TY - JOUR
T1 - Power spectral analysis of the electroencephalographic and hemodynamic correlates of propofol anesthesia in the rat
T2 - Intravenous bolus administration
AU - Shyr, Ming Hwang
AU - Yang, Chen Hsien
AU - Kuo, Terry B.J.
AU - Pan, Wynn H.T.
AU - Tan, Peter P.C.
AU - Chan, Samuel H.H.
N1 - Funding Information:
Supported in part by research grant NSC-82-0412-B010-010 to S.H.H.C. from the National Science Council, Taiwan, Republic of China. The generous supply of propofol by ICI Pharma Taiwan is greatly appreciated.
PY - 1993/4/30
Y1 - 1993/4/30
N2 - Based on the tail-flick response to noxious thermal stimuli, we determined in the present study that the minimal effective antinociceptive dose of propofol in adult, male Sprague-Dawley rats, given in an intravenous bolus manner, was 10 mg/kg. Simultaneous power spectral analysis of the electroencephalographic (EEG) and systemic arterial pressure signals further revealed a concomitant transient suppression of the EEG activity, primarily in the θ{symbol} and σ bands, alongside minor hypotensive and negative inotropic and chronotropic actions, but with maintained vasomotor tone. These alterations followed a time course that paralleled the plasma concentration of propofol in the arterial blood, as detected by high-performance liquid chromatography.
AB - Based on the tail-flick response to noxious thermal stimuli, we determined in the present study that the minimal effective antinociceptive dose of propofol in adult, male Sprague-Dawley rats, given in an intravenous bolus manner, was 10 mg/kg. Simultaneous power spectral analysis of the electroencephalographic (EEG) and systemic arterial pressure signals further revealed a concomitant transient suppression of the EEG activity, primarily in the θ{symbol} and σ bands, alongside minor hypotensive and negative inotropic and chronotropic actions, but with maintained vasomotor tone. These alterations followed a time course that paralleled the plasma concentration of propofol in the arterial blood, as detected by high-performance liquid chromatography.
KW - Anesthesia
KW - Electroencephalogram
KW - Noxious thermal stimulation
KW - Power spectral analysis
KW - Propofol
KW - Rat
KW - Systemic arterial pressure
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U2 - 10.1016/0304-3940(93)90312-9
DO - 10.1016/0304-3940(93)90312-9
M3 - Article
C2 - 8327191
AN - SCOPUS:0027230989
SN - 0304-3940
VL - 153
SP - 161
EP - 164
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -