@article{ac26f0e4a82840549919539707768f9a,
title = "Predictors of clinical progression in HIV-1-infected adults initiating combination antiretroviral therapy with advanced disease in the Asia-Pacific region: Results from the TREAT Asia HIV Observational Database",
abstract = "The majority of HIV-infected patients in developing countries commences combination antiretroviral therapy (cART) with advanced disease. We examined predictors of disease progression in patients initiating cART with CD4 count ≤200 cells/mm3 in the TREAT Asia HIV Observational Database. The main outcome measure was progression to either an AIDS-defining illness or death occurring 6 months after initiation of cART. We used survival analysis methods. A total of 1255 patients contributed 2696 person years of follow-up; 73 were diagnosed with AIDS and 9 died. The rate of progression to the combined end point was 3.0 per 100 person years. The factors significantly associated with a higher risk of disease progression were Indian ethnicity, infection through intravenous drug use, lower CD4 count, and hemoglobin ≤130 g/dL at 6 months. In conclusion, measurements of CD4 count and hemoglobin at month 6 may be useful for early identification of disease progression in resource-limited settings.",
keywords = "antiretroviral therapy, disease progression, HIV, resource-limited settings",
author = "H. Byakwaga and K. Petoumenos and J. Ananworanich and F. Zhang and Boyd, {M. A.} and T. Sirisanthana and Li, {P. C.K.} and C. Lee and Mean, {C. V.} and V. Saphonn and Omar, {S. F.S.} and S. Pujari and P. Phanuphak and Lim, {P. L.} and N. Kumarasamy and Chen, {Y. M.A.} and Merati, {T. P.} and S. Sungkanuparph and R. Ditangco and S. Oka and G. Tau and J. Zhou and Law, {M. G.} and S. Emery",
note = "Funding Information: The TREAT Asia HIV Observational Database is part of the Asia-Pacific HIV Observational Database and is an initiative of TREAT Asia, a program of amfAR, The Foundation for AIDS Research, with support from the National Institute of Allergy and Infectious Diseases (NIAID) of the US National Institutes of Health (NIH) as part of the International Epidemiologic Databases to Evaluate AIDS (IeDEA; grant No. U01AI069907), and from the Dutch Ministry of Foreign Affairs through a partnership with Stichting Aids Fonds. The National Centre in HIV Epidemiology and Clinical Research is funded by the Australian Government Department of Health and Ageing, and is affiliated with the Faculty of Medicine, The University of New South Wales. The content of this publication is solely the responsibility of the authors and does not necessarily represent the official views of any of the institutions mentioned above. ",
year = "2013",
month = jul,
day = "1",
doi = "10.1177/1545109712469684",
language = "English",
volume = "12",
pages = "270--277",
journal = "Journal of the International Association of Providers of AIDS Care",
issn = "2325-9574",
publisher = "SAGE Publications Inc.",
number = "4",
}
