TY - JOUR
T1 - Power spectral analysis of the electroencephalographic and hemodynamic correlates of propofol anesthesia in the rat
T2 - Intravenous infusion
AU - Tan, Peter P.C.
AU - Shyr, Ming Hwang
AU - Yang, Chen Hsein
AU - Kuo, Terry B.J.
AU - Pan, Wynn H.T.
AU - Chan, Samuel H.H.
N1 - Funding Information:
Supported in part by research Grant NSC-82-0412-B010-010 to S.H.H.C. from the National Science Council, Taiwan, Republic of China. The generous supply of propofol by ICI Pharma Taiwan is greatly appreciated.
PY - 1993/10/1
Y1 - 1993/10/1
N2 - Based on the tail-flick response to noxious thermal stimuli, we determined in the present study that effective antinociception could be achieved in adult male Sprague-Dawley rats 15 min after intravenous infusion of propofol at 60 mg/kg/h. Simultaneous power spectral analysis of the electroencephalographic (EEG) and systemic arterial pressure signals further revealed a concomitant depression of the activity of all EEG frequency bands (δ, θ, α, β), alongside hypotension, negative inotropic and chronotropic actions, and attenuated baroreceptor reflex and vasomotor activity. These effects were congruent with a plasma concentration of propofol in the arterial blood of 1.70 ± 0.13 μg/ml, as determined by high-performance liquid chromatography.
AB - Based on the tail-flick response to noxious thermal stimuli, we determined in the present study that effective antinociception could be achieved in adult male Sprague-Dawley rats 15 min after intravenous infusion of propofol at 60 mg/kg/h. Simultaneous power spectral analysis of the electroencephalographic (EEG) and systemic arterial pressure signals further revealed a concomitant depression of the activity of all EEG frequency bands (δ, θ, α, β), alongside hypotension, negative inotropic and chronotropic actions, and attenuated baroreceptor reflex and vasomotor activity. These effects were congruent with a plasma concentration of propofol in the arterial blood of 1.70 ± 0.13 μg/ml, as determined by high-performance liquid chromatography.
KW - Anesthesia
KW - Electroencephalogram
KW - Intravenous infusion
KW - Noxious thermal stimulation
KW - Power spectral analysis
KW - Propofol
KW - Rat
KW - Systemic arterial pressure
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U2 - 10.1016/0304-3940(93)90414-G
DO - 10.1016/0304-3940(93)90414-G
M3 - Article
C2 - 8247355
AN - SCOPUS:0027515197
SN - 0304-3940
VL - 160
SP - 205
EP - 208
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -