Objectives: Fungus Cordyceps militaris has been used as a herbal tonic in traditional Chinese medicine, which could be surface liquid-cultured for mycelia production. To evaluate the potential of polysaccharides obtained from mycelia of Cordyceps militaris (PS-MCM) for attenuation of side-effects of chemotherapy. Methods: Doxorubicin was used to induce cytotoxicity in THP-1 monocytes and EL-4 T cells, and the effects of PS-MCM on cell viability and cytokine production were detected on doxorubicin-treated THP-1 and EL-4 cells. Results: PS-MCM reduced doxorubicin-induced cell death and promoted cell proliferation in THP-1 and EL-4 cells. Moreover, PS-MCM elevated the level of cytokines associated with immune-modulation of THP-1 and EL-4 cells. Conclusion: These findings indicate that PS-MCM has potential for development as a functional food to counteract side effects of chemotherapy.

Original languageEnglish
Pages (from-to)2156-2163
Number of pages8
JournalAfrican Health Sciences
Issue number2
Publication statusPublished - Jun 2019


  • Chemotherapy
  • Cordyceps militaris
  • Doxorubicin
  • Immunotherapy
  • Traditional Chinese medicine

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Polysaccharides obtained from mycelia of cordyceps militaris attenuated doxorubicin-induced cytotoxic effects in chemotherapy'. Together they form a unique fingerprint.

Cite this