TY - JOUR
T1 - Positron Emission Tomography-Computed Tomography in Predicting Locoregional Invasion in Esophageal Squamous Cell Carcinoma
AU - Hsu, Wen Hu
AU - Hsu, Po Kuei
AU - Wang, Shyh Jen
AU - Lin, Ko Han
AU - Huang, Chien Sheng
AU - Hsieh, Chih Cheng
AU - Wu, Yu Chung
PY - 2009/5
Y1 - 2009/5
N2 - Background: In order to clarify the role of positron emission tomography-computed tomography (PET/CT) in thoracic esophageal squamous cell carcinoma we investigated its value in predicting locoregional invasion. Methods: Forty-five patients receiving curative esophagectomy and lymph node dissection were included. The relationship between PET/CT findings and pathology results were studied. Correlation between nodal uptake and the modified lymph node staging, which is based on number of involved nodes (N0 = no nodes; N1 = 1 to 3 nodes; N2 = more than 3 nodes), was evaluated. Results: The mean maximal standardized uptake value (SUVmax) was 5.09 ± 4.00 in T1, 14.17 ± 2.46 in T2, 13.32 ± 3.96 in T3, and 10.37 ± 1.94 in T4 primary tumor. The SUVmax was significantly lower in stage T1 tumors than in stage T2 and T3 tumors. For regional nodal involvement, PET/CT findings significantly correlated with pathology results. However, the sensitivity, specificity, and accuracy of PET/CT were only 57.1%, 83.3%, and 71.1%, respectively, and even lower for detecting nonregional lymph node metastasis. When stratified by the modified staging system, the mean SUVmax was 0.64 ± 1.60 in N0, 1.43 ± 2.08 in N1, and 4.67 ± 4.32 in N2 regional lymph node metastases, and was significantly higher in patients with N2 metastasis than in patients with N0 and N1 metastases. Conclusions: Locoregional invasion in esophageal cancer can be predicted by PET/CT. The SUVmax of the primary tumor helped identify T1 tumor, and the SUVmax of the regional lymph nodes correlated with the severity of nodal involvement.
AB - Background: In order to clarify the role of positron emission tomography-computed tomography (PET/CT) in thoracic esophageal squamous cell carcinoma we investigated its value in predicting locoregional invasion. Methods: Forty-five patients receiving curative esophagectomy and lymph node dissection were included. The relationship between PET/CT findings and pathology results were studied. Correlation between nodal uptake and the modified lymph node staging, which is based on number of involved nodes (N0 = no nodes; N1 = 1 to 3 nodes; N2 = more than 3 nodes), was evaluated. Results: The mean maximal standardized uptake value (SUVmax) was 5.09 ± 4.00 in T1, 14.17 ± 2.46 in T2, 13.32 ± 3.96 in T3, and 10.37 ± 1.94 in T4 primary tumor. The SUVmax was significantly lower in stage T1 tumors than in stage T2 and T3 tumors. For regional nodal involvement, PET/CT findings significantly correlated with pathology results. However, the sensitivity, specificity, and accuracy of PET/CT were only 57.1%, 83.3%, and 71.1%, respectively, and even lower for detecting nonregional lymph node metastasis. When stratified by the modified staging system, the mean SUVmax was 0.64 ± 1.60 in N0, 1.43 ± 2.08 in N1, and 4.67 ± 4.32 in N2 regional lymph node metastases, and was significantly higher in patients with N2 metastasis than in patients with N0 and N1 metastases. Conclusions: Locoregional invasion in esophageal cancer can be predicted by PET/CT. The SUVmax of the primary tumor helped identify T1 tumor, and the SUVmax of the regional lymph nodes correlated with the severity of nodal involvement.
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U2 - 10.1016/j.athoracsur.2009.02.065
DO - 10.1016/j.athoracsur.2009.02.065
M3 - Article
C2 - 19379906
AN - SCOPUS:64649107040
SN - 0003-4975
VL - 87
SP - 1564
EP - 1568
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 5
ER -
