TY - JOUR
T1 - Predictors of abnormality in thallium myocardial perfusion scans for type 2 diabetes
AU - Lu, Chieh Hua
AU - Pei, Dee
AU - Wu, Chung Ze
AU - Kua, Hui Chun
AU - Liang, Yao Jen
AU - Chen, Yen Lin
AU - Lin, Jiunn Diann
N1 - Funding Information:
The work was supported by a Grant from Cardinal Tien Hospital (CTH106A-2B10). Acknowledgements
Funding Information:
The authors thank all participants in this study. This manuscript was edited by Wallace Academic Editing.
Publisher Copyright:
© 2020, Springer Japan KK, part of Springer Nature.
PY - 2021/2
Y1 - 2021/2
N2 - Type 2 diabetes mellitus (T2DM) increases coronary artery disease (CAD) risk. In this study, we used T2DM clinical variables to predict abnormality in thallium-201 myocardial perfusion scans (Th-201 scans). These clinical variables were summed stress score (SSS), summed rest score, and summed difference score (SDS), with data obtained from 368 male and 428 female participants with T2DM. Multiple linear regression results were as follows. In male participants, body mass index (BMI) and creatinine (Cr) were associated with SSS (β = 0.224, p < 0.001; β = 0.140, p = 0.022, respectively), and only BMI was associated with SDS (β = 0.174, p = 0.004). In female participants, BMI and high-density lipoprotein cholesterol level were associated with SSS (β = 0.240, p < 0.001; β = − 0.120, p = 0.048, respectively), and only BMI was correlated with SDS (β = 0.123, p = 0.031). Our multivariate logistic regression indicated that in male and female participants, BMI was the only independent indicator of high SSS (SSS ≥ 9). In this study, we demonstrated that male patients have a higher SSS and SDS than female patients do in Th-201 scans for T2DM in a Chinese population. For male and female patients, BMI was the strongest predictor of abnormality in Th-201 scans. Our results can help clinicians identify patients with T2DM at high risk of CAD.
AB - Type 2 diabetes mellitus (T2DM) increases coronary artery disease (CAD) risk. In this study, we used T2DM clinical variables to predict abnormality in thallium-201 myocardial perfusion scans (Th-201 scans). These clinical variables were summed stress score (SSS), summed rest score, and summed difference score (SDS), with data obtained from 368 male and 428 female participants with T2DM. Multiple linear regression results were as follows. In male participants, body mass index (BMI) and creatinine (Cr) were associated with SSS (β = 0.224, p < 0.001; β = 0.140, p = 0.022, respectively), and only BMI was associated with SDS (β = 0.174, p = 0.004). In female participants, BMI and high-density lipoprotein cholesterol level were associated with SSS (β = 0.240, p < 0.001; β = − 0.120, p = 0.048, respectively), and only BMI was correlated with SDS (β = 0.123, p = 0.031). Our multivariate logistic regression indicated that in male and female participants, BMI was the only independent indicator of high SSS (SSS ≥ 9). In this study, we demonstrated that male patients have a higher SSS and SDS than female patients do in Th-201 scans for T2DM in a Chinese population. For male and female patients, BMI was the strongest predictor of abnormality in Th-201 scans. Our results can help clinicians identify patients with T2DM at high risk of CAD.
KW - Coronary artery disease
KW - Summed difference score
KW - Summed stress score
KW - Thallium 201 scan
KW - Type 2 diabetes mellitus
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U2 - 10.1007/s00380-020-01681-2
DO - 10.1007/s00380-020-01681-2
M3 - Article
C2 - 32816060
AN - SCOPUS:85089678615
SN - 0910-8327
VL - 36
SP - 180
EP - 188
JO - Heart and Vessels
JF - Heart and Vessels
IS - 2
ER -
