Polyketides from the littoral plant associated fungus Pseudallescheria boydii

Ya Chih Chang; Tzu Shing Deng; Ka Lai Pang; Che Jen Hsiao; Yi Ying Chen; Shye Jye Tang; Zong-Huei Li

doi:10.1021/np400192q

Polyketides from the littoral plant associated fungus Pseudallescheria boydii

Ya Chih Chang, Tzu Shing Deng, Ka Lai Pang, Che Jen Hsiao, Yi Ying Chen, Shye Jye Tang, Zong-Huei Li

Graduate Institute of Pharmacognosy

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Four previously unreported chemical entities, boydone A (1), boydone B (2), botryorhodine F (3), and botryorhodine G (4), along with five known compounds, fusidilactone A (5), (R)-(-)-mevalonolactone (6), (R)-(-)-lactic acid (7), ovalicin (8), and botryorhodine C (9), were isolated from the ethyl acetate extracts of the fermented broths of the fungal strain Pseudallescheria boydii NTOU2362. The structures of 1-9 were characterized on the basis of their spectroscopic data analyses. The absolute configurations of 1 and 2 were established by comparison with the literature and the modified Mosher's method. The growth inhibitory activities of 1-9 against the A549 non-small-cell lung cancer cell line were evaluated, and 2 and 8 exhibited moderate to potent bioactivities with GI₅₀ values of 41.3 and 4.1 μM, respectively, in comparison with fluorouracil (GI₅₀ = 3.6 μM).

Original language	English
Pages (from-to)	1796-1800
Number of pages	5
Journal	Journal of Natural Products
Volume	76
Issue number	9
DOIs	https://doi.org/10.1021/np400192q
Publication status	Published - Sept 27 2013

ASJC Scopus subject areas

Complementary and alternative medicine
Molecular Medicine
Organic Chemistry
Analytical Chemistry
Pharmaceutical Science
Pharmacology
Drug Discovery

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/np400192q

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title = "Polyketides from the littoral plant associated fungus Pseudallescheria boydii",

abstract = "Four previously unreported chemical entities, boydone A (1), boydone B (2), botryorhodine F (3), and botryorhodine G (4), along with five known compounds, fusidilactone A (5), (R)-(-)-mevalonolactone (6), (R)-(-)-lactic acid (7), ovalicin (8), and botryorhodine C (9), were isolated from the ethyl acetate extracts of the fermented broths of the fungal strain Pseudallescheria boydii NTOU2362. The structures of 1-9 were characterized on the basis of their spectroscopic data analyses. The absolute configurations of 1 and 2 were established by comparison with the literature and the modified Mosher's method. The growth inhibitory activities of 1-9 against the A549 non-small-cell lung cancer cell line were evaluated, and 2 and 8 exhibited moderate to potent bioactivities with GI50 values of 41.3 and 4.1 μM, respectively, in comparison with fluorouracil (GI50 = 3.6 μM).",

author = "Chang, {Ya Chih} and Deng, {Tzu Shing} and Pang, {Ka Lai} and Hsiao, {Che Jen} and Chen, {Yi Ying} and Tang, {Shye Jye} and Zong-Huei Li",

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doi = "10.1021/np400192q",

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AU - Chang, Ya Chih

AU - Deng, Tzu Shing

AU - Pang, Ka Lai

AU - Hsiao, Che Jen

AU - Chen, Yi Ying

AU - Tang, Shye Jye

AU - Li, Zong-Huei

PY - 2013/9/27

Y1 - 2013/9/27

N2 - Four previously unreported chemical entities, boydone A (1), boydone B (2), botryorhodine F (3), and botryorhodine G (4), along with five known compounds, fusidilactone A (5), (R)-(-)-mevalonolactone (6), (R)-(-)-lactic acid (7), ovalicin (8), and botryorhodine C (9), were isolated from the ethyl acetate extracts of the fermented broths of the fungal strain Pseudallescheria boydii NTOU2362. The structures of 1-9 were characterized on the basis of their spectroscopic data analyses. The absolute configurations of 1 and 2 were established by comparison with the literature and the modified Mosher's method. The growth inhibitory activities of 1-9 against the A549 non-small-cell lung cancer cell line were evaluated, and 2 and 8 exhibited moderate to potent bioactivities with GI50 values of 41.3 and 4.1 μM, respectively, in comparison with fluorouracil (GI50 = 3.6 μM).

AB - Four previously unreported chemical entities, boydone A (1), boydone B (2), botryorhodine F (3), and botryorhodine G (4), along with five known compounds, fusidilactone A (5), (R)-(-)-mevalonolactone (6), (R)-(-)-lactic acid (7), ovalicin (8), and botryorhodine C (9), were isolated from the ethyl acetate extracts of the fermented broths of the fungal strain Pseudallescheria boydii NTOU2362. The structures of 1-9 were characterized on the basis of their spectroscopic data analyses. The absolute configurations of 1 and 2 were established by comparison with the literature and the modified Mosher's method. The growth inhibitory activities of 1-9 against the A549 non-small-cell lung cancer cell line were evaluated, and 2 and 8 exhibited moderate to potent bioactivities with GI50 values of 41.3 and 4.1 μM, respectively, in comparison with fluorouracil (GI50 = 3.6 μM).

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Polyketides from the littoral plant associated fungus Pseudallescheria boydii

Abstract

ASJC Scopus subject areas

UN SDGs

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