TY - JOUR
T1 - Predictors of time to relapse following ustekinumab withdrawal in patients with psoriasis who had responded to therapy
T2 - An eight-year multicenter study
AU - Chiu, Hsien-Yi
AU - Hui, Rosaline Chung-Yee
AU - Tsai, Tsen-Fang
AU - Chen, Yang-Ching
AU - Chang Liao, Nien-Feng
AU - Chen, Po-Hua
AU - Lai, Po-Ju
AU - Wang, Ting-Shun
AU - Huang, Yu-Huei
N1 - Copyright © 2019. Published by Elsevier Inc.
PY - 2019/1/28
Y1 - 2019/1/28
N2 - BACKGROUND: Data on predictors and time to relapse in psoriasis patients discontinuing therapy in a real world setting are scarce.OBJECTIVE: To investigate predictors of relapse after withdrawal of ustekinumab in psoriasis patients.METHOD: This study screened 500 psoriasis patients who received ustekinumab (669 treatment episodes (TEs)) between 2011 and 2018. Overall, 202 patients (304 TEs), who had responded to therapy and were withdrawn from ustekinumab treatment, were included.RESULTS: The cumulative probabilities of relapse-free at 6 months, 12 months, 18 months, 24 months and 36 months of withdrawal from ustekinumab treatment was 49.3%, 12.6%, 5.3%, 4.7% and 1.6%, respectively. Multivariate regression analyses with a generalized estimating equation showed that after adjustments, biologics-naive, the maximum Psoriasis Area and Severity Index (PASI) improvement on ustekinumab, time to achieve PASI-50 after initiation of ustekinumab, family history of psoriasis, chronic kidney disease, and immunosuppressants use while off ustekinumab were significant predictors of time to relapse following ustekinumab discontinuation.LIMITATION: Non-randomized allocation of duration of treatment and follow-up.CONCLUSION: Given high rates of relapse, withdrawal of ustekinumab from patients with well-controlled psoriasis cannot be recommended.
AB - BACKGROUND: Data on predictors and time to relapse in psoriasis patients discontinuing therapy in a real world setting are scarce.OBJECTIVE: To investigate predictors of relapse after withdrawal of ustekinumab in psoriasis patients.METHOD: This study screened 500 psoriasis patients who received ustekinumab (669 treatment episodes (TEs)) between 2011 and 2018. Overall, 202 patients (304 TEs), who had responded to therapy and were withdrawn from ustekinumab treatment, were included.RESULTS: The cumulative probabilities of relapse-free at 6 months, 12 months, 18 months, 24 months and 36 months of withdrawal from ustekinumab treatment was 49.3%, 12.6%, 5.3%, 4.7% and 1.6%, respectively. Multivariate regression analyses with a generalized estimating equation showed that after adjustments, biologics-naive, the maximum Psoriasis Area and Severity Index (PASI) improvement on ustekinumab, time to achieve PASI-50 after initiation of ustekinumab, family history of psoriasis, chronic kidney disease, and immunosuppressants use while off ustekinumab were significant predictors of time to relapse following ustekinumab discontinuation.LIMITATION: Non-randomized allocation of duration of treatment and follow-up.CONCLUSION: Given high rates of relapse, withdrawal of ustekinumab from patients with well-controlled psoriasis cannot be recommended.
U2 - 10.1016/j.jaad.2019.01.035
DO - 10.1016/j.jaad.2019.01.035
M3 - Article
C2 - 30703455
SN - 0190-9622
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
ER -