利用吐氣末正壓面罩裝置協助改善慢性氣喘病患在休息及運動時之肺功能

The most common obstructive diseases are moderate to severe asthma and chronic obstructive pulmonary disease, which consist of varying combinations of air trapping and emphysema. Twenty chronic asthmatic patients (aged 61.5 ± 1.8 years) (4 female, 16 male) with moderate to sever airway obstruction were enrolled in the study. Patients wore a PEPM with 6 cmH2O for 20 minutes at rest to improve airway flow rate, and then performed the same walking test. Maximal expiratory and inspiratory flow volume loop were obtained before and after using the PEPM at rest and after exercise. We use the pair t-test for analysis the result. At rest, significantly increased forced vital capacity and forced expiratory volume in one second (p＜0.01), as well as peak ispiratory flow (p＜0.001). The flow-volume loop was shifted to the right after wearing a PEPM, suggesting that PEPM significantly increased volume below TLC to end inspiratory (EIV), volume below TLC to end expiratory (EEV)and displacement (p＜0.0001, respectively). Wearing PEP during walking test significantly increased flow-volume loop EIV, EEV and displacement. This new device of PEPM can prevent dynamic air-trapping response on exercise in patients with chronic asthma.