a motility of 3%. ICSI was considered to be the best choice for the couple, but the wife did not become pregnant in the first cycle of treatment. A successful pregnancy was achieved by ICSI in the second cycle using frozen-thawed sperm, supernumerary in the previous cycle, with a density of 5 x 106/mL and 1% motility. A set of healthy twins, one boy and one girl, were delivered via cesarean section at 36 weeks of gestation. Complementary to other assisted reproductive techniques, ICSI may provide men with SCI a greater opportunity to father children. The supernumerary sperm, regardless of quality, should be cryopreserved to avoid the necessity and risk of repeated assisted ejaculations and aspirations of the genital tract.
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U2 - 10.1016/S0003-9993(98)90303-3
DO - 10.1016/S0003-9993(98)90303-3
M3 - Article
C2 - 9474007
AN - SCOPUS:0031951037
SN - 0003-9993
VL - 79
SP - 218
EP - 221
JO - Archives of Physical Medicine and Rehabilitation
JF - Archives of Physical Medicine and Rehabilitation
IS - 2
ER -