TY - JOUR
T1 - Possible involvement of nitric oxide and peroxynitrite in nasal polyposis
AU - Kang, Bor Hwang
AU - Huang, Nan Chieh
AU - Wang, Hsing Won
PY - 2004
Y1 - 2004
N2 - Background: Nitric oxide (NO) is implicated in inflammation. Its role in the pathogenesis of nasal polyposis is not clear. Methods: The expression of inducible NO synthase (iNOS), and the production of peroxynitrite represented by the formation of 3-nitrotyrosine (3-NT) were examined by immunohistochemistry in nasal polyps. The contents of superoxide dismutases (SODs) in nasal polyps and nasal mucosa were assessed by Western blot analyses. Results: iNOS expression and 3-NT accumulation were noted in mucosal epithelium, vascular endothelium, and interstitial cells of nasal polyps. In comparison with our previous study on the nasal mucosa from patients with rhinitis, the stromal cells of the nasal polyp had higher labeling intensity for both iNOS and 3-NT. The polyp showed similar levels of CuZnSOD and MnSOD as those of nasal mucosa. Conclusions. The iNOS/NO system may be important in the pathophysiology of nasal polyposis. The increased peroxynitrite may result from increased iNOS expression but is not related to decreased SODs.
AB - Background: Nitric oxide (NO) is implicated in inflammation. Its role in the pathogenesis of nasal polyposis is not clear. Methods: The expression of inducible NO synthase (iNOS), and the production of peroxynitrite represented by the formation of 3-nitrotyrosine (3-NT) were examined by immunohistochemistry in nasal polyps. The contents of superoxide dismutases (SODs) in nasal polyps and nasal mucosa were assessed by Western blot analyses. Results: iNOS expression and 3-NT accumulation were noted in mucosal epithelium, vascular endothelium, and interstitial cells of nasal polyps. In comparison with our previous study on the nasal mucosa from patients with rhinitis, the stromal cells of the nasal polyp had higher labeling intensity for both iNOS and 3-NT. The polyp showed similar levels of CuZnSOD and MnSOD as those of nasal mucosa. Conclusions. The iNOS/NO system may be important in the pathophysiology of nasal polyposis. The increased peroxynitrite may result from increased iNOS expression but is not related to decreased SODs.
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U2 - 10.1177/194589240401800401
DO - 10.1177/194589240401800401
M3 - Article
C2 - 15490564
AN - SCOPUS:4644355916
SN - 1050-6586
VL - 18
SP - 191
EP - 196
JO - American Journal of Rhinology
JF - American Journal of Rhinology
IS - 4
ER -