Porcine lactoferrin as feedstuff additive elevates avian immunity and potentiates vaccination

Che Ming Hung, Shinn Chih Wu, Chih Ching Yen, Ming Fong Lin, Yi Wen Lai, Yu Tang Tung, Hsiao Ling Chen, Chuan Mu Chen

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


In this study, recombinant porcine lactoferrin (PLF) was used as feedstuff additive to investigate the effects of peripheral lymphocyte proliferation and serum antibody titers in chickens vaccinated against the infectious bursal disease (IBD) virus. Treatment groups were fed three doses of PLF powder in their diet (0.5, 1.0, and 2.0% w/w), and the IBD vaccine was administrated at 1 and 3 weeks of age. At 8, 12, and 16 weeks after vaccination, serum IBD antibody titers were measured via the micro-method and T cell proliferation rates were evaluated. The results revealed that a high dose of PLF led to significant increases in serum IgA, IgG and IBD-specific antibody titers (P < 0.05). PLF administration, at either low or high doses, enhanced the expression of IFN-γ and IL-12 in chicken T lymphocytes. These results suggest that PLF enhances cell-mediated immunity and augment the ability of IBD vaccination to strengthen subsequent anti-viral responses.

Original languageEnglish
Pages (from-to)579-587
Number of pages9
Issue number3
Publication statusPublished - Jun 2010
Externally publishedYes


  • Cytokine
  • Infectious bursal disease (IBD)
  • Lymphocyte proliferation
  • Porcine lactoferrin
  • Serum antibody titer
  • Vaccination

ASJC Scopus subject areas

  • Biomaterials
  • General Biochemistry,Genetics and Molecular Biology
  • General Agricultural and Biological Sciences
  • Metals and Alloys


Dive into the research topics of 'Porcine lactoferrin as feedstuff additive elevates avian immunity and potentiates vaccination'. Together they form a unique fingerprint.

Cite this