Background/Purpose: The aim of the present study was to review the clinical manifestations, risk factors and outcome in traumatic brain injury (TBI) patients with post-traumatic cerebrospinal fluid (CSF) leakage. Methods: We reviewed the medical records of 1,323 patients who were identified with CSF leakage that occurred after head trauma. Results: Patients complicated with CSF leakage manifested a more rigorous clinical course and poorer outcome compared to patients with other TBI features: in mild head injury, patients with brain injury complicated with CSF leakage alone had a 24.5% risk ratio for developing intracranial hemorrhage, and the presence of post-traumatic CSF leakage with or without skull fracture resulted in a higher percentage of fatality. Conclusion: Post-traumatic CSF leakage amongst head injury patients has serious complications in nonfatal TBI cases, and indicates a risk of developing post-traumatic intracranial hemorrhage as the patients' final outcome.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalJournal of Experimental and Clinical Medicine(Taiwan)
Issue number1
Publication statusPublished - Feb 2010


  • cerebrospinal fluid leakage
  • intracranial hemorrhage
  • post-traumatic amnesia
  • skull fracture
  • traumatic brain injury

ASJC Scopus subject areas

  • Medicine(all)


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